DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pinta and TTPAL

DIOPT Version :9

Sequence 1:	NP_001287466.1	Gene:	pinta / 42635	FlyBaseID:	FBgn0038966	Length:	273	Species:	Drosophila melanogaster
Sequence 2:	NP_001034288.1	Gene:	TTPAL / 79183	HGNCID:	16114	Length:	342	Species:	Homo sapiens

Alignment Length:	261	Identity:	74/261 - (28%)
Similarity:	117/261 - (44%)	Gaps:	25/261 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 PERVLAQVQDLSDWLVANPQINGCNTFEN--LHFFLRTSKFDVERAKKKLKTFYQMRAERTEWFD 81
            ||..|..||.|.| :|.....|...:.::  |..|||..|||.:||.:.|..::..|....|.|:
Human    51 PEWRLRDVQALRD-MVRKEYPNLSTSLDDAFLLRFLRARKFDYDRALQLLVNYHSCRRSWPEVFN 114

  Fly    82 NRDPQLPEIQDLLKLGVFLPIGPDAEQR--MVVVIRTAAHDPKLHSQNNVFKTSKMILDLLLKLD 144
            |..|.  .::|:|..| ||.:.|..:.|  .||.||.....|..:......:...:.|:.|::.:
Human   115 NLKPS--ALKDVLASG-FLTVLPHTDPRGCHVVCIRPDRWIPSNYPITENIRAIYLTLEKLIQSE 176

  Fly   145 PETCARGMVAILDMQGVQLGHALQMNPKLIKRSVE-SWTAYPCQPKLLEFTNAPRHVNFFLNTFR 208
             ||...|:|.:.|.:||.|..|....|.:.|:.:. ....:|.:.|.:...|.||   .|...|.
Human   177 -ETQVNGIVILADYKGVSLSKASHFGPFIAKKVIGILQDGFPIRIKAVHVVNEPR---IFKGIFA 237

  Fly   209 I---FMTPKIRSRLFVRREG-----TSVSCDQLPKELGGQGLSYMEL-SVKWKQLVEENADFYVE 264
            |   |:..||.:|.|:....     |::....||||.||   :..|| :..|..::..:.|.:|:
Human   238 IIKPFLKEKIANRFFLHGSDLNSLHTNLPRSILPKEYGG---TAGELDTATWNAVLLASEDDFVK 299

  Fly   265 Q 265
            :
Human   300 E 300

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pinta	NP_001287466.1	SEC14	87..240	CDD:238099	44/163 (27%)
TTPAL	NP_001034288.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		CRAL_TRIO_N	56..102	CDD:215024	16/46 (35%)
		SEC14	121..277	CDD:238099	45/163 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1471
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D559280at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10174
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920