Protein Alignment CG34376 and BTBD18

DIOPT Version :10

• Sequence 1: NP_732741.1
• Gene: CG34376 / 42638
• FlyBaseID: FBgn0085405
• Length: 681
• Species: Drosophila melanogaster
• Sequence 2: NP_001138573.1
• Gene: BTBD18 / 643376
• HGNCID: 37214
• Length: 712
• Species: Homo sapiens
• Alignment Length: 739
• Identity: 137/739 - (18%)
• Similarity: 227/739 - (30%)
• Gaps: 230/739 - (31%)

  Fly    31 DVTLACDGKLLHAHKIVLAICSPYFQE-IFTTNPCKHPIIILK--DVSFNIMMELLEFMYQGVVN 92
            ||.|..:|:.:.||..:|:.|||:|.| :....|.:...::|:  .:..:.:.:|::|:|...:.
Human    35 DVLLQAEGEAVPAHCCILSACSPFFTERLERERPAQGGKVVLELGGLKISTLRKLVDFLYTSEME 99

  Fly    93 VKHTELQSF------MKIGQL--LQIKG------------------------------------- 112
            |...|.|..      :::.:|  ||::|
Human   100 VSQEEAQDVLSAARQLRVSELESLQLEGGKLVKAPQGRRLNRECLQPTSAAPISARVVTPSHHPH 164

  Fly   113 --LATNSNSSPGSSVSEKSSSQPPAEESSNTNSTNHHNSS-----------TNSNNNSKSETDHN 164
              |.||....|..::..||..:....:.:|..:.::.:.:           |....||...:...
Human   165 TPLPTNQTPCPLGAIRLKSLGKEEGPQENNRQNADNLSGTLLLKRKARACPTPQEKNSSPSSHSQ 229

  Fly   165 ESKGQSNSRTTSPGGASRASNDAS---HLY-----TSNKRPMPSD---------FGSDSLSIYSG 212
            |.:...|.....|...|..|...|   ||.     .|..:|.|..         .||.|:....|
Human   230 EPRENKNDTALDPTVLSPPSLYPSVDKHLLPRKIRLSRSKPSPGICTSKPSSILSGSSSVPATPG 294

  Fly   213 KQLRRSLKDHGSGGSEGGGGDHADTAAGLDNSMNSEEFFLPPIP------QITMGEQRYDLGGLK 271
            ::|.|                        ..|:|.|.....|.|      |.|.........|..
Human   295 RRLWR------------------------QRSVNKETPEDKPKPGRASPLQSTPNPSGLGKTGGS 335

  Fly   272 RESDGHHHGPLSAGGGNSGSVGSLTS---------SASPSAPIRN-PFAPNFMDSFNYYKGGNSS 326
            |:.......| ::.....|.||.:..         ......|::| ..:|...|     .||:..
Human   336 RKRSPEVRAP-NSDSAEEGQVGRVKLRKIVNGTCWEVVQETPLKNTQDSPQIPD-----PGGDFQ 394

  Fly   327 GPSGSSNNSVGPGGVNNNGSVG-------------------LGSGAEYPNELYMPNDYSKSFANH 372
            .|||:...|      :|...:.                   |.|.:..|:...:.:::..|
Human   395 EPSGTQPFS------SNEQEMSPTRTELCQDSPMCTKLQDILVSASHSPDHPVVKSEFESS---- 449

  Fly   373 MDIPSSGSNMVMLS---------TTSLLHGNCVFNRNNTVATQQGMKTYWLCKSYRISMCRARCI 428
               |.......||:         .|:||...|.                  .:.|||:  .|...
Human   450 ---PELVEKEPMLAIDCREPYAFDTALLEQPCE------------------AEEYRIT--SAAAT 491

  Fly   429 THLGRIISATGVHNHTPHMRGGQGSSAP----STASVSGNPAPTPISSQAGYSLTDGGGHLGPDL 489
            :.|..|:.         .|..|.....|    .:....|...||...::.|.:..:|.....||:
Human   492 SELEEILD---------FMLCGSDIEPPIGSLESPGAEGCRTPTYHLTETGKNWIEGEEWCLPDM 547

  Fly   490 QHGNR-VTNMFANQTPPPPPPPPPLPVASTPHHPHHHHHL----GQPLPNLLVQHHPAPSHMEQH 549
            :...| :|.:   :..|......|..:.|....|.....:    |:..|:|.:     .|.....
Human   548 ELWPRELTEL---EKEPAGENRGPTELLSPLVMPSEVSEVLSVGGRWTPDLEI-----TSSQPLD 604

  Fly   550 GSSASLLHNPNLMHLQTPTHHHQQQHHQQHSPHNPPPPQQHNLELGGGSGSGAVLLSPAHLQQSP 614
            |....|||   :..|.||          |.|..:..||..:.:|    :|....|.:...|..||
Human   605 GQEDKLLH---VSSLDTP----------QRSYGDLSPPCSNWVE----TGLEVSLTTDELLYPSP 652

  Fly   615 QSNR--SSHSLQAQSPPPQSVEEQ 636
            ::.:  |.||....|.|..|.||:
Human   653 KAGKEVSGHSELLGSLPASSEEEE 676

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34376	NP_732741.1	BTB_POZ_BAB-like	29..112	CDD:349624	23/91 (25%)
		FLYWCH	387..443	CDD:461332	10/55 (18%)
BTBD18	NP_001138573.1	BTB_POZ_BTBD18	19..138	CDD:349602	24/102 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	157..176		3/18 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	212..355		31/167 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	374..410		11/46 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	653..676		7/22 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	691..712