DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12499 and AT1G72270

DIOPT Version :9

Sequence 1:	NP_651044.1	Gene:	CG12499 / 42637	FlyBaseID:	FBgn0038968	Length:	2059	Species:	Drosophila melanogaster
Sequence 2:	NP_565039.5	Gene:	AT1G72270 / 843559	AraportID:	AT1G72270	Length:	2401	Species:	Arabidopsis thaliana

Alignment Length:	2493	Identity:	487/2493 - (19%)
Similarity:	826/2493 - (33%)	Gaps:	852/2493 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 MHFRTKLRGNNFITELRHFLH--------MCSTTR------------PKLAAKYIEKRGKPLELA 162
            |.||..|.     .:||..||        :||.|.            ..|...|.:......||.
plant     1 MAFRPSLE-----AKLRQLLHNICLHEFKLCSDTAKDFVKLLKGETGSDLLRLYFQSSPNFTELL 60

  Fly   163 EAFERIDKTNLFH----VDYLTEALHRVLMEILTNQKSHME--SAVHG------CRYFLKVHGGV 215
            ||:      ||.|    :.|:...:..:|        ||.|  |:..|      ||  |.:...:
plant    61 EAW------NLHHGKQGLSYIFSLIQTIL--------SHPEGKSSDIGRALDQFCR--LLIEKKL 109

  Fly   216 LE-----NQMKSMQLGHRRNALKLLTAIVCVEPQLARQVLNSYDVLSNVTVTQKLLSHEKSEYQC 275
            |:     :..|.:|    ..||.||.:||...|.:|.::..::|.            |...
plant   110 LDIYKALSNTKRLQ----NAALSLLASIVRRGPGMASEMARTFDF------------HGFP---- 154

  Fly   276 EDTVRKAFILFILAFLVEGNTLLIRNILDRGQLIGVLAKGLVYDDHVTVCVVLNALRQYVLENPE 340
            :...|:||:.|.::||..|...|:::||::.||...|.:||..||..|:..||:.|:.
plant   155 KQAPRRAFVEFAISFLQVGKPSLLKSILEKKQLYSQLLQGLEEDDDDTLASVLSTLKD------- 212

  Fly   341 IQKTKKVLVFDLECCKNLRRLYDWEGPMGLKVMFAKSKHVSKIPPNPQEAEAVSAAVHELLLVLL 405
                 |:||  .|...:.|.:....||..|:.:...|:.        ::...|:...:::|:.:.
plant   213 -----KILV--QESSLSPRLMSALFGPKTLEQLVIISER--------EDGGIVNELAYDVLVKVC 262

  Fly   406 TSRKHGICFDAMTHYRQKQNKLQGRLLGSLFKPYDNPRKVDLVIQTLTACPDLGRNTVRNCSSLL 470
            |...:|:..||   ||:...|   ||| :|.|                              ||.
plant   263 TDPSNGLMPDA---YRKGNIK---RLL-ALMK------------------------------SLK 290

  Fly   471 SPVKTKPKDLPIAVAFLAQIINAVPPSALSAAFDKM--TLTDFS--FWIKELCLPIEAL--LHIT 529
            :.....|:||.:|      ||.. .||..||.||:.  .:.||:  :|...:.|..:.:  :.::
plant   291 ATETGYPRDLLLA------IIRG-RPSLASAFFDEFPYNVEDFTSPYWFSSISLAADLVSSVRMS 348

  Fly   530 GKKYLSDPD----------------------------------FNLRLAVLRLLLSMMKQYSNYM 560
            ......:||                                  |.::...||.|...::.:.:::
plant   349 SSFDFLNPDKPPSGGSEVHTIMKCICPRPFSQSLIARGMHHSVFLVKHGTLRFLWETLRLWDSFV 413

  Fly   561 NA--IAVREQSKKAGNSLRKFKFDLLNHLLVHFPTIESILYSLY-----MFIKQK---------- 608
            .|  :...:|.:.   ||.:   |::..::..||..: :|:::.     :.:|:|
plant   414 TAWKLCSVDQIQA---SLER---DIIGEVISFFPDFQ-VLWTVLKVSQKLSLKRKAELDIGLVDR 471

  Fly   609 ----NVEGVNVLESLSITLDLVM-LLCKENRAFVNK---TSQILD-------YLDVLRPLYETDF 658
                ....:.|||.|:  .|:|: .|..:...|:.:   .:|:.|       ||.::..::.::|
plant   472 KKRLKTSEMAVLEELA--SDMVIGGLGSDTNIFLEEDTGDAQLTDQEDAENEYLGIVSEIWGSEF 534

  Fly   659 -----DKLNQPEELLKIQLELKSIKTILLLFPHSLNPTQPLFGNVFKSFIKAYMLEEKSIKSESG 718
                 ..:::.|...:|:|    :.|:.:......|..:.|| :||..|     |...|| :..|
plant   535 CSKPIASVDEAEMFFQIKL----LDTLGIYVRSVPNVPKGLF-DVFMKF-----LSSSSI-TAVG 588

  Fly   719 NILSRLFQNTGMFDSC---RHEINIWIEALIGFGPATVTNVVEILLTILCLDWRQIELPEQSVTD 780
            |.|         |..|   |..::......|||.|           .|:|:..:.::|.......
plant   589 NTL---------FQQCAIVRSSLSHLKGVSIGFSP-----------LIVCILQKCVKLLNSESQA 633

  Fly   781 TAIITKNLSKLFAQIEQGQTVQAYVETLTLSKMMPLLLKGV--ELEEPYDEYVELVFVLLFHYHS 843
            .::..|:...|:........:|..|:...||.::..:|..|  ..::...|::.|..:|||....
plant   634 YSLPNKSAVSLYVYSSLKYILQTQVDPRPLSCLVQSVLSEVVDGSKDSLCEWLPLRVLLLFTQSL 698

  Fly   844 KPEIVLQ-----------MYEDNLSKHTNYMKSWLPGEGNGKPKKLPHLIFDKWP--LLKQMRKV 895
            ....:|.           .:...|.:....|:|..|.|..|........:....|  :||....|
plant   699 SEPFILHSGRTTCRLADTSFAATLDEIKGLMRSITPDEVGGVVNAFSSALICATPESILKNFASV 763

  Fly   896 STESENM---SFEQVFKMDDTENNF----------------EL----QLEEGQT-----MLLHSS 932
            ...|.::   ||..:..:...|.||                ||    .|.||..     ...|||
plant   764 MAVSWDLYGTSFSFLLSIIFLEKNFLGNLSKLSPDLFMRGLELTVSRNLREGTVDSEIDFADHSS 828

  Fly   933 LGNPRRNMIYVQDLLFVFSHFFTSQ------------------------------KLSKPQAE-L 966
            .....::.:.:.|:..:....|..|                              |:|:|::: :
plant   829 TTEKIKSKMDIPDIESLAFSVFLEQTPFPVLLNEIMSMDISCLPEFPRLTELLLLKVSQPKSDSI 893

  Fly   967 TADF-LIKF--LQIASQVDGPEEVQESDDEQQDENFTQSMLHYIFNHRLWQLHPTELLSETSESR 1028
            .:|. ||.|  .||.|..    :||......|.......::.::|:    |:...:|:|..|..:
plant   894 ESDIRLILFWLFQIRSLY----KVQPHPVLCQQSEICLRLMRHLFS----QISKLDLVSGPSADK 950

  Fly  1029 LNYVI--------FLRRLME---HCRSLPRFETYTANYRLHLIKTLDIALDT--PVDQLG----N 1076
            |.:.:        .:..|:|   .|.:|||            ::.:::..:|  ...:||    :
plant   951 LKHQVPQTVLSHPVVMALLESPADCDTLPR------------VQNVEVFSETLLTAGRLGISEID 1003

  Fly  1077 QQQLDECVKLVDSFEFNSDQCSQMLDLLTTK-VQA------------KD----CIPNGKPNHYFD 1124
            |..||......::|.|......:..||...| :.|            :|    |:.:   ..|..
plant  1004 QHILDLLASTCENFLFEESHIERKGDLRADKSIMAFKVLVERLLLVFRDKFELCVGS---QSYAP 1065

  Fly  1125 LLL--RLLGRLNTLKEPIDCGKSFKLILTFYKDFGELNEQQLE-------------PFELAVL-- 1172
            ||.  :|:..|.....|      |||:...:....:..|::|.             .||:.:|
plant  1066 LLQHPQLIQALLKFISP------FKLLYLAHSMLSKTYEEELASPILSFGLDIAGGAFEMLILYS 1124

  Fly  1173 ----------EFL-----LNYHHHMDECDSEFFACFFTSS------------------------- 1197
                      :||     .||...:.| .....||.|::|
plant  1125 RQPAAKRRVYDFLWELEDKNYDSRIIE-QVYSLACRFSTSFGLASADTCLLKVVSGIFRGGNSQH 1188

  Fly  1198 --------------------------RKLSKSAIRLACLLLERQPRLAETFAELLPSNLEQKDLV 1236
                                      .:.|.|..::...|:|..|.....|..:..|.|.:..
plant  1189 CSVHQLTVIMSQIVGRTSKDLIIHCINQASMSRAKILFYLVESSPLHLSVFGHIFFSMLSKLQ-- 1251

  Fly  1237 YPLLDIALTKNYQIPL---PVL--------------QRCY---QTYKNGFMKSI----------- 1270
               .|.||..:.|..:   |||              .:|.   ..|.|..:|..
plant  1252 ---GDSALITDDQFVMLLPPVLLFLASVFAKLEKSCSKCLDITSLYSNILIKGFLQWPKFCSGCI 1313

  Fly  1271 --EKPQKAALIYREHSE----ASALLIALCMPKSECFDY----CQKQLKLDSVELFQVRVLREIY 1325
              ||.::..|...|..|    ||.|..|:.|     |.|    .:...|.|.        |.:::
plant  1314 FEEKYEEILLSTSEDIETMFNASLLGKAVRM-----FQYHFALTESPTKTDD--------LLKVF 1365

  Fly  1326 WQGF---AAAK----------DEKQKATVF--VNYINLNVQLLAL----------DLKKQA---- 1361
            :..|   :|.|          |.|....:|  .|.:...|:|..:          .||:||
plant  1366 YSMFPHTSAGKEMLDYEIKEVDVKSVDQMFNITNRLVAKVELSRICLFPEDSCMHHLKRQAGGCV 1430

  Fly  1362 -------------LDLPKLEQI--SWNCYEWWKTNRTDDLPLDWSRLQKNPQWLNFCK------- 1404
                         |..|.|...  :|.|.    ..|:|......|..::..::...||
plant  1431 KESSPEMGSNRESLLNPLLNAFVNTWQCV----VERSDGYYKGNSEREEQDKYWFLCKSLEYFIL 1491

  Fly  1405 -SSLKLALHLGEE-----RLPLQDETNGLVLK--------------LMAFLCDGMYDEYKEDAQQ 1449
             |.||....:.||     .||..:....|:|:              :.:||..|.|..:.:|...
plant  1492 RSILKFLEGMCEELAHLDSLPFLERLMNLILRYRFKDSKTLKILREIFSFLSRGKYSYHFQDLVS 1556

  Fly  1450 EEDATPTLLYEMICTHSCCFDHLLGKPSETKTHILHLM----------EVLARKAPS-ALQSDHI 1503
            ....|     |.|.:.|....| .|:.....:.||.|:          |..:.:||. .|....|
plant  1557 HSQFT-----ESISSLSISSSH-TGEVIRPVSSILKLLIIPNLNSVRVENCSLEAPEYYLSQIEI 1615

  Fly  1504 PVILG-----------------------SYHAKLSPADRYGLALLEHYERFDVG---LDKFRPFI 1542
            ..|||                       ||.|..|..|.....|: |..:..||   |:....::
plant  1616 LKILGVLLCKCGKDSGIFLKDLHFRLLCSYGATPSEIDLQSYKLM-HDIKLIVGEHTLNDSEDYL 1679

  Fly  1543 WGESAVAHYALRAAD-------EDVRTRLQQQETNVAQVLALIVRETSEYTIENFPIWRSLHASQ 1600
            ||.:|:.......:|       ||:|..|.::.      |.|..:..:: |:..||..|:..||.
plant  1680 WGNAALKIREGLPSDGSYSDIVEDLRQSLFKEN------LCLDPKRCAQ-TVLYFPYGRTAEASD 1737

  Fly  1601 QL-----PSTEFQNPAKKSMSFGDNQLEQMVEQGQLDFPQDLRRICPKRETIYETCYDPAFLLPL 1660
            ..     |.:|..:||              :|:                       |||.|:|.:
plant  1738 NTYIYDDPISEKCSPA--------------IER-----------------------YDPVFILRV 1765

  Fly  1661 MMHCFAPESVVWARWPVQ---NGLLAITFCGLSSLDKDMRL-----------AAASCQQRYRAHF 1711
            .:...   |:|:.. ||:   .||||:.|..:||.|..:|.           ...||  |...|.
plant  1766 SVQLL---SMVYIE-PVEFASLGLLAVAFASMSSADLGIRKLGYETLGIFVDVLESC--RKNMHV 1824

  Fly  1712 ELSNFYERPLWTQAYENIQAGLADLRNSWLAQRRTHGGTPRVPLIPGLFIAHSFNLSTEPTHLLY 1776
            .:.    |.|.|.    :|.|:.:   .|          .|:|.:..:|.|.:..:..:.:|..|
plant  1825 TVL----RLLLTY----VQNGVEE---QW----------QRIPTVSAVFSAEASLILLDSSHEHY 1868

  Fly  1777 KRLMMYLRLKQSFNFQTIPDFNVFFYSQEPEHQQYREFIVELLRCGIKCSADLFLLVSTNTFKVL 1841
            ..::..|:...:...:.||.|:.||.|.....:..|.:::.|:..|::...|..:.:..:..:.:
plant  1869 VPIIKLLKRSSTLKLRGIPLFHDFFGSSTVNFRSQRLWVLRLVFVGLESEEDAQIYIRNSILETV 1933

  Fly  1842 LGFYGSSLASLETNLLLLSVLSTCVKIPGAVKIMLEHVGILSW---------------------- 1884
            :||:.|.||..||..|:|.|:...||:....:.::|:.|:|||
plant  1934 MGFFSSPLADDETKGLILQVVRKSVKLHKMARHLVENCGLLSWCSSFFSMLTTKPTGDEDSRFVV 1998

  Fly  1885 LVGVI-------RDTEFHQFDIIEGVISILNNLW-------------------YALAASRSELTD 1923
            ::.||       .|||:.|...:||::.|.:.|:                   ..|..|.....:
plant  1999 VLEVITDALASRNDTEWSQRSALEGLMEISSRLYTLLGDGLVSMQENGTSILSATLKISHKRKKN 2063

  Fly  1924 YDHIQLRVYRLVLQLLPLL----SPRISVPGLGRLFNVLWKTGSACGQHRAVSATQMDT------ 1978
            ..|..:.: ..:.||....    ||::.....|||..:|..|       ..|....||.
plant  2064 QPHFTITI-EGIFQLFEAAANCDSPQVEASAEGRLDTILMST-------PPVEIICMDVHRLRRF 2120

  Fly  1979 LLECVSRQWPDQLASVRYVRSFGSAGACSRSEYCDWLAKDQKLETPAVLALSSLR----EYVIDW 2039
            ||      |....|....::.....|.|.         :|.|..|...:....||    ..::..
plant  2121 LL------WGSSTALKSDLKKGSKPGECH---------QDTKTHTEETMVAKFLRWLLASVILGK 2170

  Fly  2040 AQAHKSESD----GETKLLVEPT 2058
            ..:..::||    .|||....||
plant  2171 LYSEANDSDQIVLSETKPETLPT 2193

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12499	NP_651044.1	Npa1	160..475	CDD:288544	76/331 (23%)
CG12499	NP_651044.1	NopRA1	1682..1884	CDD:292818	49/212 (23%)
AT1G72270	NP_565039.5	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	70	1.000	Domainoid score	I3404
eggNOG	1	0.900	-	-		E1_KOG1791
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D804299at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3385
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13500
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.010