DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34376 and ab

DIOPT Version :9

Sequence 1:	NP_732741.1	Gene:	CG34376 / 42638	FlyBaseID:	FBgn0085405	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_476562.1	Gene:	ab / 34560	FlyBaseID:	FBgn0264442	Length:	904	Species:	Drosophila melanogaster

Alignment Length:	837	Identity:	193/837 - (23%)
Similarity:	292/837 - (34%)	Gaps:	283/837 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FKLCWKNFQDNIASGFQNLYDRGDLVDVTLACDGKLLHAHKIVLAICSPYFQEIFTTNPCKHPII 69
            :.|.|.:||.:|.|.|::|.|..|.||||||||.:...|||:||:.|||||:.:...|||:|||:
  Fly    78 YALKWNDFQSSILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKANPCEHPIV 142

  Fly    70 ILKDVSFNIMMELLEFMYQGVVNVKHTELQSFMKIGQLLQIKGLATNSNSSPGSSVSEKSSSQPP 134
            ||:||..:.:..||.|||.|.|||.|.:|..|:|...||||:|||..:...|.|.....:.|...
  Fly   143 ILRDVRCDDVENLLSFMYNGEVNVSHEQLPDFLKTAHLLQIRGLADVNGGYPYSKALSAALSHNS 207

  Fly   135 AEESSNTNSTNHHNSSTNSNNNSKSE-TDHNESKGQSNSRTTSPGGASRASNDASHLYTSNKRPM 198
            :..::|.:|:|:..|:.|:|||:.:| ::||:.     |...||...|.|.|::|:..::|....
  Fly   208 SNNNNNNSSSNNSLSNNNNNNNNNAESSNHNKI-----SSYLSPNQTSAACNNSSNSNSNNHSSS 267

  Fly   199 PSDFGSDSLSIYSGKQLRRSLKDHGSGGSEGGGGDHADTAAGLDNSMNSEEFFLPPIPQITMGEQ 263
            .::..|:::|                 ||             |::|:|| .|..|.||.......
  Fly   268 HNNSSSNNIS-----------------GS-------------LNSSLNS-PFSAPQIPPPVTASS 301

  Fly   264 RYDLGGLKRESDGHHHGPLSAGGGNSGSVGSLTS-------------SASPSAPIRNPFA-PNFM 314
            ...................:|...::||..|..|             ::|.::|:|||.. |:..
  Fly   302 AAAAAAAAASLTAAVAAAAAATAASAGSSSSAASGQTSGTPAIQELKASSAASPVRNPNPNPSKA 366

  Fly   315 DSFNYYKGG---------------------------------------------------NSSGP 328
            .|.|::..|                                                   |.||.
  Fly   367 SSSNHWDMGEMEGSRKSHLTPPPQKRIKSADLFRAQHGISPERLLLDREFPVAGQHPLTRNRSGR 431

  Fly   329 SGSSNNS---------VGPGGVNNNG-------SVGLGSGAEYPNELYMPND------------- 364
            ..|.:..         :|....|:||       .:|..:|.:..:....|:|
  Fly   432 DTSKDRERNLELRESLLGQALENSNGQQANPKHELGQSAGEDSNSSDTEPSDRGDGQHDGTLDGI 496

  Fly   365 -------YSKSFANHMDIPS-----SGSNMVMLSTTSLLH----------GNC--VFNRNNTVAT 405
                   :..:|.....||.     ||.|...:|..||..          ..|  ::...:|:.|
  Fly   497 DNQRSHSFPNAFLGLQGIPGLLPGPSGINSDFVSRRSLEMRVRATDPRPCPKCGKIYRSAHTLRT 561

  Fly   406 QQGMKTYWLCKSYRISMC----RARCITH----------------------------LGRIISAT 438
            ....| :.:|..||..:|    ::|...|                            ..|:::..
  Fly   562 HLEDK-HTVCPGYRCVLCGTVAKSRNSLHSHMSRQHRGISTKDLPVLPMPSAFDPELASRLLAKA 625

  Fly   439 GVHNHTPHMR------GGQGSSAP-----------STASVSGNPA-PTPISSQAGYSLTDGGGHL 485
            ||......:|      ||.|||..           ..::.||.|. ....|......||.|.|..
  Fly   626 GVKISPAELRARASPTGGSGSSGGGGGGGSSQAKLDLSNASGGPMDDAEDSDDDPEDLTTGNGLY 690

  Fly   486 G-----PDLQ--HGNRVTNM----FANQTPPPPPPPPPLPVASTPHHPHHHHHLGQPLPNLLVQH 539
            |     .||.  |.:.::|.    ..|:.         ..||:|.........||..|||   .:
  Fly   691 GMGGSSSDLSRYHESLLSNFGHARMRNEA---------AAVAATAAALGQPKDLGVQLPN---SN 743

  Fly   540 HPAPS----------------HMEQHGSSASLLHNPNLMHLQTPTHHHQQQHHQQHSPHNPPP-- 586
            .|..|                .|.|..::|:.|.           ....|.:...||..|.||
  Fly   744 APGQSLLDTYLQFITENTFGMGMSQEQAAAAALR-----------AKMAQLNAMGHSLDNLPPGL 797

  Fly   587 -PQQHNL-ELGGGSGSGAVLLSPAHLQQSPQSNRSSHSLQAQSPPPQSVEEQQPHQQ 641
             |.|.:| :|..|        :||.               .||.|..::|....|:|
  Fly   798 LPGQFDLSKLAAG--------NPAF---------------GQSGPGLTIEPIMRHEQ 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34376	NP_732741.1	BTB	20..113	CDD:279045	49/92 (53%)
		BTB	31..115	CDD:197585	46/83 (55%)
		FLYWCH	390..443	CDD:282369	14/96 (15%)
ab	NP_476562.1	BTB	93..189	CDD:279045	52/95 (55%)
		BTB	104..189	CDD:197585	47/84 (56%)
		zf-Di19	545..597	CDD:283297	10/52 (19%)
		C2H2 Zn finger	546..567	CDD:275371	4/21 (19%)
		C2H2 Zn finger	575..596	CDD:275371	3/20 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451875
Domainoid	1	1.000	69	1.000	Domainoid score	I9606
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1229475at2759
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.950