DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34376 and bab2

DIOPT Version :9

Sequence 1:	NP_732741.1	Gene:	CG34376 / 42638	FlyBaseID:	FBgn0085405	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_523879.2	Gene:	bab2 / 44254	FlyBaseID:	FBgn0025525	Length:	1067	Species:	Drosophila melanogaster

Alignment Length:	809	Identity:	182/809 - (22%)
Similarity:	268/809 - (33%)	Gaps:	296/809 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EFKLCWKNFQDNIASGFQNLYDRGDLVDVTLACDGKLLHAHKIVLAICSPYFQEIFTTNPCKHPI 68
            :|.|.|.|:|.|:.:.|..|......|||||:|:|..:.|||:||:.||||||.:|..|||:|||
  Fly   197 QFCLRWNNYQSNLTNVFDELLQSESFVDVTLSCEGHSIKAHKMVLSACSPYFQALFYDNPCQHPI 261

  Fly    69 IILKDVSFNIMMELLEFMYQGVVNVKHTELQSFMKIGQLLQIKGL-------------------- 113
            ||::|||::.:..|:||||:|.:||...::...:|:.:.|:|:||
  Fly   262 IIMRDVSWSDLKALVEFMYKGEINVCQDQINPLLKVAETLKIRGLAEVSAGRGEGGASALPMSAF 326

  Fly   114 --------------------------------------------------------ATNSNSSPG 122
                                                                    ||.|.|..|
  Fly   327 DDEDEEEELASATAILQQDGDADPDEEMKAKRPRLLPEGVLDLNQRQRKRSRDGSYATPSPSLQG 391

  Fly   123 --SSVSEKSSSQPPAEESS------------------NTNSTNHHNSSTNSNNN---SKSETDHN 164
              |.:||:.||..|.:..|                  |..:....||:.|:..|   |.:.|...
  Fly   392 GESEISERGSSGTPGQSQSQPLAMTTSTIVRNPFASPNPQTLEGRNSAMNAVANQRKSPAPTATG 456

  Fly   165 ESKGQSNSRTTS-PGGASRASNDASHLYTSNKRPMPSDFGSDSLSIYSGKQLRRSLKDH------ 222
            .|.|.|.:...| |||.:..|....|: .:...|.||.....:..:.:..||..|   |
  Fly   457 HSNGNSGAAMHSPPGGVAVQSALPPHM-AAIVPPPPSAMHHHAQQLAAQHQLAHS---HAMASAL 517

  Fly   223 ----------GSGGSEGGGGDHADTAAG-----------LDNSMNSEEFFLPPIPQITMGEQRYD 266
                      |:||:..|.|..|....|           ...|.:.:....|.|.::...|:|..
  Fly   518 AAAAAGAGAAGAGGAGSGSGSGASAPTGGTGVAGSGAGAAVGSHHDDMEIKPEIAEMIREEERAK 582

  Fly   267 LGGLKRESDGHHHGPLSAGGGNSGSVGSLTSSASPSAPIRNPFAPNFMDSFNY------YKGGNS 325
            :    .||.||        ||..|:..:.|.:||.:|           ||:.|      .|..|:
  Fly   583 M----IESGGH--------GGWMGAAAAATGAASVAA-----------DSYQYQLQSMWQKCWNT 624

  Fly   326 SGPSGSSNNSVGPGGVNNNGSVGLGSGAEYPNELYMPNDYSKSF-------------ANHMDIPS 377
                 :..|.|........|          |.:.:.|...:::.             |...|||
  Fly   625 -----NQQNLVQQLRFRERG----------PLKSWRPEAMAEAIFSVLKEGLSLSQAARKFDIP- 673

  Fly   378 SGSNMVMLSTTSLLHGNCVFN----------------RNNTVATQQGMKTYWLCKSYRISMCRAR 426
                    ..|.:|:.|.|.|                |........||   |..:..| |:.:|.
  Fly   674 --------YPTFVLYANRVHNMLGPSLDGGADPRPKARGRPQRILLGM---WPEELIR-SVIKAV 726

  Fly   427 CITHLGRIISATGVHNHTPHMRGGQGSSAPSTASVSGNPAPTPISSQAGYSLTDGGGHLGPDLQH 491
            .......|......|.:.    .|||.                 .:..|...|..|.|
  Fly   727 VFRDYREIKEDMSAHQYA----NGQGH-----------------GTYIGGGTTTNGYH------- 763

  Fly   492 GNRVTNMFANQTPPPPPPPPPLPVASTPHHPHHHHHLGQPLPNLLVQHHPAPSHMEQHGSSASLL 556
             :......|.|.....||....|::|          :.:.|...::      |..:||
  Fly   764 -SAAAAKLAAQNAALAPPDAGSPLSS----------MTETLRRQIL------SQQQQH------- 804

  Fly   557 HNPNLMHLQTPTHHHQQ-QHHQQHSPHNPPPPQQHNLELGGGSGSGAVLLSPAHLQQSPQSNRSS 620
                ..|.|...||.|| .||||.|||    .|..|:           ..|||:||:|...::.|
  Fly   805 ----QQHHQQQAHHQQQPSHHQQQSPH----AQSMNM-----------YKSPAYLQRSEIEDQVS 850

  Fly   621 HSLQAQSPPPQSVEEQQPHQQQQQQQEGA 649
            .:....:...:       |||||.::.|:
  Fly   851 AAAAVAAAAAK-------HQQQQGERRGS 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34376	NP_732741.1	BTB	20..113	CDD:279045	43/92 (47%)
		BTB	31..115	CDD:197585	42/159 (26%)
		FLYWCH	390..443	CDD:282369	13/68 (19%)
bab2	NP_523879.2	BTB	213..309	CDD:279045	45/95 (47%)
		BTB	224..309	CDD:197585	42/84 (50%)
		HTH_psq	645..690	CDD:283007	10/53 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447056
Domainoid	1	1.000	69	1.000	Domainoid score	I9606
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	80	1.000	Inparanoid score	I5230
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.990