Protein Alignment CG12499 and urb1

DIOPT Version :9

• Sequence 1: NP_651044.1
• Gene: CG12499 / 42637
• FlyBaseID: FBgn0038968
• Length: 2059
• Species: Drosophila melanogaster
• Sequence 2: NP_001313374.1
• Gene: urb1 / 100536352
• ZFINID: ZDB-GENE-030131-5181
• Length: 2234
• Species: Danio rerio
• Alignment Length: 2365
• Identity: 485/2365 - (20%)
• Similarity: 846/2365 - (35%)
• Gaps: 638/2365 - (26%)

  Fly    47 TKESFDESTLESTETDPADSTPSKKKSKKTKTSDTSVEQQVEVEMAEDEISRDSGIDPEESRIHF 111
            ||...:|:..||.           .|:||.||.::.....|...|.:|......|
Zfish     3 TKRENEENITESV-----------TKAKKGKTDESEFSGTVFKSMLKDSSEAQKG---------- 46

  Fly   112 PNDFKMMHFRTKLRGNNFITELRHFLHMCSTTRPKLAAKYIEKRGK---PLELAEAFERIDKTN- 172
                                 |..|:.:..|.  ..|..|....|.   ..|.:|.|..:|:..
Zfish    47 ---------------------LATFIRVAKTL--PCAELYDVVEGYIKISAECSEIFALLDEEKP 88

  Fly   173 ------LFHVDYLTEALHRVLMEILTNQKSHMESAVHGCRYFLKVHGGVLENQMKSMQLGHRRNA 231
                  :|      :.|..:|:...::.........:..|..:..|..:|::.:.|......|..
Zfish    89 EKEMMLIF------QCLEMILLRTASDLSQFSMVGANIVRRIVSKHMTLLQSSLYSKNYRFVRQC 147

  Fly   232 LKLLTAIVCVEPQLARQVLNSYDVLSNVTVTQKLLS-HEKSEYQCEDTVRKAFILFILAFLVEGN 295
            |.||:|:|......||      ||...:...:.|.. ..|.:...:..||.|||.|:|:||:.|:
Zfish   148 LSLLSALVSQSADAAR------DVFGQMQFGKDLCQLARKRDKSGKSDVRMAFIQFVLSFLMSGD 206

  Fly   296 TLLIRNILDRGQLIGVLAKGLVYDDHVTVCVVLNALRQYVLENPEIQKTKKVLVFDLECCKNLRR 360
            ...|..|||..:|..:|..||..|....:.::|:.|:..|::|..|.||:||..|.......:..
Zfish   207 NTTIGQILDTKELSEILNSGLKEDRLSIINLILSTLQTKVVQNKTITKTQKVRFFSASILAQIAS 271

  Fly   361 LYDWEGPMGLKV-----MFAKSKHVSKIPPNPQEAEAVSAAVHELLLVLLTSRKHGICF--DAMT 418
            ||.|.|.:.:.|     :....||:.:            ..||..|:.|..||||||.|  .::.
Zfish   272 LYRWNGIVDVSVDEEEKVEEGGKHIMR------------ELVHNFLMDLCCSRKHGISFHDPSLG 324

  Fly   419 HYRQKQNKLQGRLLGSLFKPYDNPRKVDLVIQTLTACPDL---------------GRNTVRNCSS 468
            ...:..|.:..:.|..|.:..::....:||:..|...||:               ...|.::..|
Zfish   325 TAGKVGNLVLLQFLVRLKQATEDEMVAELVVNVLKGSPDILNRYFKETQCSFAPRNNKTWQDNIS 389

  Fly   469 LL------SPVKTKPKDLPIAVAF---LAQI-INAVPP-----------SALSAAFDKMTLTDFS 512
            ||      .||.:|...:...|.|   |:.: :.::||           :..|......||:..:
Zfish   390 LLKKIYEVQPVVSKAFQMNEMVPFPRLLSMVLVTSLPPVCNKVFFTQGLNVHSLVVQHTTLSLLA 454

  Fly   513 FWIK------ELCLPIEALLHITGKKY---LSDPDFNL-RLAVLRLLLSMMKQYSNYMNAIAVRE 567
            |.:|      |.||  :..:..|...|   :.:....| |.|:.::|..|:...|.:......:|
Zfish   455 FILKRAQQNIEYCL--DRTVWETSDIYSPAMMEEFVQLYREALSKILPDMVSIVSIWQLHSKEKE 517

  Fly   568 QSKKAGNSLRKFKFDLLNHLLVHFPTIESILYSLYMFIKQKNVEGVNVLESLSITLDLVMLLCKE 632
            .:.|..|..:|...:.......|...::::|..: |.:.||.|..: |.:|   ..|...||
Zfish   518 DAAKMKNRKQKQSQEHSQQDDPHLILVKALLLQV-MCLYQKVVPHL-VTQS---RFDFSKLL--- 574

  Fly   633 NRAFVNKTSQILDYLDVLRPLYETDFDKLNQPEELLKIQLELKSIKTILLLFPHSLNPTQPLFGN 697
             :..|.::....:...||:             .::|::.|||.:.|..........||.   |..
Zfish   575 -KGIVTESGMTQEVPPVLQ-------------YQILQLALELPASKFSWFRVQEMANPD---FEK 622

  Fly   698 VFKSFI----KAYMLEEKS-IKSESGNILSRLFQNTGMFDSCRHEINIWIEALIGFGPATVTNVV 757
            ..||.|    |.::....| :|:.|..::.::.:::|:|:....|:.:|::.|...|.:....|:
Zfish   623 GEKSVIYLLLKMFVSSNNSYLKTSSRMLVLKVLRDSGVFEHTWKELELWLDHLTMLGLSQQETVI 687

  Fly   758 E----ILLTILC-------------------------LDWRQIELPEQSVTDTA----IITKNLS 789
            :    :|..::|                         .|..:..:|...:.|..    :|.::..
Zfish   688 QFLDHVLTRVVCNSHVYTDKAASMVQEAANLQANLNGQDGDEASIPISHIDDVLDMVDVIVESSE 752

  Fly   790 KLFAQIEQGQTVQAYVETLTLSKMMPLLL-------------KGVELEEPYDEYVELVFVLLFHY 841
            ....:|....|....::|...|.::|.:|             |||     ..||:..|...:.|.
Zfish   753 GDIEEIGPSLTEDIILQTFPFSAVVPAVLEARNKLPDSFKDAKGV-----LYEYMAAVLCDVLHC 812

  Fly   842 HSKPE---IVLQMYEDNLS-------KHT------NYMKSWLPGEGNGKPKKLPHLIFDKWPLLK 890
            ...|.   :.||.|:..||       .|.      :|...||       ||...|.:|..
Zfish   813 QRDPLALCLTLQHYDKELSTSDAASTPHASVVSFYHYYSQWL-------PKNTHHTLFIS----- 865

  Fly   891 QMRKVSTESENMSFEQVFKMDDTE-------NNFELQLEEGQTMLLHSSLGNP---RRNMIYVQD 945
              ...:....:..|..:.|...||       .:|:..|:|....|..|.:  |   .:.::|:::
Zfish   866 --ESFTDGGSHADFTALLKTSFTEGANAFLRTSFKEALQEALATLTVSRI--PVAVNQVLLYLRN 926

  Fly   946 LLFVFSHFF---TSQKLSKPQAELTADFLIKFLQIASQVDGPEEVQESDDEQQDENFTQSMLHYI 1007
            .:..|:...   .::.||.....|.| .::|.|  :|....|.|.:.:....:|..|
Zfish   927 YVLNFNMLLKETAAEVLSSLMMVLNA-LILKLL--SSDTHTPVESESAGQHDEDALF-------- 980

  Fly  1008 FNHRLWQLHPTELLSETSESRLNYVIFLRRLMEHCRSLPRFETYTANYRLHLIKTLDIALDT--- 1069
                   |...::.:|.::.:...:..|:.:.:|    |..|.:.            :||:.
Zfish   981 -------LDTNQVPAENTDKQQIVLAVLKSVFKH----PAVEQWF------------LALELSSF 1022

  Fly  1070 PVDQLGNQQQLDECVKLVDS----FEFNSDQCSQM--LDLLTTKVQAKDCIPNGKPNHYFDLLLR 1128
            |...|...:....||.|.:.    .|.::|....:  |:|::|.:.:        |..      .
Zfish  1023 PPHSLNPVRLKQLCVCLTEMTLLLLESSADTLRDLDALELISTYLTS--------PQR------A 1073

  Fly  1129 LLGRLNTLKEPIDCGK----SFKLILTFYKDFGELNEQQLEP--FELAVLEFLLNYHHHMDECDS 1187
            :|..|..:|.  :|.|    |.:.:|..        ::.:||  |:..|...||....|:...::
Zfish  1074 VLRELQEMKS--NCPKKESLSVRALLAL--------QEYIEPSSFKEVVSTLLLLPQKHLLAPEN 1128

  Fly  1188 EFFACFFTSSRKLSKSAIRLACLLLERQPRLAETFAELLPSNLEQKDLVYPLLDIALTKNYQIPL 1252
            :......|..:.||.|        |:|...::.:...|.|::|:....::........:::.  |
Zfish  1129 QLSVYGRTVQKLLSDS--------LKRSSAVSSSCVTLSPAHLQGLAALFTSCQCVQLEDFL--L 1183

  Fly  1253 PVLQRCYQTYKNGFMKSIEKPQKAALIYREHSEA---SALLIALCMPKSECFD-YC-----QKQL 1308
            .||.|     :.|..|.|:.......|.||...|   ..:|:..|......|: :|     |||:
Zfish  1184 QVLSR-----EPGTAKLIQTDILLHCIQRESPSAQDIGVVLLENCSTHVLSFELWCLDPSNQKQI 1243

  Fly  1309 KLDS------------------------VELFQVRVLREI----YW----QGFAAAKDEKQKATV 1341
            .:.:                        |:...::||:..    .|    ||.|..     :..:
Zfish  1244 SVQNGSFLSLLNSYLKRSTADDPTRPKDVQKSVLKVLKNALMAELWHTVQQGEAGV-----RTAL 1303

  Fly  1342 FVNYINLNVQLLAL--DLKKQALDLPKLEQISWNCYEWWK------TNRTDD------------- 1385
            .|..::..::|.|:  ||.:...|||.:.| ..:.||.||      ....||
Zfish  1304 HVEVLSSLIRLAAVNSDLIQLIKDLPAILQ-KPDTYERWKLADSISEKLCDDSEELHQWRKSLLS 1367

  Fly  1386 LPLDW----SRLQKNPQ----------------------------WLNFCKSSLKLALHLGEERL 1418
            ..|.|    .:.||.||                            |..|.||.||...|
Zfish  1368 AALVWLTAVYKKQKEPQSNHEESMLTRLRSLLLGQIFPENMTASDWNAFVKSGLKHRYH------ 1426

  Fly  1419 PLQDETNGLVLKLMAFLCDGMYDEYKEDAQQEEDATPTLLYEMICTHSCCFDHLLGKPSE----T 1479
                :.|  .|:.:..|.:.:||  ..|..:|.....| ::.|..|||.....:|...::    |
Zfish  1427 ----DCN--FLETLNSLVEVIYD--TPDTPKEMLPVAT-IHMMTTTHSLFLPTMLAIDTDSLRLT 1482

  Fly  1480 KTHILHLMEVLARKAPSALQSDHIPVILGSYHAKLSPADRYGLALLEHYERFDVGLDKFRPFIWG 1544
            |..::.|:..|.||:|.....:|..|:||:|.|.||..|:..|.:|:.||:.::.|.:|:..:||
Zfish  1483 KESLVSLLLTLVRKSPEVCNVNHFLVLLGAYEASLSTTDQKLLLVLQEYEKNNISLAEFQFVLWG 1547

  Fly  1545 ESAVAHYALRAADEDVRTRLQQQETNVAQVLALIVRETSEYTIENFPIWRSLHASQQLPSTEFQN 1609
            .:||.|:..|   :.:...|.|:.|: ..:|:|:..:....|:.:||..|.:     :|.
Zfish  1548 PAAVEHHKTR---KSLGPSLWQKPTS-EHLLSLLSADRMLNTVTHFPQRRYI-----IPQ----- 1598

  Fly  1610 PAKKSMSFGDNQLEQMVEQGQLDFPQDLRRICPKRETIYETCYDPAFLLPLMMHCFAPESVVWAR 1674
             ..|:|.:        :::|             ||.....:.|||.|||||......||..|...
Zfish  1599 -VNKTMIY--------IQEG-------------KRSVDLSSLYDPCFLLPLFSFILQPECAVDCL 1641

  Fly  1675 WPVQNGLLAITFCGLSSLDKDMRLAAASCQQRYRAHFELSNFYERPLWTQAYENIQAGLADLRNS 1739
            ..|....|.:|...|||.|..:|.||......:..|.|.:.|.|:.......:.::.|:
Zfish  1642 KFVSCQALGVTMAALSSYDSKVRAAAYQVLGSFYQHLEGARFKEKRQLLYLLDTVKNGI------ 1700

  Fly  1740 WLAQRRTHGGTPRVPLIPGLFIAHSFNLSTEPTHLLYKRLMMYLRLKQSFNFQTIPDFNVFFYSQ 1804
               |::    ..|||.:...:||........|...:|..:..:|...|..:.:.:|||...|||.
Zfish  1701 ---QKQ----NLRVPFVHVAYIAKVAQQILRPEEHMYMVVSRFLLGTQFLDLKRVPDFFKLFYSF 1758

  Fly  1805 EPEHQQYREFIVELLRCGIKCSADLFLLVSTNTFKVLLGFYGSSLASLETNLLLLSVLSTCVKIP 1869
            |.||:..||:|:.:|..|:...:...|......::.||.|..:||....|.:.::.||....::.
Zfish  1759 ELEHKLEREWILSVLEEGVWDQSCYELCEMQRIYQTLLAFASTSLCDQATQIQIVRVLRQTARVN 1823

  Fly  1870 GAVKIMLEHVGILSWLVGVIRDTEFHQFDIIEGVISILNNLWY---------ALAASRSE----- 1920
            .|..|:.:..|:|:|:|.:| :..:....::..||.:|:.||:         |.|:|.|.
Zfish  1824 RAAYILTKEHGVLTWIVQLI-EKRYVDSKLLSSVIELLHALWFTNLGDKESKAEASSTSSEQPQT 1887

  Fly  1921 -----------------LTDYDHIQLRVYRLVLQLLPLLSPRISVPGLGRLFNVLWKTGSACGQH 1968
                             ||...|::..|..|.||..           |..|.:||...|:|...:
Zfish  1888 SGKCLPLPIINEFLCTLLTVIRHLRSGVSGLQLQQF-----------LHTLSSVLVHCGTAMNAY 1941

  Fly  1969 R----------AVSATQMDTLLECVSRQWPDQLASVRYVRSFGSA-------------------- 2003
            :          .:|.:::.:||:    :|    .::.:..|..||
Zfish  1942 KEAGWLTLHPHKLSCSEVLSLLQ----RW----TALSHDASLASALQTVGNKHKVKELMGSGREK 1998

  Fly  2004 --GACSRSEYC-----------------------------DWLAKDQKLET---------PAVLA 2028
              |.|..:::.                             .|..|:::|.|         ||...
Zfish  1999 GQGKCHSTKHAPMEKQTENAEVLDQAVLDECKPHLRNILLHWEPKEKELSTSTSQTVSDKPASSG 2063

  Fly  2029 LSSLREYVI-DWAQAHKSESDGETK 2052
            ||:....|| .||....:||..:.|
Zfish  2064 LSNTTACVIFKWALKTLTESRFDDK 2088

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12499	NP_651044.1	Npa1	160..475	CDD:288544	84/350 (24%)
		NopRA1	1682..1884	CDD:292818	51/201 (25%)
urb1	NP_001313374.1	Npa1	76..387	CDD:288544	78/334 (23%)
		NopRA1	1649..1838	CDD:292818	51/201 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589289
Domainoid	1	1.000	106	1.000	Domainoid score	I6515
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	260	1.000	Inparanoid score	I3107
OMA	1	1.010	-	-		QHG47560
OrthoDB	1	1.010	-	-		D352351at33208
OrthoFinder	1	1.000	-	-		FOG0006129
OrthoInspector	1	1.000	-	-		oto39009
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13500
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	10.100