DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34376 and CG6765

DIOPT Version :9

Sequence 1:	NP_732741.1	Gene:	CG34376 / 42638	FlyBaseID:	FBgn0085405	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001261582.1	Gene:	CG6765 / 38971	FlyBaseID:	FBgn0035903	Length:	681	Species:	Drosophila melanogaster

Alignment Length:	814	Identity:	148/814 - (18%)
Similarity:	242/814 - (29%)	Gaps:	295/814 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DEFKLCWKNFQDNIASGFQNLYDRGDLVDVTLACDGKL-----------LHAHKIVLAICSPYFQ 56
            :.:.|.|.:....:.|....||......||.|......           :.|||.:|:..|.:|.
  Fly     4 ENYHLKWDSHLTYLNSSIATLYKNEKFADVVLYSSYNSSGIPSDIPTVGISAHKFILSASSQFFA 68

  Fly    57 EIFTTNPCKHP-----IIILKDVSFNIMMELLEFMYQGVVNVKHTELQSFMKIGQLLQIKGLATN 116
            .:|.|.|..:|     :::..|:|...:..|:::||.|...|.:..|...::.|::|:|:||...
  Fly    69 TMFETAPITNPNGVLYVVLPPDLSHRAIQILVQYMYSGEATVSNDILNEVLRGGEILKIRGLCRT 133

  Fly   117 SNSSPGSSVSEKSSSQPPAEESSNTNSTNHHNSSTNSNNNSKSETDHNESKG------------- 168
            |:|:.|.              |.:..:|.||..|...:.:.:..:....|.|
  Fly   134 SSSNGGG--------------SGSVVTTTHHPHSLAGHLHPREASTMYMSNGTRTALPPPPPPPQ 184

  Fly   169 -------QSNSRTTSPGGASRASNDASHL-----YTSNKRP-----------MPSD--------- 201
                   |.:...:.|||::|.:.|..||     :.::..|           ||.|
  Fly   185 STMSAQLQGDLYASKPGGSTRFALDHHHLSSHHSHLNHHNPQQQFRGLGASVMPKDSPVIIKSPK 249

  Fly   202 ----------FGSDSLSIYSGKQLRRSLKDH--------------------------GSGGSEGG 230
                      ..|..|.|...|::....:|.                          |.|||.||
  Fly   250 LAAHTGLLTVASSSKLGISVNKEVAIDPEDKCCFAAPGQLESQSHPPPPTTTTTTVGGGGGSVGG 314

  Fly   231 GGDHADTAAGLDNSMNSEEFFLPPIPQITMGE--------------QRYDLG-----GLKRE--- 273
            .|........:...:......|...|.....|              :|.::|     .|:||
  Fly   315 SGAPPSQPISICTEVGCSSCPLTAGPGADQAETTLRRTEYEEQALRERNEVGLVFERRLRRESAC 379

  Fly   274 --SDGHHHGPLSAGGGNSGSVGSLTSSASPSAP-----------IRNPFAPNFMDSFNYYKGGNS 325
              |..::..|      :...|.|...:|:|..|           :|:|.  ||:..        .
  Fly   380 ERSRDYYEAP------HFEHVVSSRLAATPPPPPQQAPPSHPPTLRHPH--NFLTI--------K 428

  Fly   326 SGPSGSSNNSVGPGGVNNNGSVGLGSGAEYPNELYM-----PNDYSKSFANHMDI------PSSG 379
            ..|:..|||.......:||.::         .||.:     |.|:..| |..:::      ||..
  Fly   429 QEPTDWSNNPPNASSASNNNNL---------EELPLASPKQPLDFKMS-AVKLEVNRDRGTPSEE 483

  Fly   380 SNMVMLSTTSLLHGNCVFNRNNTVATQQGMKTYWLC----KSYRISMCRARCITHLGRIISATGV 440
            |                  ..:|:......|...:|    ||:..:....|   |||
  Fly   484 S------------------EEHTLRDYNNFKQLLVCEICQKSFEDTKMLVR---HLG-------- 519

  Fly   441 HNHTPHMRGG------QGSSAPSTASVSGNPAPTPISSQAGYSLTDGGGHLGPDLQHGNRVTNMF 499
             .|.....||      ..|::.||.|.|.|.|...:.:...              :...||:...
  Fly   520 -THAGDPTGGTERNLLPSSASGSTTSASSNLALRSVKTYVP--------------KKRRRVSQQE 569

  Fly   500 ANQTPPPPPPPPPLPVASTPHHPHHHHHLGQPLPNLLVQHHPAPSHMEQHGSSASLLHNPNLMHL 564
            .|.                   .|.|..|   |.:|.......|:...:|         .|..|.
  Fly   570 NNM-------------------DHDHVTL---LCDLCSTSFDTPAEWVRH---------MNSQHT 603

  Fly   565 QTPTHHHQQQHHQQHSPHNPPPPQQHNLELGGGSGSGAVLLSPAHLQ---QSPQSNRSSHSLQAQ 626
            :........:...:.....||||.         :.|.:..:|.:.:|   .|..:.||:|||..
  Fly   604 EIELAMFNSKKDGEQKGQQPPPPP---------ATSSSSTVSNSQMQPKYPSSTATRSTHSLML- 658

  Fly   627 SPPPQSVEEQQPHQQQQQQQEGATTE--VTTDPS 658
                        |:.........||.  .:|.|:
  Fly   659 ------------HKMSNSDAVATTTSPGASTSPN 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34376	NP_732741.1	BTB	20..113	CDD:279045	26/108 (24%)
		BTB	31..115	CDD:197585	26/99 (26%)
		FLYWCH	390..443	CDD:282369	9/56 (16%)
CG6765	NP_001261582.1	BTB	24..132	CDD:279045	28/107 (26%)
CG6765	NP_001261582.1	BTB	53..130	CDD:197585	21/76 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451894
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940