DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12499 and SPCC14G10.02

DIOPT Version :9

Sequence 1:	NP_651044.1	Gene:	CG12499 / 42637	FlyBaseID:	FBgn0038968	Length:	2059	Species:	Drosophila melanogaster
Sequence 2:	NP_587943.2	Gene:	SPCC14G10.02 / 2539162	PomBaseID:	SPCC14G10.02	Length:	1568	Species:	Schizosaccharomyces pombe

Alignment Length:	1946	Identity:	359/1946 - (18%)
Similarity:	648/1946 - (33%)	Gaps:	643/1946 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 VDYLTEALHRVLMEILTNQKSHMESAVHGCRY---FLKVHGGVLENQMKSMQLGHRRNA----LK 233
            :|...:.|.|||:|    ..:|:|..:....:   .|:....:|::.:|.:......|:    |.
pombe     8 LDKEIDELSRVLLE----HPAHVEKVLKTVEFDKSALRYIDAILDHHLKQIYRNLTSNSPLHTLS 68

  Fly   234 LL-------TAIVCVEP---------------QLARQVLNSY--DVLSNVTVTQKLLSHEKSEYQ 274
            ||       ..:.||..               ||..|:.||.  :....:|:::|
pombe    69 LLQKMASWNNGLACVRVFQAIDWNSKIFIKMLQLPNQIQNSRKGNKRLKITISKK---------- 123

  Fly   275 CEDTVRKAFILFILAFLVEGNTLLIRNILDRGQLIGVLAKGLVYDDHVTVCVVLNALRQYVLENP 339
                 |.:.:|..:.||..|...:...||:..:|...|.||:..|:...:..:|.....|||.:.
pombe   124 -----RSSLLLLFITFLRLGTPEIRLEILNSRKLTTPLFKGIYNDEPSVLKELLQCWLTYVLLDH 183

  Fly   340 EIQKTKKVLVFD---LECCKNLRRLYDWEGPMGLKVMFAKSKHVSKIPPNPQEAEAVSAA--VHE 399
            ::.:..|:..|:   |.|   |..||.                      ...|.:.:|..  ||:
pombe   184 DVSRATKLSYFNEWSLSC---LASLYS----------------------RDDEIDGISLCNLVHK 223

  Fly   400 LLLVLLTSRKHGICFDAMTHYRQK----QNK-LQGRLLGSL---FKPYDNPRKVDLVIQTLTACP 456
            ..:...|....|:||.:...:.||    |:| :..|:|.|.   ...:.:..:.:||::.|.|||
pombe   224 FFVDACTVPGEGLCFVSNGWHLQKKVDGQSKTIFNRVLQSFVFSLHVHTSTLQRELVLKILKACP 288

  Fly   457 DLGRNTVRNCSSLLSPVKTKPKDLPIAVAFLAQII--------------NAVPPSALSAAFDKMT 507
            |:..:.:...|....||.:...   |:...|.|.|              ..|||:.:
pombe   289 DITASFIERNSLTSEPVLSYQW---ISFVSLLQAILGMGIPFPFYDAETRTVPPTNI-------- 342

  Fly   508 LTDFSFWIKELCLPIEALLHITGKKYLSDPDFNLRLAVLRLLLSMMKQYSNYMNAIAVREQSKKA 572
                   |.|..||                                   |::...:.:     ||
pombe   343 -------IIENILP-----------------------------------SSFSKPVVL-----KA 360

  Fly   573 GNSLRKFK-FDLLNHLLVHFPTIESILYSLYMFIKQKNVEGVNVLESLSITLDLVMLLCKENRAF 636
            .|...||. |..:|.||..|..:||:|..    ||:..:...|.:|.:|...|.::|...:::.|
pombe   361 LNGNDKFVCFLTVNTLLASFKRLESVLDE----IKRSELSEDNKVELVSKISDAILLRLPDSQTF 421

  Fly   637 VNKTSQILDYLDVLRPLY-ETDFDKLNQ-------------PEELLKIQLELKSIKTILLLFPHS 687
            |.              || .|:.|.|.:             ||.:||::::.
pombe   422 VQ--------------LYSSTESDLLKEGLSRILLYFFTYFPENILKLKIDT------------- 459

  Fly   688 LNPTQPLFGNVFKSFIKAYMLEEKSIKSESGNILSRLFQNTGMFDSCRHEINIWIEALIGFGPAT 752
                                           :|..||..:.||.|.             .|....
pombe   460 -------------------------------SIFLRLDLSPGMLDR-------------PFSRLH 480

  Fly   753 VTNVVEIL---------------LTILCLDWRQIELPEQSVTDTAIITKNLSKLFAQIEQGQTVQ 802
            |.|:::||               ...|||.:  ::.....:.|..|.|  |:.:|:     ||:
pombe   481 VENIIQILRYLPEVKWFDVVRSPFVFLCLMY--LQTSHSKLRDAIIST--LNDVFS-----QTI- 535

  Fly   803 AYVETLTLSKMMPLLLKGVELEEPYDEYVELVFV---------LLFHYHSKPEIVLQMYEDNLSK 858
            .:..:|.:..:: .:|..::...|......|.|:         .:|.|       |.:..|...|
pombe   536 IFCPSLAVPPIL-TILASLQHTSPTQHKAVLEFLNSCINRCISRVFAY-------LDVCVDCFKK 592

  Fly   859 HTNYMKSWLPGEGNGKPKKLPHL------IFDKWPLLKQMRKVSTESEN--MSFEQVFKMDDTEN 915
            |:          .|.:.|..|.:      :.::.|...|.|.:|.:|::  :|:     :.|..:
pombe   593 HS----------VNSQKKTAPEVSPISVTLIEQIPFFLQKRDISDDSKDAVLSW-----LSDLFS 642

  Fly   916 NFELQLEEGQTMLLHSSLGNPRRNMIYVQDLLFVFSHFFTSQKLSKPQAELTADFLIK-FLQIAS 979
            |.....|:...:.                       |...:..::    ...:|:.:| |.|:.|
pombe   643 NLVCTGEDANCLF-----------------------HLLENVNVT----AFDSDYTLKPFNQLMS 680

  Fly   980 QVDGPEEVQESDDEQQDENFTQSMLHYIFNHRLWQLHPTELLSETSESRLNYVIFLRRLMEHCRS 1044
            .::. ..||:..|                                      ||       ....|
pombe   681 FIES-LAVQKLPD--------------------------------------YV-------NQIGS 699

  Fly  1045 LPRFETYTANYRLHLIKTLDIALDTPVDQLGNQQQLDECVKLVDSFEFNSDQCSQMLDLLTTKV- 1108
            |.::..|:.|                 |:|.|..        :..|..|.|.....:.::|.::
pombe   700 LSQYLLYSTN-----------------DELSNSG--------IQKFGMNLDFLPLYVVIITKRIA 739

  Fly  1109 ---QAKDCIPNGKPNHYFDLLLRLL-----GRLNTLKEPIDCGKSFKLILTFYKDFGELNEQQLE 1165
               |:.|.    :...:.:|:..|:     ..:.|.:.||....|..:.|..:     |.::|..
pombe   740 IMLQSGDM----RVKKFLELIRELVEFSKEETMATSQSPIRTLLSACINLRPF-----LLQEQYI 795

  Fly  1166 PFELAVLEFLLNYHHH-----MDECDSEFFACFFTSSRKLSKSAIRLAC--LLLERQPRLAETFA 1223
            .|.:...|||::.:..     ::.|..:|....|:...:.:.:.||:|.  :||..|.... .|:
pombe   796 SFNMDFAEFLIDTNASIKGSVVNTCVLDFLYKSFSDKVQENYNLIRIAAKFMLLWTQEEFI-GFS 859

  Fly  1224 ELLPSNL-EQKDLVYPLLDIALTKNYQIPLPVLQRCYQ----TYKNGFM-KSIEKPQKAALIYRE 1282
            :.|.|.| |..||:|        ||.....|:|..|.|    |..|.|. .||....|||:: :.
pombe   860 KALDSFLSENDDLIY--------KNLDYVAPLLFECMQFTSTTNANMFSNNSISVLLKAAIL-KP 915

  Fly  1283 HSEASALLIALCMPKSECFDYCQKQLKLDSVELFQVRVLREIYWQGFAAAKDEKQKATVFVNYIN 1347
            ......:..||...|....|:...:..|.:||.|.:.          ..|.::....:.|||::.
pombe   916 TKLTHGMFDALNTMKPIISDFTVFEPALHTVENFDLT----------DCADEQILLLSSFVNFVP 970

  Fly  1348 LNVQLL--ALDLKKQALDLPKLEQISWNCYEWWKTNRTDDLPLDWSRLQKNPQWLNFC----KSS 1406
            |..:::  .|...|:|| :.|.|.::..|.:..|....:....|..|::      :||    :::
pombe   971 LFRKVIWNLLLNNKEAL-IQKYELLAILCCDLAKQYVAEQSQYDLERIR------SFCSEVVENN 1028

  Fly  1407 LKLAL---HLGEERLPLQDETNGLVLKLMAFLCDGMYDEYKEDAQQEEDATPTLLYEMICTHSCC 1468
            |.|.|   ||.|...||        :||                     :.|.:.|.:..:::..
pombe  1029 LDLVLQKSHLIELLFPL--------MKL---------------------SDPKIQYYVKVSNALS 1064

  Fly  1469 FDHLLGKPSETKTHILHLMEVLARK--APSALQSDHIPVILGSYHAKLSPADRYGLAL---LEHY 1528
            ..:|       ...:|.|:.:|.::  .||:|:...|..|.......||.:.:.||:|   |.::
pombe  1065 EKYL-------PQGVLELLVLLQKRIDIPSSLRVQTIMRIFAILTRVLSDSPQIGLSLEKFLTNF 1122

  Fly  1529 E----------RFDVGLDKFRPFIWGESAVAH--------------YALRAADEDVRTRLQQ--- 1566
            |          |.::.......|:  |||:.|              :.:.|...|....||.
pombe  1123 EALIKMNVDILRDEIDKSTLNSFL--ESAIVHVTSFSNLRLCLTLAFTMTAEQCDSSRFLQMILA 1185

  Fly  1567 QETN-----------VAQVLALIVRET-------------------SEYTIENFPIWRSLHASQQ 1601
            .|.|           .|.:.|:|.:.|                   ..||:.:..:...|...:.
pombe  1186 HEKNPLAGEDSSDEIKATMSAIICKLTIIGKNYTLSVLDQILKLFKGRYTLHDSLLCELLAYFET 1250

  Fly  1602 LPSTEFQNP---------------AKKSMSFGDNQLEQMVEQGQLD-FPQDLRRICPKRETIYET 1650
            |......:.               |:|.   |...||..:....:: :|.:..:|..|.....||
pombe  1251 LDDISVASRYKGWVITDEYDMMLLARKD---GSGVLEPKIAANTVNQYPSEWEKIDLKVFDDLET 1312

  Fly  1651 --------C--------YDPAFLLPL---MMHCFAPESVVWARWPVQNGLLAITFCGLSSLDKDM 1696
                    |        |.|.:.|.:   ::|  :.:.|...:..||...|.:...|||...::.
pombe  1313 TEGLLSSYCSNEWNREVYHPLYALGITASLLH--SNQQVSNIQVIVQQNFLGMIVMGLSLFKEEA 1375

  Fly  1697 RLAAASCQQRYRAHFELSNFYERPLWTQAYENIQAGLADLRNSWLAQRRTHGGTPRVPLIPGLFI 1761
            |.|..:..:.:....:...|.|:.|......:|...:....|             |:..:...|.
pombe  1376 RFACLNFLRNFIPILDEQKFREKHLIKLVLASIIVNVPSSEN-------------RLSTLMANFY 1427

  Fly  1762 AHSFNLSTEPTHLLYKRLMMYLRLKQSFNFQTIPDFNVFFYSQEPEHQQYREFIVELLRCGIKCS 1826
            |.|..:..:|||.|:..:..|...:|..:...||.:....| ...::.:...:::.||..|::.:
pombe  1428 AFSLTVMMKPTHPLFVGINRYYLQRQHVDVTDIPMYYELLY-PSTDYTKSVYWLLTLLHAGLQTN 1491

  Fly  1827 ADLFLLVSTNTFKVLLGFYGSSLASLETNLLLLSVLSTCVKIPG--------AVKIMLEHV 1879
            .||.:.:..:.|:::...|.|.:.:.|...|:..:|...|.:.|        |:..||:.|
pombe  1492 QDLKIYLRRHVFEMICTLYNSCVVNSEIRTLIEKILLKVVALGGGPMLVKYNAIYPMLQMV 1552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12499	NP_651044.1	Npa1	160..475	CDD:288544	72/342 (21%)
CG12499	NP_651044.1	NopRA1	1682..1884	CDD:292818	41/206 (20%)
SPCC14G10.02	NP_587943.2	Npa1	28..312	CDD:288544	64/326 (20%)
SPCC14G10.02	NP_587943.2	NopRA1	1361..1545	CDD:292818	37/197 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1791
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006129
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13500
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1908
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.030