DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34376 and lov

DIOPT Version :9

Sequence 1:	NP_732741.1	Gene:	CG34376 / 42638	FlyBaseID:	FBgn0085405	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_611994.3	Gene:	lov / 38007	FlyBaseID:	FBgn0266129	Length:	1143	Species:	Drosophila melanogaster

Alignment Length:	749	Identity:	162/749 - (21%)
Similarity:	251/749 - (33%)	Gaps:	231/749 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 DEFKLCWKNFQDNIASGFQNLYDRGDLVDVTLACDGKLLHAHKIVLAICSPYFQEIFTTNPCKHP 67
            |.:.|.|.|.|::|...|..|.....||||||.|....:.|||:||:.|||:||.:|...|||||
  Fly   113 DHYSLRWNNHQNHILRAFDALLKTKTLVDVTLVCAETSIRAHKMVLSACSPFFQRVFAETPCKHP 177

  Fly    68 IIILKDVSFNIMMELLEFMYQGVVNVKHTELQSFMKIGQLLQIKGLATNS----NSSPGSS---- 124
            :|:|||....::..:::|||:|.::|....||:.::.|:.||::||..:|    ..:|.:|
  Fly   178 VIVLKDFRGWVVQAIVDFMYRGEISVPQQRLQTLIQAGESLQVRGLVESSVPEHTPTPAASPDDF 242

  Fly   125 ----VSEKSSS------------------QPPAEESSNTNSTNHHNSSTNSNNNSKSETDHNESK 167
                .|..||:                  .|.|....|.:|.   .::.......:.|:|.:...
  Fly   243 GMLDTSMLSSTFEDECPTMVRPSKGGKLLMPSARLFGNASSA---IAALGLRRKREQESDRDLES 304

  Fly   168 GQSNSRTTSPGGAS-----------RASNDASHLYTSNKRPMPSDFGSDSL-SIYSGKQLRRSLK 220
            .|      ..||:|           |.|.|..|.:|.||.      .::|| ::...:.|.|:.:
  Fly   305 DQ------ELGGSSPMPRRKQARPRRRSGDVPHDFTLNKT------DAESLQTVIKHELLERAER 357

  Fly   221 DHGSGGSEGGGGDHADTAAGLDNSMNSEEFFLPPIPQITMGEQRYDLGGLKRE--------SDGH 277
            |.             :.|...|||....| .:...|..|:.|:..:...:|.|        ::.|
  Fly   358 DQ-------------EEAPDQDNSQGEAE-KISSSPAKTLVERAKEQKSMKEEGSDQPRSLNENH 408

  Fly   278 HHGPLSAGGGNS----------------------GSVGSLTSSASPSAPIRNPFAPNFMDSFNYY 320
            |...|.....:.                      ....:..::|:..:|..:|...:..:.....
  Fly   409 HQLELDDEDDDDQDHEEEEEQDIEELIHTTNELRRQAAAAAANAAAMSPNPSPCLSDGPEDLCTT 473

  Fly   321 KGGNS--SGPSGS----SNNSVGPGGVNNNGSVGLG-------SGAEYPNELYMPNDYSKSFANH 372
            |.|..  ||||.|    |||:......:||..:.|.       :....|..::.|...|......
  Fly   474 KKGKELISGPSSSADCESNNNNSSKLQDNNQRIMLSLKDIRQLNANPNPTAIHTPTSCSGGNNGL 538

  Fly   373 MDIPSSGSNMVMLSTTSLLHGNCVFNRNNTVATQQGMKTYWLCKSYRISMCRARCITH------- 430
            :..|..|.....|..:...|...:..:.:..|.              .::..|....|
  Fly   539 LTFPPPGLRPPGLPDSPPCHMEALEAQMHAAAA--------------AAVAAAGSGEHPFHHMEH 589

  Fly   431 -----LGRIISATGVHNHTP---------------------------HMRGGQGSSAPSTASVSG 463
                 |....:|..:|...|                           |..|..|:|.|      |
  Fly   590 QMEMSLAAAAAAAAMHQREPRDPRDGRDHNAFASNLLGPMGMPPFGGHNGGHPGNSGP------G 648

  Fly   464 NPAPTPISSQAGYS-LTDGGGHLGPDL--QHGNRVTNMFANQTPP---------------PPPPP 510
            |..|    .||.:. |.:....|..:|  :.|......|..:..|               ||.||
  Fly   649 NGCP----GQAAHERLEESMNRLSKELGKEFGKEFGKEFGKEFGPASPMSLQGPFNAPDGPPHPP 709

  Fly   511 PPLPV----ASTPHHPHHHHHLGQPLPNLLVQHHPAPSHMEQHGSSASLLHNPNLMHLQTPTHHH 571
            .|||.    ::....|.|...|..||            .:...|.....|:|| ||.:..|
  Fly   710 SPLPFPGMSSAMTLTPPHMFGLDSPL------------GLFPPGIDPGKLYNP-LMEMSDP---- 757

  Fly   572 QQQHHQQHSPHNPPP--------PQ-QHNLELGG 596
                  :..|..|||        |: ||:...||
  Fly   758 ------RDMPGGPPPFLKKKMPRPKGQHSAPRGG 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34376	NP_732741.1	BTB	20..113	CDD:279045	39/92 (42%)
		BTB	31..115	CDD:197585	37/83 (45%)
		FLYWCH	390..443	CDD:282369	7/64 (11%)
lov	NP_611994.3	BTB	130..225	CDD:279045	41/94 (44%)
		BTB	141..226	CDD:197585	37/84 (44%)
		HTH_psq	791..834	CDD:283007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9675
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.020