DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34376 and Btbd18

DIOPT Version :9

Sequence 1:	NP_732741.1	Gene:	CG34376 / 42638	FlyBaseID:	FBgn0085405	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	XP_002729248.1	Gene:	Btbd18 / 100363270	RGDID:	2323370	Length:	724	Species:	Rattus norvegicus

Alignment Length:	745	Identity:	141/745 - (18%)
Similarity:	248/745 - (33%)	Gaps:	221/745 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 GDLVDVTLACDGKLLHAHKIVLAICSPYFQE-IFTTNPCKHPIIILK--DVSFNIMMELLEFMYQ 88
            |...|..|..:|:.:.||..:|:.|||:|.| :....|.:...::|:  .:....:.:|::|:|.
  Rat    31 GVFCDALLQAEGEAVPAHCCILSACSPFFTERLERERPVQGRKVVLELGGLKIQTLRKLVDFLYT 95

  Fly    89 GVVNVKHTELQSF------MKIGQL--LQIKG--------------------------------- 112
            ..:.|...|.|..      :::.:|  ||::|
  Rat    96 SEMEVSQEEAQDVLSAARQLRVSELETLQLEGGKLVKAPQGRRLNRECLQPPSAAPISARVVVPR 160

  Fly   113 ------LATNSNSSPGSSVSEKSSSQPPAEESSN--TNSTNHHNSS-------------TNSNNN 156
                  |......||..:|..||..:   ||.::  :|..|..|.|             |...::
  Rat   161 SRPRTPLPVTQTPSPLGAVKLKSLGE---EEGAHKKSNLPNADNLSDTLLLKKKARVCLTQERSS 222

  Fly   157 SKSETDHNESKGQSNSRTTSPGGAS-------------------RASNDASHLYTSNKRPMPSDF 202
            |.|.......:.:||     ||..:                   ..|..:.|:|||....|.|
  Rat   223 SPSSQREGPKENKSN-----PGSTALPSLYPSVDEQLLPRKIRLSRSKPSPHVYTSKPSSMLS-- 280

  Fly   203 GSDSLSIYSGKQL--RRSLKDHGSGGSEGGGGDHADTAAGLDNSMNSEEFFLPPIPQITMGEQRY 265
            |..|:....|::|  :|::               ::...|:|.....|...|...|...
  Rat   281 GPSSMPTAPGRRLWRQRTV---------------SEATQGVDKQKPGEVSTLQSTPDPP------ 324

  Fly   266 DLG--GLKRESDGHHHGPLSAGGGNS---GSVGSLTS---------SASPSAPIRNPFAPNFMDS 316
            |:|  |.|::.......|.|    ||   |.||.:..         ......||||.     .||
  Rat   325 DVGKTGGKKQPSPESRAPAS----NSVEEGQVGRVKLRKIVNGTCWEVVQEPPIRNT-----QDS 380

  Fly   317 FNYYKGGNSSGPSGSSNNSVGPGGVNNNGSVGLGSGAEYPNELYMPNDYSKS--------FANHM 373
            ....:..::..|.|:..:||              :..|.|..:.:.:|..::        .|:|.
  Rat   381 PQILESSDADEPPGTLLSSV--------------NEQEIPARIQLCHDSPENSRLQDILLSASHS 431

  Fly   374 -DIP----SSGSNMVMLSTTSLLHGNC--VFNRNNTVATQQGMKTYWLCKSYRISMCRARCITHL 431
             |.|    ..||:.::......|:.:|  .:..:.|:.:|.       |::.:..:..|...:.|
  Rat   432 PDHPVVKSEFGSSPMLTGKEPELNIDCREPYTFDTTLLSQP-------CEAEQYRITSAAATSEL 489

  Fly   432 GRIISATGVHNHTPHMRGGQGSSAP----STASVSGNPAPTPISSQAGYSLTDGGGHLGPDLQHG 492
            ..|:.         .|..|.....|    .:....|...|:...|:.|.:..:|.....||::..
  Rat   490 EEILD---------FMLCGSDVEPPVGSLESPGAEGCRTPSYHLSETGKNWIEGEEWCLPDMELW 545

  Fly   493 NR-VTNMF---ANQTPPPPPPPPPLPVASTPHHPHHHHHLGQPLPNLLVQHHPAPSHMEQHGS-- 551
            .| :|.:.   ..:...|..|..||.:.|      .:....:||..|::....:...:...||
  Rat   546 PRDLTGLEKEPVGENKEPVEPFSPLVMRS------ENTESIEPLSPLVMPSEVSREELSLRGSWT 604

  Fly   552 ------SASLL--HNPNLMHLQTPTHHHQQQHHQQHSPHNPPPPQQHNLELGGGSGSGAVLLSPA 608
                  |:..|  ....|:||.:     .....:.:|..:||.|...:..|....|...| |.|.
  Rat   605 PDLEITSSQPLDGQGEKLIHLDS-----SDPSQRSYSDLSPPCPNWADTGLEVSLGMDEV-LCPV 663

  Fly   609 HLQQSPQSNRS-SHSLQAQSPPPQSVEEQQ 637
                 |::.|. |.:.:...|.|.|.|:::
  Rat   664 -----PKAVREVSANPELLDPFPGSSEDEE 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34376	NP_732741.1	BTB	20..113	CDD:279045	24/135 (18%)
		BTB	31..115	CDD:197585	24/133 (18%)
		FLYWCH	390..443	CDD:282369	8/54 (15%)
Btbd18	XP_002729248.1	BTB	24..123	CDD:279045	21/91 (23%)
Btbd18	XP_002729248.1	BTB	35..123	CDD:197585	20/87 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910