DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34376 and lola

DIOPT Version :9

Sequence 1:	NP_732741.1	Gene:	CG34376 / 42638	FlyBaseID:	FBgn0085405	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_788308.3	Gene:	lola / 44548	FlyBaseID:	FBgn0283521	Length:	970	Species:	Drosophila melanogaster

Alignment Length:	826	Identity:	179/826 - (21%)
Similarity:	271/826 - (32%)	Gaps:	249/826 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDDEFKLC--WKNFQDNIASGFQNLYDRGDLVDVTLACDGKLLHAHKIVLAICSPYFQEIFTTNP 63
            |||:.:.|  |.|.|..:.|.|..|.:...|||.|||.:||.|.|||:||:.|||||..:.....
  Fly     1 MDDDQQFCLRWNNHQSTLISVFDTLLENETLVDCTLAAEGKFLKAHKVVLSACSPYFATLLQEQY 65

  Fly    64 CKHPIIILKDVSFNIMMELLEFMYQGVVNVKHTELQSFMKIGQLLQIKGLATN------------ 116
            .||||.|||||.:..:..::::||:|.||:...:|.:.:|..:.||||||:.|
  Fly    66 DKHPIFILKDVKYQELRAMMDYMYRGEVNISQDQLAALLKAAESLQIKGLSDNRTGGGVAPKPES 130

  Fly   117 -----------------------------------SNSSPGSS---------------------- 124
                                               |.|..|||
  Fly   131 SGHHRGGKLSGAYTLEQTKRARLATGGAMDTSGDVSGSREGSSSPSRRRRKVRRRSMENDAHDNS 195

  Fly   125 ---------------------------VSEKSSSQPPAEESSNTNSTNHHNSSTNSNNNSKSETD 162
                                       |:.:.||.|.|..||..:||......|::|...|:|:
  Fly   196 NSSVLQAAASNQSILQQTGAGLAVSALVTTQLSSGPAAGTSSQASSTQQQQPLTSTNVTKKTES- 259

  Fly   163 HNESKGQSNSRTTSPGGASRASNDASHLYTSNKRPMPSDFGSDSLSIYSGKQLRRSLKDHGSGGS 227
               :|..|::...:.|.::.|:...:||:....:..     ||:::       ..:::....||:
  Fly   260 ---AKLTSSTAAPASGASASAAVQQAHLHQQQAQTT-----SDAIN-------TENVQAQSQGGA 309

  Fly   228 EGGGGDHAD----TAAGLDNSMNSEEFFLPPIPQITMGEQRYDLGGLKRESDGHHHGPLSAGGGN 288
            :|..||..|    :|.|..||.............:..|.....|..:..:|..:|...:     .
  Fly   310 QGVQGDDEDIDEGSAVGGPNSATGPNPASASASAVHAGVVVKQLASVVDKSSSNHKHKI-----K 369

  Fly   289 SGSVGSLTSS--ASPSAPIRNPFAPNFMDSFNY-----------YKGGNSSGPSGSSNNSVGPGG 340
            ..||.|:.|.  ..|.|...:......::....           ...|.|.|..|||........
  Fly   370 DNSVSSVGSEMVIEPKAEYDDDAHDENVEDLTLDEEDMTMEELDQTAGTSQGGEGSSQTYATWQH 434

  Fly   341 VNNNGSVGL-GSGAEYPNELYMPNDYSKSFANHMDIPSSGSNMVMLSTTSLLHGNCVFNRNNTVA 404
            ..:...:|| ...|:..:......|..:......|              .....:|:...|:.|.
  Fly   435 DRSQDELGLMAQDAQQRDPQASKQDKGEQTEGAQD--------------EFELDDCLLESNDIVI 485

  Fly   405 TQ--QGMKTYWLCKSYRISMCRARCITHLGRIISATGVHNHTPHMRGGQGSSAPSTASVSGNPAP 467
            ||  .|...:               :..||.|.:|....|.....:  ||.:|.:....:|.|.|
  Fly   486 TQNKDGFVLH---------------VKKLGNITAAKLEENQAVAQQ--QGQAAVTVTGPAGQPTP 533

  Fly   468 TPISSQAGYSLTDGGGHLGPDLQHGNRVTNMFANQTPPPPPPPPPL-PVASTP------------ 519
            |                          :|.:..........|.|.| .:.|||
  Fly   534 T--------------------------ITELLNAAAASHSEPKPTLTTLTSTPIKLPSSECELIN 572

  Fly   520 -------------HHPH------HHHHLGQPLPNLLVQHHPAPSHMEQHGSSASLLHNPNLMHLQ 565
                         ||||      |.||        ::||.....|.::|......:|...:.  |
  Fly   573 IKKIIPATTTIATHHPHTSSTIIHPHH--------IIQHVSQEPHHQEHHQQHQTIHIEEVP--Q 627

  Fly   566 TPTHHHQQQHHQQHSPHNPPPPQ-QHNLELGGGSGSGAVLLSPAHLQQS-PQSNRSSHSLQAQSP 628
            |...|||||||.|.....|...| |..:....|.....|.|....|..| |.::|..:|......
  Fly   628 TSQQHHQQQHHHQLQTVQPTHTQVQSIITAHPGQTINLVGLRNVQLADSKPIASRIRYSRGKIIG 692

  Fly   629 PP----QSVEEQQPHQQQQQQ-QEGATTEVT----TDPSTAHVINS 665
            |.    |.||..:|.|.|..: .:|...|::    .:|:.:..|.|
  Fly   693 PTVQNLQIVETHEPIQHQHHELSDGTKYEISEIDLNNPNASAAIIS 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34376	NP_732741.1	BTB	20..113	CDD:279045	41/92 (45%)
		BTB	31..115	CDD:197585	39/83 (47%)
		FLYWCH	390..443	CDD:282369	10/54 (19%)
lola	NP_788308.3	BTB	22..117	CDD:279045	43/94 (46%)
		BTB	33..117	CDD:197585	39/83 (47%)
		C2H2 Zn finger	905..925	CDD:275368
		C2H2 Zn finger	935..955	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9675
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	4.010