DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG12499 and URB1

DIOPT Version :9

Sequence 1:NP_651044.1 Gene:CG12499 / 42637 FlyBaseID:FBgn0038968 Length:2059 Species:Drosophila melanogaster
Sequence 2:NP_055640.2 Gene:URB1 / 9875 HGNCID:17344 Length:2271 Species:Homo sapiens


Alignment Length:1995 Identity:427/1995 - (21%)
Similarity:725/1995 - (36%) Gaps:536/1995 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   215 VLENQMKSM-----QLGHR--RNALKLLTAIVCVEPQLARQVLNSYDVLSNVTVTQKLLSHEKSE 272
            ::.|.||.:     ..|:|  |..|.|:||:|...|:.||.|.:.:|:......|.......|..
Human   127 LMNNHMKLICESLYASGYRLARACLSLMTAMVTQGPEAARDVCSHFDLNKKTLYTLVTKRDSKGV 191

  Fly   273 YQCEDTVRKAFILFILAFLVEGNTLLIRNILDRGQLIG-VLAKGLVYDDHVTVCVVLNALRQYVL 336
            |.    ||:|::.|.|:||:.|:...|..:|:..:.|. :.:.|:..|...|:.::|:.|:..|:
Human   192 YD----VRQAYVQFALSFLIAGDDSTIVQVLEVKEFIPCIFSSGIKEDRISTINILLSTLKTKVV 252

  Fly   337 ENPEIQKTKKVLVFDLECCKNLRRLYDWEG-----PMGLKVMFAKSKHVSKIPPNPQEA--EAVS 394
            .|..|.||:||..|..:...::..||:|.|     |..:||             :.:||  ..|.
Human   253 HNKNITKTQKVRFFTGQLLNHIASLYNWNGITDVNPENVKV-------------SAEEAGKTMVR 304

  Fly   395 AAVHELLLVLLTSRKHGICF-DAM--THYRQKQNKLQGRLLGSLFKPYDNPRKVDLVIQTLTACP 456
            ..||..|:.|..|.||||.| ||.  |..|.....|...||| |....|:....|||:..|..||
Human   305 ELVHNFLMDLCCSLKHGINFYDASLGTFGRGGNLTLLHFLLG-LKTAADDDLVADLVVNILKVCP 368

  Fly   457 DL---------------GRNTVRNCSSLLSPV-KTKPKDLPIAVAF-----------LAQIINAV 494
            ||               .::|..|...||:.: :.:|:   |:.||           ||.::...
Human   369 DLLNKYFKEVTFSFIPRAKSTWLNNIKLLNKIYEAQPE---ISRAFQTREFIPLPRLLAMVMVTT 430

  Fly   495 PPSALSAAFDKMTLTDFSFWIKELCLPIEALLHITGKKYLSDPDFNLRLAVLRLLLSMMKQYSNY 559
            .|...:.:.....|...|..::...|   :|:.:..|:.|...|..|...|.        |.|..
Human   431 VPLVCNKSMFTQALNLDSTSVRHTAL---SLISVILKRALKTVDHCLNKEVW--------QESGV 484

  Fly   560 MNAIAVREQSKKAGNSLRKFKFDLLNHLLVHFPTIESILYSLYMFIK-----------QKNVEG- 612
            ..|:.:.|..:....:|.|.           .|.:.:::: ::..:|           ||..:| 
Human   485 YTAVMMEEFVQLFREALSKI-----------LPDLNTVVW-VWQSLKKQETKQDDKKGQKRSDGP 537

  Fly   613 --------VNVLESLSITLDLVMLLCKENRAFVNKTSQILDYLDVLRPLYETDFDKLNQ------ 663
                    .:..|::.:...|:.::|...:...:...|           |..||.||.:      
Human   538 PAACDAHQCDDAETILLKAVLLQVICLYQKVVPHVVMQ-----------YNFDFSKLLKGVISEQ 591

  Fly   664 ----------PEELLKIQLELKSIKTILLLFPHSLNPTQPLFG---NVFKSFIKAYMLEEK-SIK 714
                      ...:||:.|||.:.|.:.|....  .|...:.|   :||...:|.::.... .:|
Human   592 GLREEVPPILQHHMLKVALELPASKFLWLKAQE--GPDAEIIGGERSVFYLLMKMFVTSSHLQLK 654

  Fly   715 SESGNILSRLFQNTGMFDSCRHEINIWIEAL---IGFGPATVTNVVE-ILLTILCLDWR------ 769
            |.:..::.::.::||:|:....|:.:|:|.|   :.....||...:| ||||::...:.      
Human   655 SLTKLLIMKILRDTGVFEHTWKELELWLEHLENTMEEDKETVIQFLERILLTLVANPYSYTDKAS 719

  Fly   770 ---------QIELPEQSVTDTAIITKNLSKLFAQI------------EQGQTVQAYVETLT--LS 811
                     |..:.:|...|.:|...::..:...:            |.|.|:...:..||  .|
Human   720 DFVQEASMLQATMTKQEADDMSIPISHIDDVLDMVDVLVEGSEGLDEEIGFTLSEDMILLTFPFS 784

  Fly   812 KMMP---------LLLKGVELEEPYDEYVELVFVLLFHYHSKPE---IVLQMYE----------- 853
            .::|         ||..|.|..|....|:..|...|.|....|.   ::||.|:           
Human   785 AVVPAALEARNKLLLGTGNEAAENVVTYLTAVLTDLLHTQRDPLALCLLLQAYDKLEPPCLVPCC 849

  Fly   854 DNLSKHTNYMKSWLP----------GEGNGKPKKLP---------HLIFDKWPLLKQMRKVSTES 899
            ..||:...|...|:|          .:|:..|..||         ...::...|..:..:|..::
Human   850 QQLSRFNRYYSLWIPEQAREAWLLQAQGSPSPPALPLASSFTALLQAAYESQALRDEHIQVQLQA 914

  Fly   900 --ENMSFEQV--------FKMDDTENNFELQLEEGQTMLLHSSLGNP---------RRNMIYVQD 945
              .::|.:||        ..:..|..||      ||   |..|:|.|         ||.:::.:.
Human   915 TMPHLSMQQVLLAAKQVLLYLRSTVENF------GQ---LGRSVGPPLLQLFLDLLRRLVVHCEQ 970

  Fly   946 LLFVFSHFFTSQKLSKPQAELTADFLIKFLQIASQVDGPEEVQESDDEQQDENFTQSMLHYIFNH 1010
            |     .....|:....:||  ||..:....:||       ::.::|:..:|     :|..|..|
Human   971 L-----DAQNQQRCEAARAE--ADLFLDMESVAS-------LELANDQTLEE-----VLVAILRH 1016

  Fly  1011 RL---W------QLHPTELLSET---------SESRLNYVIFLRRLMEHCRSLPRFETYTANYRL 1057
            ..   |      |..|...||..         |...|..:.....::::...|.....|:.....
Human  1017 PTLEGWFLALEQQALPPHTLSPVLVKLLATHFSAGVLQLLAASAPILQNIGQLGLLARYSEAITQ 1081

  Fly  1058 HLIKTLDIALDTPV-------DQLGNQQQLDECVKLVDSFEFNSDQCSQMLDLLTTKVQAKDCIP 1115
            .::|.|......|.       .||...|:|...::.....|......|.....|.|:...|.   
Human  1082 SVLKELQNRRAGPATSPPKTPPQLEALQELHPYMEGAQLREVTLALLSLPETHLVTQQPTKS--- 1143

  Fly  1116 NGKPNHYFDLLLRLLGRLNTLKEPIDCGKSFKLILTFYKDFGELNEQQLEPFEL----------- 1169
            .||..|     |..||:  ||.:.:.|..                :.||:..||           
Human  1144 PGKERH-----LNALGK--TLVQLLTCSP----------------QDQLQSGELLWSSEYVRGLG 1185

  Fly  1170 AVLEFLLNYHHHMDECDSEFFACFFTSSR------------------KLSKSAIRLACLLLERQP 1216
            |:|..|.     :||.|:   ....|..|                  :.:::|:.:|.|||:   
Human  1186 ALLPTLA-----VDELDT---VLLHTLQRDPVLAPAVGADLLDYCLARRTQAALSIAALLLQ--- 1239

  Fly  1217 RLAETFAELL----------PSNLEQKDL--VYPLLDIAL---TKNY--------QIPLPVLQRC 1258
               |:...||          |....|.||  ..||:.:.|   |:::        ...:|||::.
Human  1240 ---ESCTHLLWFEQWCLQAGPGLGLQGDLDDFLPLIHVYLQCRTRSHFTRPAGVSSAVIPVLRKT 1301

  Fly  1259 YQTYKNGFMKSIEKPQKAALIYREHSEASALLIALCMPKSECFDYCQKQLKLDSVELFQVRVLRE 1323
            ........:.|.:.|..:.| |:|       ::|..:|                           
Human  1302 LWRQLQSRLLSTDSPPASGL-YQE-------ILAQLVP--------------------------- 1331

  Fly  1324 IYWQGFAAAKDEKQKATVFVNYI-------NLNVQLLALDLKKQALDLPKLEQISW------NCY 1375
                 ||.|||    .:|.::.:       :.:.:.:..|....||:....|..:|      :|.
Human  1332 -----FARAKD----LSVLMDRLPSLLHTPSSHKRWIVADSISAALEGSAEELCAWRRTLLESCV 1387

  Fly  1376 EWW-------------KTNRTDDLPLDWSRL-----QKNP-QWLNFCKSSLKLALHLGEERLPLQ 1421
            :|.             ..|:..::.|..:.|     :.:| .|..|.|..||..         .|
Human  1388 KWLIVSFSGGQQDDDNTQNQEKEMLLRLNALLHALNEVDPGDWQKFVKKGLKFR---------YQ 1443

  Fly  1422 DETNGLVLKLMAFLCDGMYDEYKEDAQQEEDATPTLLYEMICTHSCCFDHLL------GKPSETK 1480
            |.|   .||::......:|.  .|.:.:.:.....::|.|:..||.....||      ...|:.|
Human  1444 DHT---FLKMLLTAVQLLYS--PESSVRTKLIQLPVVYVMLMQHSLFLPTLLTSDGEESPDSQVK 1503

  Fly  1481 THILHLMEVLARKAPSALQSDHIPVILGSYHAKLSPADRYGLALLEHYERFDVGLDKFRPFIWGE 1545
            ..::.||..:....||..:|.|..|:||:|.|.||..|:..|.||..||:..:.|..||..:||.
Human  1504 EALVDLMLTVVEMCPSVCESSHFAVLLGAYGATLSVLDQKILLLLRAYEQNKLSLINFRVLLWGP 1568

  Fly  1546 SAVAHYALRAADEDVRT--RLQQQETNVAQVLALIVRETSEYTIENFPIWRSLHASQQLPSTEFQ 1608
            :||.|:      :..|:  |...|:.:|..:|.|:.|:....||.:||..|.|     ||     
Human  1569 AAVEHH------KTCRSLGRSLWQQPSVGDILRLLDRDRMMQTILHFPQNRRL-----LP----- 1617

  Fly  1609 NPAKKSMSFGDNQLEQMVEQGQLDFPQDLRRIC--PKRETIYETCYDPAFLLPLMMHCFAPESVV 1671
                                     |:|.:.:.  .|.....:..|||.|||.|......||.||
Human  1618 -------------------------PEDTQELIFKDKSRVDLDGLYDPCFLLQLFSELTRPEFVV 1657

  Fly  1672 WARWPVQNGLLAITFCGLSSLDKDMRLAAASCQQRYRAHFELSNFYERPLWTQAYENIQAGLADL 1736
            ..|..:.:..|.:|...|||.|..||..|......|.:|.|.:.|.|:.......:.::.|:   
Human  1658 DCRKFLDSNALGLTVTALSSYDPQMRAIAYHVLAAYYSHLEGARFQEQSQLLYLLDVVRNGI--- 1719

  Fly  1737 RNSWLAQRRTHGGTPRVPLIPGLFIAHSFNLSTEPTHLLYKRLMMYLRLKQSFNFQTIPDFNVFF 1801
                    ||.  ..|:.....||||.:.....:|...:|.::..:|...:..|...:|.|..||
Human  1720 --------RTQ--DMRLTFTLALFIAKAALQILKPEEHMYLKVSNFLLSHEYLNMDKVPGFYQFF 1774

  Fly  1802 YSQEPEHQQYREFIVELLRCGIKCSADLFLLVSTNTFKVLLGFYGSSLASLETNLLLLSVLSTCV 1866
            ||.:.|.:..::::..:||.||:......|......|.::|.|:.|.|........:|.:|....
Human  1775 YSSDFEQKTEQKWVFGVLRQGIRDKQCYELCARRGIFHIILSFFHSPLCDEAAQNWILEILQNAA 1839

  Fly  1867 KIPGAVKIMLEHVGILSWLVGVIRDTEFHQFDIIEGVISILNNLW 1911
            ::..:...::....:|:|::.:: :::|.:..::..|||:|:.||
Human  1840 QVARSAYEIIRDYSLLTWILHIL-ESKFLETPLLSNVISLLHTLW 1883

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG12499NP_651044.1 Npa1 160..475 CDD:288544 85/293 (29%)
NopRA1 1682..1884 CDD:292818 46/201 (23%)
URB1NP_055640.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..43
Npa1 78..393 CDD:288544 82/283 (29%)
NopRA1 1668..1857 CDD:292818 46/201 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2021..2042
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165154134
Domainoid 1 1.000 104 1.000 Domainoid score I6722
eggNOG 1 0.900 - - E1_KOG1791
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 230 1.000 Inparanoid score I3450
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG47560
OrthoDB 1 1.010 - - D352351at33208
OrthoFinder 1 1.000 - - FOG0006129
OrthoInspector 1 1.000 - - oto90120
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR13500
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1908
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.990

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