DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12499 and EMB2788

DIOPT Version :9

Sequence 1:	NP_651044.1	Gene:	CG12499 / 42637	FlyBaseID:	FBgn0038968	Length:	2059	Species:	Drosophila melanogaster
Sequence 2:	NP_001320074.1	Gene:	EMB2788 / 828809	AraportID:	AT4G27010	Length:	2574	Species:	Arabidopsis thaliana

Alignment Length:	2638	Identity:	494/2638 - (18%)
Similarity:	843/2638 - (31%)	Gaps:	930/2638 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 MAEDEIS--RDSGI-------DPEESRIHFPNDFKMMHFR----TKLRGNNFITELRH--FLH-- 138
            |||...|  .|.|:       |.|..:|      .:|.||    .|||      ||.|  .||
plant     1 MAESISSDLEDQGMVVDGGNRDVEVGKI------PVMAFRPSHEAKLR------ELLHNICLHEI 53

  Fly   139 -MCS------------TTRPKLAAKYIEKRGKPLELAEAFE-RIDKTNLFHVDYLTEALHRVLME 189
             :||            .|...|...|.:......||.||:: |.:|..|   .|:...:..:|
plant    54 KLCSDAAKEFVKLLKGETGGDLLRLYFQSSPNFAELLEAWKLRHEKQGL---SYIFSLIQTIL-- 113

  Fly   190 ILTNQKSHMESAVHGC----------RYFLKVHGGVLENQMKSMQLGHRRNALKLLTAIVCVEPQ 244
                  ||.|......          |..::.....:..::.|.:...:..||.||.:||...|.
plant   114 ------SHPEGKDRSTDIGRAIDQFGRLLVEEKLDDIYKELNSKEGKQQSAALSLLASIVRRGPG 172

  Fly   245 LARQVLNSYDVLS-------NVTVTQKLLSHEKSEYQCEDTVRKAFILFILAFLVEGNTLLIRNI 302
            :|.::...:|...       |...|:|:..|         :.||||:.|.::||..|...|:.::
plant   173 MASEIAKKFDFKGFAKLAEYNTQGTEKVKKH---------STRKAFVGFAISFLEVGKPGLLSSV 228

  Fly   303 LDRGQLIGVLAKGLVYDDHVTVCVVLNALRQYVLENPEIQKTKKVLVFDLECCKNLRRLYDWEGP 367
            |::.::...:..||..||..||..||:.|:.            |:||.:......||
plant   229 LNKKEMYSKVLPGLGKDDDDTVASVLSTLKD------------KILVEESLISPGLR-------- 273

  Fly   368 MGLKVMF--AKSKHVSKIPPNPQEAEAVSAAVHELLLVLLTSRKHGICFDAMTHYRQKQNKLQGR 430
               .|:|  ...||::.|... ::|..|:...|::|:.:.|...:|:..||....|...::|...
plant   274 ---SVLFGIVTLKHLASISAR-EDAGIVNELAHDVLVKVCTDPSNGLMPDAKRKLRGNSDRLLML 334

  Fly   431 LLGSLFKPYDNPRKVDLVIQTLTACPDLGR-------------------NTVRNCSSLLSPVKTK 476
            :.|.........|  ||::..:...|.|..                   :::...::|:|.|:|.
plant   335 MKGLRAAEIGYHR--DLLLAIVRGRPSLASDFLDEFPYNVEDFSSPSWFSSISLAANLVSSVRTS 397

  Fly   477 PKDLPIAVAFLAQIINAVPPSALSAAFDKMTLTDFSFWIKELC-------LPIEALLHITGKKYL 534
                 .:..||.....|.|||..|   |..|:      :|.:|       |..:.:||
plant   398 -----CSFDFLNPDQRATPPSGGS---DVQTI------MKCICPRPFSRSLITKGMLH------- 441

  Fly   535 SDPDFNLRLAVLRLLLSMMKQYSNYMNAIAVREQSKKAGNSLR-KFKFDLLNHLLVHFPTIESIL 598
              .||.::...||.||..::...:::.|..:....:.:...:: ..:.:::..:...||..:.:|
plant   442 --SDFLVKHGTLRFLLETLRLLDSFLTAWNLCSSHRCSVEQIQISLERNVMGEVSSFFPDSQVLL 504

  Fly   599 YSLYMFIKQKNVEGVNVLESLSI----------------------------TLDLVM-------- 627
            ..|      |:::|.:..:.||:                            .:|:|:
plant   505 IVL------KSLDGSSGTQKLSLKREAELDSGLVGRKKRIKRSEKDVLEEEAVDIVIGGVGSDKD 563

  Fly   628 LLCKENRAFVNKTSQ---ILDYLDVLRPLYETD-----FDKLNQPEELLKIQLELKSIKTILLLF 684
            :...|:....:.|.|   ..:||.::..::.::     .|.:.:.|....|:| |.::|..:...
plant   564 IFLAEDNMDAHMTDQEDAEKEYLGIVSDIWISELCSNPIDSVEEAEMCFHIKL-LDALKIYVRAV 627

  Fly   685 PHSL-------------------------------------------NPTQ--PLFGNVFKSFIK 704
            |:.|                                           .||:  ||.....:.||.
plant   628 PNELEGSFDIFMKFLSNSFGMPVELQRALLSLLSEYISWTPKSQSDRGPTRIPPLMHKHLRVFIN 692

  Fly   705 AYMLE-EKSIKSESGNILSRLFQNTGMFDSCRHEINIWI----------------EALIGFGPAT 752
            ..:.. ...:|..:.|:......:||.|::...||..|.                ||:.......
plant   693 LLLFSPHNGVKDLAYNLAVAAMNSTGAFENNPSEIGAWFLFLPCFEKIKLPLELQEAVQSMSSVV 757

  Fly   753 VTNVVEILLT-----------------------------ILCLDWRQIELPEQSVTDTAIITKNL 788
            |:.:.:.:.|                             |:||..:.:.| ..|.:.|::..|:.
plant   758 VSFLCDAVSTVGNNLFKHWDIVRSSLSHLKGVSIGFSPLIICLLQKCVRL-LNSESKTSLPEKSA 821

  Fly   789 SKLFAQIEQGQTVQAYVETLTLSKMMPLLLKGVELEEPYD-------EYVELVFVLLFHY---HS 843
            ..|:.    ..|::..::|...||::..|::.| |.|..|       |:..|..:|.|..   :.
plant   822 ISLYV----CSTLKYLLQTQVDSKLLSCLIQSV-LSEVVDESKDSLCEWRPLRMLLCFSQSLSNE 881

  Fly   844 KPEIVL-----------QMYEDNLSKHTNYMKSWLPGEGNGKPKKLPHLIFDKWPLLKQMRKVST 897
            || |:|           ..:.:.|.:....::|..|.|..|..|.....:....|
plant   882 KP-IILHSRRTTGLPADSSFAETLDEIKRLVRSISPDEIAGIVKAFSSALICATP---------- 935

  Fly   898 ESENMSFEQVFKMDDTENNFELQLEEGQTMLLHSSLGNPRRNMIYVQDLLFVFSHFFTSQKLSKP 962
            ||...:|..|..:............:..|.|..:.|||..:   ...||....|.|..|..|
plant   936 ESILQNFASVMDVSWAFYGTPFSFLQSITFLEENFLGNLSK---LSPDLFASGSEFTGSGNL--- 994

  Fly   963 QAELTADFLIKFL-------QIASQVDG--------------------------------PE--- 985
             .|.|.|..|.|.       :|.|::|.                                ||
plant   995 -CEGTVDSEIDFSGHSSVTEEIRSKMDNRDMESSAFSIFLKQAPFPVLLNAIMSMDISCLPEFPR 1058

  Fly   986 -------EVQESDDEQQDENFTQSMLHYIFNHR-LWQLHPTELLSETSESRLNYVIFLRRLMEHC 1042
                   :|.:......|.|. |.:|.::|..| .:::.|..:|.:.||..|       |||::.
plant  1059 ISELLLLKVSQPKSGSIDSNI-QLILFWLFQIRSSYKVQPAPVLHQLSEICL-------RLMKNL 1115

  Fly  1043 RSL---------PRFETYTANYRLHLIKTLDIALDTPVDQLGNQQQLDECVKL--VDSFEFNSDQ 1096
            .|.         |......|::.....:..:..|..||.....:..|| |..|  |.:.|..|:.
plant  1116 FSQISEPELVSGPSSNKLPASFAKWKHQVAETVLCHPVVMALLESPLD-CGTLPPVQNVEIFSET 1179

  Fly  1097 CSQMLDLLTTKVQAKDCIPNGKPNHYFDLLLRLLGRL-------NTLKEPIDCGKSF-------- 1146
            ...|..|:.:::.          .|..:||:......       |..||.:...||.
plant  1180 SLTMGRLVFSEID----------QHILNLLVSTCEHFLFDEKPPNLWKEDLRKNKSIIAFKDLVE 1234

  Fly  1147 KLILTFYKDF-----GELNEQQLEPFEL--AVLEF-----LLNYHHHM-DECDSE---------- 1188
            :|:|.|...|     .:.....|:|.:|  |:|.|     |.|..|.| .:.|.|
plant  1235 RLLLEFRVKFELCVGSQSYVSLLQPAQLIHALLRFISPFKLFNIAHSMLSKIDEEGLTSPNSSII 1299

  Fly  1189 -------------------------------------------------FFACFFTSSRKLSKSA 1204
                                                             ..||.|::|..|..:.
plant  1300 LSLGLGIAGGAFEMLVLYSHQPTAKRGVYDLLWELEEKNYASNIIEKVYSMACKFSTSLDLDSAD 1364

  Fly  1205 IRL--AC----------------------LLLERQP---------RLAETFAELLPSNLEQKDL- 1235
            |.|  .|                      |::.|.|         |.:.|.|::|...:|...|
plant  1365 ICLLKVCGGIFRGKHNQNYAVDPLVLKISLIVGRTPEDLIIHCINRASITRAKILFYLVESSPLH 1429

  Fly  1236 -------VYPLL-----DIALTKNYQIPLPVLQRCYQTYKNGFMKSIEKPQKAAL---------- 1278
                   .:.:|     |.|||.:..|   :|.....:|....:..:|||....|
plant  1430 LLVFGHFFFSMLSKKQDDSALTDDQFI---MLLPAVLSYLTSVIAKLEKPCNRCLDITSVYSNIL 1491

  Fly  1279 --------------IYRE-HSE--------------ASAL------------------------- 1289
                          |:.| |.|              ||.:
plant  1492 INGFLQWPRFLARCIFEEKHEEILLSTTEDMETMFNASLIGKAVRMFQYHFSLTESPTKEDDLFK 1556

  Fly  1290 ----LIALCMPKSECFDYCQKQLKLDSVELF---QVRVLREIYWQGFAAAKDE------KQKATV 1341
                :..|.....|..||..|::.:.||:..   .:||:.::.........::      |:.|..
plant  1557 VFNSMFPLSSTGKEMLDYEIKEVDVQSVDQILNVAIRVVAKVTVSRICLFPEDSSMCHLKRAAGT 1621

  Fly  1342 FVNYINLNVQLLALDLKKQALDLPKLEQI--SWNC------------YEWWKTNRTDDLPLDWSR 1392
            .|...:..:     ...:..|..|.|:.:  ||.|            || .|.:|.      ||.
plant  1622 CVKESSSKI-----GCNRAILSKPLLDALVNSWQCVVKKSDGSFKGNYE-GKQDRC------WSL 1674

  Fly  1393 LQKNPQW-----LNFCKSSLKLALHLGEERLPLQD--------------ETNGLVLKLMAFLCDG 1438
            .:....:     |.|.:|..:..:.|  :.||..|              :|..::.::.:.|..|
plant  1675 CKSLENFILRSILQFLESMCEELVQL--DSLPFLDRLMKSVLLYRFEDSKTLKILREIFSLLSRG 1737

  Fly  1439 MYD--EYKEDAQQEEDATPTL------------LY---EMICTH------------SCCFDHLLG 1474
            .|.  .|.:........|||:            |:   ..|..|            .||    |.
plant  1738 KYSYAPYIQRLIYHSRFTPTISSLSISSSNTGELFRPVSSILNHLIILSPDSVRVKRCC----LE 1798

  Fly  1475 KPSETK-THILHLMEVLAR-----KAPSALQSDHIPVILGSYHAKLSPAD------RYGLALLEH 1527
            .|...| ..|:.::.||..     .....|.||...::|.||.|.|...|      .:.:.|:|.
plant  1799 APKYAKQLEIVKILRVLLSNCGKDSGMKELLSDLHFLLLCSYGATLREIDLEIYKLMHDIKLIEA 1863

  Fly  1528 YERFDVGLDKFRPFIWGESAVAHYALRAADEDVRTRLQQQETNVAQV-LALIVRE---------- 1581
            .:..:|   ....::||::|:          .:|..|.|..::|.|| |...||:
plant  1864 EQTLNV---SETDYLWGKAAL----------KIREGLSQDASDVCQVDLVEDVRQGLIKENLCVD 1915

  Fly  1582 --TSEYTIENFPIWRSLHASQQLPSTEFQNPAKKSMSFGDNQLEQMVEQGQLDFPQDLRRICPKR 1644
              ....|:..||               :|...:||.:|
plant  1916 PKICALTVLFFP---------------YQRTTEKSENF--------------------------- 1938

  Fly  1645 ETIYETCYDPAFLLPLMMHCFA------PESVVWARWPVQNGLLAITFCGLSSLDKDMRLAAASC 1703
             .:|:   ||...:|:....|.      .|.|.:|    ..||||:.|..:||.|..||......
plant  1939 -YLYD---DPINEVPVFSFNFQLIVLGYIEPVEFA----SLGLLAVAFVSMSSADLGMRKLGYET 1995

  Fly  1704 QQRYRAHFEL------SNFYERPLWTQAYENIQAGLADLRNS----------WLAQRRTHGGTPR 1752
            .|.:....|:      .|....|:.|:.:.....||.:.|.:          ...|........|
plant  1996 LQIFLDALEMGKDIVEGNILAFPICTEDFNWFCKGLMNCRKNKHVTGLRLLLMYVQNGVEEPWQR 2060

  Fly  1753 VPLIPGLFIAHSFNLSTEPTHLLYKRLMMYLRLKQSFNFQTIPDFNVFFYSQEPEHQQYREFIVE 1817
            :|.:..:|.|.:..:..:|:|..|..:...|:...:...:.||.|:.||:|.....:..|.:.:.
plant  2061 IPTVSAIFAAETSMILLDPSHEHYVPINKLLKSSSTLKLRGIPLFHDFFWSSAVNFRSQRFWELR 2125

  Fly  1818 LLRCGIKCSADLFLLVSTNTFKVLLGFYGSSLASLETNLLLLSVLSTCVKIPGAVKIMLEHVGIL 1882
            |:..|:|...|:.:.:..:..:.::.|..|.||..||..|:|.|:...||.....:.::|:.|:.
plant  2126 LVYLGLKSDDDVQIYIKNSILETVISFSSSPLADDETKRLILQVVRKSVKFHKIARHLVENCGLF 2190

  Fly  1883 SWLVGVIR--------DTEFHQFDIIEGVISIL--NNL--WYALAASRSELTDYDHIQLRVYR-- 1933
            ||....|.        |.:.|...::|.:..:|  .|:  |    ..|..|.....|..|:|:
plant  2191 SWCSSFISNFTTKPIGDKDLHLVVVLEIITDVLASRNITEW----LQRFGLEGLMEISSRLYKLL 2251

  Fly  1934 ---------------LVLQLLP----------LLSPR--ISVPGLGRLFNVLWKTGSACGQHRAV 1971
                           |:||:|.          :..|.  |::.|:.:||..:...||.  |..|.
plant  2252 GGGLVSVQENGTSVDLILQILSATLKISQKRNMYQPHFTITIEGIFQLFEGVANFGSP--QVEAS 2314

  Fly  1972 SATQMDTLLECVSRQWPDQLASVRYVRSFGSAGACSRSEYCDWLAKDQKLETPAV----LALSSL 2032
            :.:.:.|:|                                        :.||.|    :.:..|
plant  2315 AESGLITIL----------------------------------------MSTPPVDILCMDVDKL 2339

  Fly  2033 REYVI---------DWAQAHK-SESDGETKLLVE-PTE 2059
            |.:::         |:.:..| |||..:||:|:| |.|
plant  2340 RRFLLWGTSTALKSDFKKGSKPSESHEDTKILIEGPQE 2377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12499	NP_651044.1	Npa1	160..475	CDD:288544	75/353 (21%)
CG12499	NP_651044.1	NopRA1	1682..1884	CDD:292818	49/217 (23%)
EMB2788	NP_001320074.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	70	1.000	Domainoid score	I3404
eggNOG	1	0.900	-	-		E1_KOG1791
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D804299at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3385
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13500
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.010