DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34376 and Btbd18

DIOPT Version :9

Sequence 1:	NP_732741.1	Gene:	CG34376 / 42638	FlyBaseID:	FBgn0085405	Length:	681	Species:	Drosophila melanogaster
Sequence 2:	NP_001138572.1	Gene:	Btbd18 / 100270744	MGIID:	3650217	Length:	723	Species:	Mus musculus

Alignment Length:	766	Identity:	141/766 - (18%)
Similarity:	242/766 - (31%)	Gaps:	243/766 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 GDLVDVTLACDGKLLHAHKIVLAICSPYFQE-IFTTNPCKHPIIILK--DVSFNIMMELLEFMYQ 88
            |...|..|..:|:.:.||..:|:.|||:|.| :....|.:...::|:  .:....:.:|::|:|.
Mouse    31 GVFCDALLQAEGEAVPAHCCILSACSPFFTERLERERPVQGRKVVLEMGGLKIQTLRKLVDFLYT 95

  Fly    89 GVVNVKHTELQSFMKIGQLLQIKGLAT-----------------NSN------SSPGSS--VSEK 128
            ..:.|...|.|..:...:.|::..|.|                 |..      ::|.|:  |..|
Mouse    96 SEMEVSQEEAQDVLSAARQLRVSELETLQLEGGKLVKAPQGRRLNRECLQPPAAAPISARVVGPK 160

  Fly   129 SSSQPP------------------AEESSNTNSTNHHNSSTNSNNNSKSETD---HNESKGQSNS 172
            |..|.|                  .||......||..|:.:.|:...|.:..   ..||:...:|
Mouse   161 SRPQTPLPVTQTPSPLGAVRLKSLGEEEGAHKKTNLPNADSLSDTQLKKKARVCLTQESRSSPSS 225

  Fly   173 R-------TTSPGGAS-------------------RASNDASHLYTSNKRPMPSDF--GSDSLSI 209
            :       .::||..:                   ..|..:.|:|||.    ||..  |..|:..
Mouse   226 QREGPKETKSNPGPTALPSLYPSVDEQLLPRKIRLSRSKPSPHVYTST----PSSILSGPSSMPT 286

  Fly   210 YSGKQL--RRSLKDHGSGGSEGGGG---------DHADTAAGLDNSMNSEEFFLPPIPQITMGEQ 263
            ..|::|  :|::.....|..:...|         |.:|.....:|...|.|...|....:..|:
Mouse   287 APGRRLWRQRTVSKEAQGVDKQKPGEVRPLQSTPDPSDVGKPAENKKQSPELRAPTSSSVEEGQ- 350

  Fly   264 RYDLGGLKRESDGHHHGPLSAGGGNSGSVGSLTSSASPSAPIRNPFAPNFMDSFNYYKGGNSSGP 328
               :|.:|...                .|...........|:||.     .||....:..:...|
Mouse   351 ---VGRVKLRK----------------IVNGTCWEVVQEPPLRNT-----QDSPQILEPSDVEEP 391

  Fly   329 SGSSNNSVGPGGVNNNGSVGLGSGAEYPNELYMPNDYSKS--------FANHM-DIP----SSGS 380
            ||:..:||              :..|.|..:.:..|..:|        .|:|. |.|    ..||
Mouse   392 SGTLLSSV--------------NEQEIPARIQLCQDSPESPRLQDILLSASHSPDHPMVKSEFGS 442

  Fly   381 NMVMLSTTSLLHGNC--VFNRNNTVATQQGMKTYWLCKSYRISMCRARCITHLGRIISATGVHNH 443
            :.::....|.|:.:|  .:..:.|:..|.       |::.:..:..|...:.|..|..
Mouse   443 SPMLTGKESDLNIDCREPYTFDTTLLGQP-------CEAEQYRITSAAATSELEEIFD------- 493

  Fly   444 TPHMRGGQGSSAP----STASVSGNPAPTPISSQAGYSLTDGGGHLGPDLQHGNR-VTNMF---A 500
              .|..|.....|    .:....|...|:...|:.|.:..:|.....||::...| :|.:.   .
Mouse   494 --FMLCGSDVEPPVGSLESPGAEGCRTPSYHLSETGKNWIEGEEWCLPDMELWPRDLTGLEKEPV 556

  Fly   501 NQTPPPPPPPPPLPVASTPHHPHHHHHLGQPLPNLLVQHHPAPSHMEQHGSSASLLHNPNLMHLQ 565
            ::...|..|..||.:.|      .:....:||..|::....:...:...||             .
Mouse   557 SENKEPVEPFSPLVMRS------ENTESFEPLSPLVMPSEVSREELSLRGS-------------W 602

  Fly   566 TPTHHHQQQHHQQHSPHNPPPPQQHNLELGGG---SGSGAVLLSPAHLQQSPQSNRSSHSLQAQS 627
            ||                       :||:...   .|.|..||   |...|..|.||.:.|   |
Mouse   603 TP-----------------------DLEITSSQPLDGQGEKLL---HFDSSDPSQRSYNHL---S 638

  Fly   628 PP----------------------PQSVEEQQPHQQQQQQQEGATTEVTTD 656
            ||                      |::|.|...:.:|.....|::.:...|
Mouse   639 PPCSDWAETGLEVSLGMDDVLCPVPKAVREVSANPEQLDPLPGSSEDEEID 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34376	NP_732741.1	BTB	20..113	CDD:279045	21/88 (24%)
		BTB	31..115	CDD:197585	21/86 (24%)
		FLYWCH	390..443	CDD:282369	8/54 (15%)
Btbd18	NP_001138572.1	BTB_POZ_BTBD18	20..138	CDD:349602	23/106 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..176		7/25 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	188..350		30/165 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	370..394		7/28 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	603..637		13/59 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	699..723
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000141
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910