DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34376 and BTBD18

DIOPT Version :9

Sequence 1:	NP_732741.1	Gene:	CG34376 / 42638	FlyBaseID:	FBgn0085405	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001138573.1	Gene:	BTBD18 / 643376	HGNCID:	37214	Length:	712	Species:	Homo sapiens

Alignment Length:	739	Identity:	137/739 - (18%)
Similarity:	227/739 - (30%)	Gaps:	230/739 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DVTLACDGKLLHAHKIVLAICSPYFQE-IFTTNPCKHPIIILK--DVSFNIMMELLEFMYQGVVN 92
            ||.|..:|:.:.||..:|:.|||:|.| :....|.:...::|:  .:..:.:.:|::|:|...:.
Human    35 DVLLQAEGEAVPAHCCILSACSPFFTERLERERPAQGGKVVLELGGLKISTLRKLVDFLYTSEME 99

  Fly    93 VKHTELQSF------MKIGQL--LQIKG------------------------------------- 112
            |...|.|..      :::.:|  ||::|
Human   100 VSQEEAQDVLSAARQLRVSELESLQLEGGKLVKAPQGRRLNRECLQPTSAAPISARVVTPSHHPH 164

  Fly   113 --LATNSNSSPGSSVSEKSSSQPPAEESSNTNSTNHHNSS-----------TNSNNNSKSETDHN 164
              |.||....|..::..||..:....:.:|..:.::.:.:           |....||...:...
Human   165 TPLPTNQTPCPLGAIRLKSLGKEEGPQENNRQNADNLSGTLLLKRKARACPTPQEKNSSPSSHSQ 229

  Fly   165 ESKGQSNSRTTSPGGASRASNDAS---HLY-----TSNKRPMPSD---------FGSDSLSIYSG 212
            |.:...|.....|...|..|...|   ||.     .|..:|.|..         .||.|:....|
Human   230 EPRENKNDTALDPTVLSPPSLYPSVDKHLLPRKIRLSRSKPSPGICTSKPSSILSGSSSVPATPG 294

  Fly   213 KQLRRSLKDHGSGGSEGGGGDHADTAAGLDNSMNSEEFFLPPIP------QITMGEQRYDLGGLK 271
            ::|.|                        ..|:|.|.....|.|      |.|.........|..
Human   295 RRLWR------------------------QRSVNKETPEDKPKPGRASPLQSTPNPSGLGKTGGS 335

  Fly   272 RESDGHHHGPLSAGGGNSGSVGSLTS---------SASPSAPIRN-PFAPNFMDSFNYYKGGNSS 326
            |:.......| ::.....|.||.:..         ......|::| ..:|...|     .||:..
Human   336 RKRSPEVRAP-NSDSAEEGQVGRVKLRKIVNGTCWEVVQETPLKNTQDSPQIPD-----PGGDFQ 394

  Fly   327 GPSGSSNNSVGPGGVNNNGSVG-------------------LGSGAEYPNELYMPNDYSKSFANH 372
            .|||:...|      :|...:.                   |.|.:..|:...:.:::..|
Human   395 EPSGTQPFS------SNEQEMSPTRTELCQDSPMCTKLQDILVSASHSPDHPVVKSEFESS---- 449

  Fly   373 MDIPSSGSNMVMLS---------TTSLLHGNCVFNRNNTVATQQGMKTYWLCKSYRISMCRARCI 428
               |.......||:         .|:||...|.                  .:.|||:  .|...
Human   450 ---PELVEKEPMLAIDCREPYAFDTALLEQPCE------------------AEEYRIT--SAAAT 491

  Fly   429 THLGRIISATGVHNHTPHMRGGQGSSAP----STASVSGNPAPTPISSQAGYSLTDGGGHLGPDL 489
            :.|..|:.         .|..|.....|    .:....|...||...::.|.:..:|.....||:
Human   492 SELEEILD---------FMLCGSDIEPPIGSLESPGAEGCRTPTYHLTETGKNWIEGEEWCLPDM 547

  Fly   490 QHGNR-VTNMFANQTPPPPPPPPPLPVASTPHHPHHHHHL----GQPLPNLLVQHHPAPSHMEQH 549
            :...| :|.:   :..|......|..:.|....|.....:    |:..|:|.:     .|.....
Human   548 ELWPRELTEL---EKEPAGENRGPTELLSPLVMPSEVSEVLSVGGRWTPDLEI-----TSSQPLD 604

  Fly   550 GSSASLLHNPNLMHLQTPTHHHQQQHHQQHSPHNPPPPQQHNLELGGGSGSGAVLLSPAHLQQSP 614
            |....|||   :..|.||          |.|..:..||..:.:|    :|....|.:...|..||
Human   605 GQEDKLLH---VSSLDTP----------QRSYGDLSPPCSNWVE----TGLEVSLTTDELLYPSP 652

  Fly   615 QSNR--SSHSLQAQSPPPQSVEEQ 636
            ::.:  |.||....|.|..|.||:
Human   653 KAGKEVSGHSELLGSLPASSEEEE 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34376	NP_732741.1	BTB	20..113	CDD:279045	24/131 (18%)
		BTB	31..115	CDD:197585	25/133 (19%)
		FLYWCH	390..443	CDD:282369	9/52 (17%)
BTBD18	NP_001138573.1	BTB	24..120	CDD:306997	20/84 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..176		3/18 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..355		31/167 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	374..410		11/46 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	653..676		7/22 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	691..712
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910