DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34376 and NACC2

DIOPT Version :9

Sequence 1:	NP_732741.1	Gene:	CG34376 / 42638	FlyBaseID:	FBgn0085405	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_653254.1	Gene:	NACC2 / 138151	HGNCID:	23846	Length:	587	Species:	Homo sapiens

Alignment Length:	438	Identity:	87/438 - (19%)
Similarity:	139/438 - (31%)	Gaps:	140/438 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 DVTLACDGKLLHAHKIVLAICSPYFQEIFTTNPCKHPIIILKDVSFNIMMELLEFMYQGVVNVKH 95
            ||::...|:...||:.|||..|.||:::|:.| .|....:...|......::|.|.|.|.:.:..
Human    31 DVSIVVKGQAFKAHRAVLAASSLYFRDLFSGN-SKSAFELPGSVPPACFQQILSFCYTGRLTMTA 94

  Fly    96 TELQSFMKIGQLLQIKGLATNSNSSPGSSVSEKSSSQPPAEESSNTNSTNHHNSSTNSNNNSKSE 160
            :|....|.....|||:.:...     |:.:..|.||.             |.:|.|....::.||
Human    95 SEQLVVMYTAGFLQIQHIVER-----GTDLMFKVSSP-------------HCDSQTAVIEDAGSE 141

  Fly   161 TDHNESKGQSNSRTTSPGGASRASNDASHLYTSNKRPMPSDFGSDSLSIYSGKQLRRSLKDHGSG 225
            .       ||......|..|:     |:....|...|:|
Human   142 P-------QSPCNQLQPAAAA-----AAPYVVSPSVPIP-------------------------- 168

  Fly   226 GSEGGGGDHADTAAGLDNSMNSEEFFLPPIPQITMGEQRYDLGGL--KRESDGHHHGPLSAGGGN 288
                           |...:..|...|||...           ||  ||        ||..|..:
Human   169 ---------------LLTRVKHEAMELPPAGP-----------GLAPKR--------PLETGPRD 199

  Fly   289 SGSVGSLTSSASPSAPIRNPFAPNF-----------MDSFNYYKGGNSSGPSGSSNNSVGPGGVN 342
            ..:|.:..:.|:.:||::.|....:           :....|.:|..:|..:.|...:..|...:
Human   200 GVAVAAGAAVAAGTAPLKLPRVSYYGVPSLATLIPGIQQMPYPQGERTSPGASSLPTTDSPTSYH 264

  Fly   343 NNGSVGLGSGAEYPNELY---MPNDYSKSFANHMDIPSSGSNMVM--LSTTSLLHGNCVFNRNNT 402
            |...       |..:|.|   :...|.:     |.|.:|||..|.  .....|...:||..|.:.
Human   265 NEED-------EEDDEAYDTMVEEQYGQ-----MYIKASGSYAVQEKPEPVPLESRSCVLIRRDL 317

  Fly   403 VATQQGMKTYWLCKSYRISMCRARCITHLG---------RIISATGVH 441
            ||....:          ||....||...|.         .:::.:||:
Human   318 VALPASL----------ISQIGYRCHPKLYSEGDPGEKLELVAGSGVY 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34376	NP_732741.1	BTB	20..113	CDD:279045	24/81 (30%)
		BTB	31..115	CDD:197585	24/83 (29%)
		FLYWCH	390..443	CDD:282369	13/61 (21%)
NACC2	NP_653254.1	BTB	20..120	CDD:279045	25/94 (27%)
		BTB	31..114	CDD:197585	24/83 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..272		7/38 (18%)
		BEN	373..450	CDD:214981
		TIM_phosphate_binding	496..>581	CDD:304361
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	80	1.000	Inparanoid score	I5230
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.050