DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34376 and ttk

DIOPT Version :9

Sequence 1:	NP_732741.1	Gene:	CG34376 / 42638	FlyBaseID:	FBgn0085405	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001189329.1	Gene:	ttk / 48317	FlyBaseID:	FBgn0003870	Length:	813	Species:	Drosophila melanogaster

Alignment Length:	776	Identity:	175/776 - (22%)
Similarity:	267/776 - (34%)	Gaps:	261/776 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FKLCWKNFQDNIASGFQNLYDRGDLVDVTLACDGKLLHAHKIVLAICSPYFQEIFTTNPCKHPII 69
            |.|.|.|.|.|:.|.|..|.......|||||.:|:.|.|||:||:.|||||..:|.::|.||||:
  Fly     8 FCLRWNNHQSNLLSVFDQLLHAETFTDVTLAVEGQHLKAHKMVLSACSPYFNTLFVSHPEKHPIV 72

  Fly    70 ILKDVSFNIMMELLEFMYQGVVNVKHTELQSFMKIGQLLQIKGLATNSNSSP---------GSSV 125
            |||||.::.|..||:|||:|.|:|....|.:|:::.:.|:||||...::..|         |::.
  Fly    73 ILKDVPYSDMKSLLDFMYRGEVSVDQERLTAFLRVAESLRIKGLTEVNDDKPSPAAAAAGAGATG 137

  Fly   126 SEKSSSQP----------PAEESSN-----TNSTNHHNSSTNSNNNSKSETDHNESKGQSNSRTT 175
            ||.:::.|          |....|.     .::.|..|:.|.....|...:.....:.:...|..
  Fly   138 SESTATTPQLQRIQPYLVPQRNRSQAGGLLASAANAGNTPTLPVQPSLLSSALMPKRKRGRPRKL 202

  Fly   176 SPGGASRASNDASHLYTSNKRPMPSDFGSDSLSIYSGKQLRRSLKDHGSGGSEGGGGDHADTAAG 240
            | |.::...||.......|.....||.|       :||....|.     .|::.|..|:...|..
  Fly   203 S-GSSNGTGNDYDDFDRENMMNDSSDLG-------NGKMCNESY-----SGNDDGSDDNQPNAGH 254

  Fly   241 LDNSMNSEEFFLPPIPQITMGEQRYDLGGLKRESDGHHHGPLSAGGGNSGSV------------- 292
            .|: :|.....||.                ||..:...|..:|....||.||
  Fly   255 TDD-LNESRDSLPS----------------KRSKNSKDHRVVSHHEDNSTSVTPTKATPELSQRL 302

  Fly   293 -GSLTSSASPSAPIRNPFAPNFMDSFNYYKGGNSSGPSGSSNNSVGPGGVNNNGSVGLGSGAEYP 356
             ||.:::.|.:||                 ||:|:|||
  Fly   303 FGSSSTTISATAP-----------------GGSSTGPS--------------------------- 323

  Fly   357 NELYMPNDYSKSFANHMDIPSSGSNMVMLSTTSLLHGNCVFNRNNTVATQQGMKTYWLCKSYRIS 421
                                         .|.|||                           .||
  Fly   324 -----------------------------ETISLL---------------------------EIS 332

  Fly   422 MCRARCITHLGRI--ISATGVHNHTPHMRGGQGSSAPSTASVSGNPAPTPISSQAGYSLTDGGGH 484
            ..|.....||..|  :....::..||..:|     :|.|.:.|.........|....||
  Fly   333 DERESAPVHLPTILGLKIRAINTTTPAQQG-----SPQTPTKSKPKIRQATGSNNSNSL------ 386

  Fly   485 LGPDLQHGNRVTNMFANQTPPPPPPPPPLPVASTPHHPHHHHHLGQPLP-------NLLVQHHPA 542
            |...|:.|.:         .|..||...:..|.||:...:.....:.:|       |..:..|..
  Fly   387 LKQQLRGGAK---------DPEVPPATRITGAVTPNAALNAEEQSKEMPKKNQDEVNACIGLHSL 442

  Fly   543 PSHMEQHG---SSASLLHNPNLMHLQ------TPTHHHQQQHHQQHSP----------------- 581
            .:..||..   :|...||:..|:|:.      ..|.::|||  ||.||
  Fly   443 ANAAEQQAAQVASTGNLHHQLLLHMAANNSMLNTTDYYQQQ--QQESPSSAGQFMDDDLELLSLN 505

  Fly   582 ----------HNPPPPQQHNLELGGGSGSGAVLLSPAHLQQSPQSNRSSHSLQAQSPPPQSVEE- 635
                      |........|..|.|..|:.|. .:||. :.||    ::.:..|..|.|:|.::
  Fly   506 DQQDKSDEPDHEMVTLADENAGLPGYQGNEAE-ATPAQ-EDSP----AAETATAPPPAPRSGKKG 564

  Fly   636 -QQPHQQQQQQQEGATT-----EVTTDPST--------AHVINSI-----TISPNTRHTFK 677
             ::|.|:::.:::..:|     |..|:.|.        |.|:..:     ....|.:.|||
  Fly   565 AKRPIQRRRVRRKAQSTLDDQAEHLTEMSVRGLDLFRYASVVEGVYRCTECAKENMQKTFK 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34376	NP_732741.1	BTB	20..113	CDD:279045	44/92 (48%)
		BTB	31..115	CDD:197585	44/83 (53%)
		FLYWCH	390..443	CDD:282369	8/54 (15%)
ttk	NP_001189329.1	BTB	23..119	CDD:279045	46/95 (48%)
		BTB	34..119	CDD:197585	44/84 (52%)
		C2H2 Zn finger	612..638	CDD:275370	4/14 (29%)
		zf-C2H2_4	646..669	CDD:290605
		C2H2 Zn finger	648..669	CDD:275370
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9675
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.020