DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34376 and br

DIOPT Version :9

Sequence 1:	NP_732741.1	Gene:	CG34376 / 42638	FlyBaseID:	FBgn0085405	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001162638.2	Gene:	br / 44505	FlyBaseID:	FBgn0283451	Length:	1011	Species:	Drosophila melanogaster

Alignment Length:	782	Identity:	197/782 - (25%)
Similarity:	287/782 - (36%)	Gaps:	247/782 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDD--EFKLCWKNFQDNIASGFQNLYDRGDLVDVTLACDGKLLHAHKIVLAICSPYFQEIFTTNP 63
            |||  .|.|.|.|:|.:|.|.|:||.|....|||||||:|:.:.||::||:.|||||:|:..:.|
  Fly     1 MDDTQHFCLRWNNYQSSITSAFENLRDDEAFVDVTLACEGRSIKAHRVVLSACSPYFRELLKSTP 65

  Fly    64 CKHPIIILKDVSFNIMMELLEFMYQGVVNVKHTELQSFMKIGQLLQIKGLA-------------- 114
            ||||:|:|:||:|..:..|:||:|.|.|||....||||:|..::|::.||.
  Fly    66 CKHPVILLQDVNFMDLHALVEFIYHGEVNVHQKSLQSFLKTAEVLRVSGLTQQQAEDTHSHLAQI 130

  Fly   115 -------------TNSNSSP-----------GSSV---SEKSSSQPPAEESSNTNSTNH------ 146
                         |::.|.|           |||.   .:.:.|.||....|..:..|:
  Fly   131 QNLANSGGRTPLNTHTQSLPHPHHGSLHDDGGSSTLFSRQGAGSPPPTAVPSLPSHINNQLLKRM 195

  Fly   147 ---HNSSTNSNNNSKSETDH--NESKGQSNSRTTSPGGASRASNDAS------HLYTSNKRPMPS 200
               |.||..:   :..||.|  ...:|..||...| |.....||:.|      |..:::.:..|:
  Fly   196 AMMHRSSAAA---AAEETSHAFKRLRGSDNSLPLS-GAVGSGSNNNSPDLPPLHARSASPQQTPA 256

  Fly   201 DFGSDSLSIYSGKQLRRSLKDHGSGGSEGGGGDHADTAAGLDNSMNSEEFFLPPIPQITMGEQRY 265
            ||.              ::|.|                    |:.|:     ||:.:    |:|.
  Fly   257 DFS--------------TIKHH--------------------NNNNT-----PPLKE----EKRN 278

  Fly   266 DLGGLKRESDGHHHGPLSAGGGNSGSVGSLTSSASPSAPIRNPFAPNF----MD--------SFN 318
            ...|.....:|:.:|. .|..||..|:.....|.:|| |:....|.:.    ||        :.|
  Fly   279 GPTGNGNSGNGNGNGN-GASNGNGISISDKLGSLTPS-PLARAGADDVKSEPMDMVCSNNNANAN 341

  Fly   319 YYKGGNSSGPSGSSNNSVGPGG-----VNNNGSVGLGSGAEY----------PNELY------MP 362
            .....:|:|...::.:|.|.||     ..|:..:|.|..:.:          .|:::      .|
  Fly   342 DEHSNDSTGEHDANRSSSGDGGKGSLSSGNDEEIGDGLASHHAAPQFIMSPAENKMFHAAAFNFP 406

  Fly   363 N-DYSKSFANHMDIPSSGSNMVML---STTSLLHG------------NCVFNRNNTVATQQGMKT 411
            | |.|.....:..:..||...|..   ||.|||.|            |...|.||..:..|..|.
  Fly   407 NIDPSALLGLNTQLQQSGDLAVSPQGGSTGSLLSGVIVPGGSGGTPSNSSSNNNNNNSNNQQQKV 471

  Fly   412 YWLCKSYRISMCRARCITHLGRIISATGVHNHTPHM----------RGGQGSSAPSTASV-SGNP 465
            ......:::...:                |:.|||.          :.|.||...|...: :|:.
  Fly   472 EQQSSPHQLLQQQ----------------HHSTPHTNSPQLKQEQPKSGGGSCKSSDLHIAAGSE 520

  Fly   466 APTPISSQAGYSLTDGGGHLGP----------------------------DLQHGNRVTNMFANQ 502
            .....|||   .:.|.|||...                            .|.|...:.......
  Fly   521 RSLSRSSQ---GMPDAGGHSATPSPTAAYHKRERERERERERERERERERSLDHERDLERPGGTG 582

  Fly   503 TPPPPPPPPPLPVASTPHHPHHHHHLGQPLPNLLVQHHPAPSHMEQHGSSASLLHNPN------- 560
            :|||||             |.||.|.||...:||..||..  |...|..||:..|:.:
  Fly   583 SPPPPP-------------PSHHSHFGQHPLSLLPSHHQL--HATHHELSAAAAHHAHAHAHAAH 632

  Fly   561 ---LMHLQTPTHHHQQQHHQQH--SPHNPPPPQQHNLELGGGSGS----GAVLLSPAHLQQSPQS 616
               |....:|..||...||::.  ||.............|||:|.    |..|||....|...|:
  Fly   633 AHALARAGSPMEHHHLLHHRRASLSPSGAVSSASGAGGRGGGAGGPGGPGGSLLSSVRAQDVAQA 697

  Fly   617 NR 618
            ||
  Fly   698 NR 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34376	NP_732741.1	BTB	20..113	CDD:279045	46/92 (50%)
		BTB	31..115	CDD:197585	43/110 (39%)
		FLYWCH	390..443	CDD:282369	10/64 (16%)
br	NP_001162638.2	BTB	22..118	CDD:279045	48/95 (51%)
		BTB	33..118	CDD:197585	43/84 (51%)
		C2H2 Zn finger	712..729	CDD:275368
		C2H2 Zn finger	742..763	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9606
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.020