Protein Alignment CG12499 and Urb1

DIOPT Version :9

• Sequence 1: NP_651044.1
• Gene: CG12499 / 42637
• FlyBaseID: FBgn0038968
• Length: 2059
• Species: Drosophila melanogaster
• Sequence 2: NP_001178590.1
• Gene: Urb1 / 304104
• RGDID: 1304621
• Length: 2278
• Species: Rattus norvegicus
• Alignment Length: 2301
• Identity: 495/2301 - (21%)
• Similarity: 807/2301 - (35%)
• Gaps: 701/2301 - (30%)

  Fly    27 VPKKLAKES--------DTPKKKKKKDKTKESFDESTLESTETDPA-DSTPSKKKSKKTKTSDTS 82
            |||:.|.||        .|.|:.:.::.|...|.....::....|| ::..|..|....:.....
  Rat     3 VPKRKASESPGGAASPAGTSKRTRAEEFTGVRFKTQLKDAQGPGPALEAFVSAAKQLPQEDMCDV 67

  Fly    83 VEQQVEVEMAEDEISRDSGIDPEESRIHFPNDFKMMHFRTKLRGNNFITELRHFLHMCSTTRPKL 147
            ||..:::.|...||                                       |..:....||:
  Rat    68 VEGYIKISMECAEI---------------------------------------FQLLSGEKRPE- 92

  Fly   148 AAKYIEKRGKPLELAEAFERI------DKTNLFHVDYLTEALHRVLMEILTNQKSHMESAVHGCR 206
                    .:.|.:.:|||.|      |.|: |||             :.||
  Rat    93 --------SEVLLIFQAFEAILLRTASDLTH-FHV-------------VGTN------------- 122

  Fly   207 YFLKVHGGVLENQMKSM-----QLGHR--RNALKLLTAIVCVEPQLARQVLNSYDVLSNVTVTQK 264
                :...:|.|.||.:     ..|:|  |..|.|:||:|...|:.||.|.:.:|:  |......
  Rat   123 ----IVKKLLNNHMKLLCESLYASGYRMARACLDLMTAVVTQGPEAARDVCSCFDL--NKKALYA 181

  Fly   265 LLSHEKSEYQCEDTVRKAFILFILAFLVEGNTLLIRNILDRGQLIG-VLAKGLVYDDHVTVCVVL 328
            |::  |.:.:....||.|:|.|.|:||:.|:...|..:|:..:.|. :.:.|:..|...|:.::|
  Rat   182 LVT--KRDSKGVHDVRLAYIQFALSFLIAGDDNTIGQVLEIKEFIPCIFSSGIKEDKISTINILL 244

  Fly   329 NALRQYVLENPEIQKTKKVLVFDLECCKNLRRLYDWEGPMGLKVMFAKSKHVSKIPPNPQEAE-- 391
            :.|:..|:.|..|.||:||..|..:...::..||:|.|...:            :|.||:..|
  Rat   245 STLKTKVIHNKNITKTQKVRFFTGQLLNHIAALYNWNGVSDI------------VPENPESTEMS 297

  Fly   392 -------AVSAAVHELLLVLLTSRKHGICF-DA------------MTHYRQKQNKLQGRLLGSLF 436
                   .|...||..|:.|..||||||.| ||            :.|:           |.||.
  Rat   298 AEEAGKAMVRDLVHNFLIDLCCSRKHGISFYDASLGTSGRGGNLTLLHF-----------LLSLK 351

  Fly   437 KPYDNPRKVDLVIQTLTACPDLGRNTVRNCS-SLLSPVKTKPKDLPIAVAFLAQIINAVPPSALS 500
            ....:.....||:..|..||||.....|..: |.|..||:...:   .|..|.:|..|.|  .:|
  Rat   352 TAAGDELVASLVVSILKVCPDLLTKYFREVTFSFLPRVKSTWLN---NVKLLNKIYEAQP--EIS 411

  Fly   501 AAFDKMTLTDFSFWIKELCLPIEALL--------HITGKKYLSDPDFNL-RLAVLRLLLSMMKQY 556
            .|          ||.:|. :|:..||        .:...|.:.....|| .:.|.:..||::
  Rat   412 PA----------FWTREF-IPLPRLLAMVMVTTVPLVCNKIMFTQALNLDSIPVKQSALSLI--- 462

  Fly   557 SNYMNAIAVREQSKKAGNSLRK--------FKFDLLNHLLVHF--------PTIESILYSLYMFI 605
                 :|.::...|...:.|.|        :..:::...:..|        |.:.::::....|.
  Rat   463 -----SIILKRALKTVDHCLDKEIWQDSDVYTAEMMEEFVQLFREALSKILPDLNTVIWVWQSFK 522

  Fly   606 KQKNVE-----------------GVNVLESLSITLDLVML--LCKENRAFVNKTSQILDYLDVLR 651
            ||:..|                 .|:..::.:|.|..|:|  :|...:...:..:|
  Rat   523 KQEIKENHEKGKKSSSKTPAASKAVHRDDAETILLKSVLLQVICLYQQVVPHVVTQ--------- 578

  Fly   652 PLYETDFDKL-------NQPEE---------LLKIQLELKSIKTILLLFPHSLNPTQPLFG---N 697
              |..||.||       ..|.|         :||:.|||.:.|.:.|....  .|...:.|   :
  Rat   579 --YNFDFSKLLKGIISEQGPAEEAPPILQHHMLKVALELPANKFLWLKAQE--GPEAEIVGGERS 639

  Fly   698 VF----KSFIKAYMLEEKSIKSESGNILSRLFQNTGMFDSCRHEINIWIEALIGFGPATVTNVVE 758
            ||    |.|:.:..|:   :|..:..::.::.::||:|:....|:.:|:|.|..........|::
  Rat   640 VFYLLMKMFVNSSHLQ---LKLSTQRLIMKILRDTGVFEHTWRELELWLERLDSTAEKHKETVIQ 701

  Fly   759 ----ILLTILCLDWR---------------QIELPEQSVTDTAIITKNLSKLFAQIE---QGQ-- 799
                ||||::...:.               |..:.:|...|.:|...::..:...::   :|.
  Rat   702 FLERILLTLVVNPYSYTDKASEFVQEASTLQGAVGKQDADDVSIPISHIDDVLDMVDVLVEGSEG 766

  Fly   800 ---------TVQAYVETLTLSKMMPL-------LLKGVELE--EPYDEYVELVFVLLFHYHSKPE 846
                     .....:.|...|.::|.       ||.|.|.|  |....|:..|...:.|....|.
  Rat   767 LDEDIGFLLNEDMILLTFPFSALVPAALEARNKLLLGTECEAGESIVAYMTAVLTDILHTQRDPL 831

  Fly   847 ---IVLQMYE----------DNLSKHTNYMKSWLPGE----------GNGKPKKLP--------- 879
               ::||.|:          ..|::...|...|:|.:          |...|...|
  Rat   832 ALCLLLQSYDKFEPASLLCCQQLAQFHRYYSLWIPEQAQEALPLQVSGTSGPYTPPSSACFSTLL 896

  Fly   880 ------HLIFDK------------WPLLKQMRKVSTESENMSFEQV--FKMDDTENNFELQLEEG 924
                  ..:.||            .||...:|         |.:||  :.....||..:|....|
  Rat   897 QTAYESQTLGDKNVQAKLLAAVPCLPLQHMLR---------SAKQVLLYLKSTVENFSQLGKSVG 952

  Fly   925 QTMLLHSSLGNPRRNMIYVQDLLFVFSHFFTSQKLSKPQAELTADFLIKFLQIASQVDGPEEVQE 989
            .| ||...||..:..:|:.:.|     .....|||...:||  :|..:....:||       ::.
  Rat   953 PT-LLQFLLGLLKHLVIHSEQL-----DTQNQQKLEAARAE--SDLFLDMESVAS-------LEL 1002

  Fly   990 SDDEQQDE--------------------------------------NFTQSMLHYI-----FNHR 1011
            :.|:..:|                                      .|:..:|..:     ..|:
  Rat  1003 ATDKTVEELLVAILKHPTLETWFLALEQKALPPHTLSPVLVKLLAAQFSAGVLQLLVASSPILHK 1067

  Fly  1012 LWQLHPTELLSETSESRLNYVIFLRRLMEHC-------RSLPRFETYTANYRLH------LIKTL 1063
            |.||   .||::.||:....|  ||.|....       ::||:.|   |...||      .|:.:
  Rat  1068 LGQL---GLLAKYSEAITQSV--LRELRTRTVNSAMTPKTLPQLE---ALRELHPYMEGVQIREV 1124

  Fly  1064 DIA-LDTPVDQL---------GNQQQLDE----CVKLVDSFEFNSDQCSQMLDLLTTKVQAKDCI 1114
            .:| |..|...|         |.::||..    .|:|:.|...|..|.|::|
  Rat  1125 TLALLGLPEAHLLTQQGTQCPGKERQLSSLGKTLVQLLTSSHQNRLQSSELL------------- 1176

  Fly  1115 PNGKPNHYFDLLLRLLGRLNTLKEPIDCGKSFKLILTFYKDFGELNEQQLEPFELAVLE------ 1173
                   :....:|.||.|                      ...|.||:|:...|..|:
  Rat  1177 -------WCAEYVRGLGAL----------------------LPTLAEQELDTVFLQTLQKDPVLA 1212

  Fly  1174 -----FLLNYHHHMDECDSEFFACFFTSSRKLSKSAIRLACLLLE-------------RQPRLAE 1220
                 .||.|             |..    :.:|:|:.:|.|||:             .||.:.
  Rat  1213 PVVPADLLEY-------------CLV----RRTKAALDIASLLLQYSSTHLLKFELWCGQPGVG- 1259

  Fly  1221 TFAELLPSNLEQKDLVYPLLDIALTKNYQ-----------IPLPVLQRCYQTYKNGFMKSIEKPQ 1274
                  ||..|..|..:||:.:.|....|           ...|||:..::..::.|. .|..|.
  Rat  1260 ------PSLQEHLDDFFPLIHVYLQHRMQGSFMRPTEVSSAVTPVLRALWRQVRDRFF-HIAGPS 1317

  Fly  1275 KAALIYREHSEASALLIALCMPKS--ECFDYCQKQLK----------LDSVELFQVRVLREIYWQ 1327
            |.||    |.||.|.||.....|.  ...|:....|:          .|||..
  Rat  1318 KHAL----HLEALAQLIPFARTKDLRVLMDHLPNLLRTLSNHKSWIVADSVSA------------ 1366

  Fly  1328 GFAAAKDEKQKATVFVNYINLNVQLLALDLKKQALDLPKLEQISWNCYEWWKTN--RTDDL---- 1386
              |.|:..::.|:.....:...:|.||:....:.   |:.|    |..|..||.  |..:|
  Rat  1367 --ALAESAEELASWRKTLLRSCIQWLAVSFSGRE---PENE----NTQEQEKTMLLRLSELLHAV 1422

  Fly  1387 ----PLDWSRLQKNPQWLNFCKSSLKLALHLGEERLPLQDETNGLVLKLMAFLCDGMYDEYK-ED 1446
                |.||.:         |.|:.||..         .||      |..:..|.|.....|. |.
  Rat  1423 KEVDPGDWQQ---------FVKTGLKFR---------YQD------LTFLRTLLDATKLLYSPES 1463

  Fly  1447 AQQEEDATPTLLYEMICTHSCCFDHLL-GKPSET-----KTHILHLMEVLARKAPSALQSDHIPV 1505
            :...:....::::.|:..||.....:| .|..||     |..:|.||..:.|..||..:|.|..|
  Rat  1464 SGHTKLVQLSVMHMMLTQHSLFLPTMLTSKEEETPDSPVKETLLDLMSTVVRMCPSVCESSHFAV 1528

  Fly  1506 ILGSYHAKLSPADRYGLALLEHYERFDVGLDKFRPFIWGESAVAHY-ALRAADEDVRTRLQQQET 1569
            :||:|.|.||..|:..|.||..||:..:.|..||..:||.:||.|: ..|:..:.:     .|:.
  Rat  1529 LLGTYSATLSILDQKILLLLRAYEQHSLSLISFRVLLWGPAAVEHHKTCRSLGKSL-----WQQP 1588

  Fly  1570 NVAQVLALIVRETSEYTIENFPIWRSLHASQQLPSTEFQNPAKKSMSFGDNQLEQMVEQGQLDFP 1634
            :|..:|.|:..:....||.:||.:|.|..::..               |:.|:          |.
  Rat  1589 SVGDILRLLDPDRMMQTILHFPQYRRLLHTEDT---------------GEPQV----------FK 1628

  Fly  1635 QDLRRICPKRETIYETCYDPAFLLPLMMHCFAPESVVWARWPVQNGLLAITFCGLSSLDKDMRLA 1699
            ....|:      .....|||.|||.|......||.||..|..:.:..|.:|...|||.|..||.|
  Rat  1629 DKTARV------DLSGLYDPCFLLHLFGELTRPEFVVDCRKFLDSNALGLTVAALSSYDPQMRAA 1687

  Fly  1700 AASCQQRYRAHFELSNFYERPLWTQAYENIQAGLADLRNSWLAQRRTHGGTPRVPLIPGLFIAHS 1764
            |......|.:|.|.:.|.|:.......:.::.|:             .....|:|....||||.:
  Rat  1688 AYYVLAAYYSHLEGARFREQSQVLYLLDVVRNGI-------------QAPNLRLPFTVALFIAKA 1739

  Fly  1765 FNLSTEPTHLLYKRLMMYLRLKQSFNFQTIPDFNVFFYSQEPEHQQYREFIVELLRCGIKCSADL 1829
            ......|...:|.::..:|...::.|...:|.|..||||.:.:.:..:|:::|:||.||:.....
  Rat  1740 AAQILRPEEHMYWKISKFLLSHENLNMNKLPGFYQFFYSSDFQQKTEQEWVLEILRQGIRDKHCY 1804

  Fly  1830 FLLVSTNTFKVLLGFYGSSLASLETNLLLLSVLSTCVKIPGAVKIMLEHVGILSWLVGVIRDTEF 1894
            .|......|.::|.|:.|.|........:|.:|.....||.:...::....:|:|::.:: ::.|
  Rat  1805 ELCSRRGVFHIILSFFSSPLCDEVAQNWILEILQNVAHIPRSAYEVIRDYSLLTWILHIL-ESRF 1868

  Fly  1895 HQFDIIEGVISILNNLWYA-----LAASRSEL---TDYDH----IQLRVYRLVLQLLPLLSPRIS 1947
            .:..::..|||:|:.||..     .|..||:|   ||...    :.|.:....|.:|..|:..:.
  Rat  1869 IETQLLSNVISLLHTLWVTNLGSRAAEERSQLPCQTDCHESEKTLALHMVNEFLYVLVALTKHLR 1933

  Fly  1948 VPGLG--RLFNVLWKTGSACGQHRAV 1971
             |.|.  :|.:..|...|.......|
  Rat  1934 -PTLASTQLMDFFWTLESVLSYRATV 1958

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12499	NP_651044.1	Npa1	160..475	CDD:288544	93/351 (26%)
		NopRA1	1682..1884	CDD:292818	49/201 (24%)
Urb1	NP_001178590.1	Npa1	78..396	CDD:288544	100/426 (23%)
		NopRA1	1670..1859	CDD:292818	49/201 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347749
Domainoid	1	1.000	84	1.000	Domainoid score	I8098
eggNOG	1	0.900	-	-		E1_KOG1791
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	243	1.000	Inparanoid score	I3226
OMA	1	1.010	-	-		QHG47560
OrthoDB	1	1.010	-	-		D352351at33208
OrthoFinder	1	1.000	-	-		FOG0006129
OrthoInspector	1	1.000	-	-		oto97238
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13500
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.960