DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lqfR and TELO2

DIOPT Version :9

Sequence 1:	NP_732736.2	Gene:	lqfR / 42632	FlyBaseID:	FBgn0261279	Length:	1415	Species:	Drosophila melanogaster
Sequence 2:	XP_011521075.1	Gene:	TELO2 / 9894	HGNCID:	29099	Length:	899	Species:	Homo sapiens

Alignment Length:	1009	Identity:	230/1009 - (22%)
Similarity:	374/1009 - (37%)	Gaps:	256/1009 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   512 QPPSEAMRLAFSKAQKQLRDLMQVQSAS--------AVAQVAAILGELHNSNALPGFTTPEQLVG 568
            :|....:|||       :|:.:...|:|        .:..:...|||: ...|||
Human     2 EPAPSEVRLA-------VREAIHALSSSEDGGHIFCTLESLKRYLGEM-EPPALP---------- 48

  Fly   569 LDRQTCDWTCLAHGEYAALLNQLTELFSQDWPEPSQDVEVVNIFKLDHSFDYVSVAFESLQTRLD 633
              |:..::   |...::.:|..|....|..|.|           .|.|.             ||:
Human    49 --REKEEF---ASAHFSPVLRCLASRLSPAWLE-----------LLPHG-------------RLE 84

  Fly   634 KFPSTISSLLENMVKDESLI-----------SIALLHISRQRASLMQRFAR--TIKVMPERKVEE 685
            :.  ..|..||.......|:           |..|:.::|    |:.||.|  .:.|:.|.:..:
Human    85 EL--WASFFLEGPADQAFLVLMETIEGAAGPSFRLMKMAR----LLARFLREGRLAVLMEAQCRQ 143

  Fly   686 LDAQVKAFFQLL--------ISLPAQVANRLGRRLPETFAPVSYQKLLLRQWLKSLHFVLQCDDN 742
               |.:..|.||        ::||..:.|||.:.....|.|.:|.:||..:.::    |||...:
Human   144 ---QTQPGFILLRETLLGKVVALPDHLGNRLQQENLAEFFPQNYFRLLGEEVVR----VLQAVVD 201

  Fly   743 REYFDLEPYSWLLSQAINLIYDVSTLESLLRVLKDYAVAPR----------GRKVVHTILKELDP 797
            .....|:.....:||.:.........:.:|.||     .||          .::|...:::::..
Human   202 SLQGGLDSSVSFVSQVLGKACVHGRQQEILGVL-----VPRLAALTQGSYLHQRVCWRLVEQVPD 261

  Fly   798 AACLKTAQSALSAGLN---LYVLIGAATLETPHWKHCLLQKLPLQRTPVDNKQLITLASYL---N 856
            .|........:.|.|.   |..|:|...::....:..:.|||...::.:....|.:|..:|   :
Human   262 RAMEAVLTGLVEAALGPEVLSRLLGNLVVKNKKAQFVMTQKLLFLQSRLTTPMLQSLLGHLAMDS 326

  Fly   857 AVAPAQLQVLLNQLLGIW--SKRISLQKLGSQEHLAISKLLVLAAKCLCGNLVMDLNIQR----- 914
            ...|..||| |.:||..|  |..|....|..|.|  :||.:::   ||......:|...|
Human   327 QRRPLLLQV-LKELLETWGSSSAIRHTPLPQQRH--VSKAVLI---CLAQLGEPELRDSRDELLA 385

  Fly   915 QLHDGLSNHLQSPDALQRHVGMKTVELIFNFIALPDAKEDDRLRFEYDSFKDTFHWHIFEEFD-E 978
            .:..|:...|.|.....|.:||...|::...|    ..|...|:|:|:.          :|.. |
Human   386 SMMAGVKCRLDSSLPPVRRLGMIVAEVVSARI----HPEGPPLKFQYEE----------DELSLE 436

  Fly   979 LGQFESPSKTKLDEKPCEDQLKQLELHLSDFMSTTEQKEPHKPNIEIQANPAPENQNVNMQLDSD 1043
            |....||       :|..|...  |...|...:|.|  .|.:...||.....|:.|....  |||
Human   437 LLALASP-------QPAGDGAS--EAGTSLVPATAE--PPAETPAEIVDGGVPQAQLAGS--DSD 488

  Fly  1044 DDEPLDEDDDELKPYDMSNDTTTTIDQRPKFVIDLLHLLREKVENYQVFEGALGTAEQLI-RGQL 1107
            .|     .|||..|||||.|......:.|.:|.|.:..|... |:.:.:|.||...|.|: |...
Human   489 LD-----SDDEFVPYDMSGDRELKSSKAPAYVRDCVEALTTS-EDIERWEAALRALEGLVYRSPT 547

  Fly  1108 AKHDTQLALDLLQLFLVMEMQFYYEQFERTQFKCCVAICVAHPGPCAEYLCRQFHTDNSFYSASV 1172
            |..  :::::|.::.|.:|.:.....|...:.:..||:.|..|.|.|:||..||:..|  ||...
Human   548 ATR--EVSVELAKVLLHLEEKTCVVGFAGLRQRALVAVTVTDPAPVADYLTSQFYALN--YSLRQ 608

  Fly  1173 RILILQVLAATAKELS-----------GDENMQNEMEIVDVIPPAAKHPRKFEFQQEEESPAARL 1226
            |:.||.||...|:|||           |..:..     ...:|.||           ...|.:.:
Human   609 RMDILDVLTLAAQELSRPGCLGRTPQPGSPSPN-----TPCLPEAA-----------VSQPGSAV 657

  Fly  1227 AAAQR-IIRDRLRAKTKRYFSK--PKAGDQMEKANPFHPVAGTFFFSL----------------- 1271
            |:..| ::.:|:|:||:| .||  |:.|.....:. |:.|||.|||.|
Human   658 ASDWRVVVEERIRSKTQR-LSKGGPRQGPAGSPSR-FNSVAGHFFFPLLQRFDRQGASRKIPLWL 720

  Fly  1272 ---VRGQRTRQMLYVKYEN----------------------------------ISHDI---DTQL 1296
               :|.|.:..||.:.:..                                  ::.|:   |..:
Human   721 SFAMRHQASAPMLGLWHGRQCRPHVPDAITCWALLASSCLSRRCTGPTFRAPLVTFDLLGEDQLV 785

  Fly  1297 LVNLLNTMSVLVMCSQNCPLLPAMTREIFDLCAFVRFNAEARVRAATLQLIGIALVTTPAHVLAQ 1361
            |..|.:|:..|:..:.|..:..||.:.:.:....:||:.:|.||...|..:...|::.||..|.:
Human   786 LGRLAHTLGALMCLAVNTTVAVAMGKALLEFVWALRFHIDAYVRQGLLSAVSSVLLSLPAARLLE 850

  Fly  1362 HFAESLNELQRWLNDFIRSPLVGGETSEECRELA 1395
            ...:.|.|.:.||.|....     :..|:||.||
Human   851 DLMDELLEARSWLADVAEK-----DPDEDCRTLA 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lqfR	NP_732736.2	ENTH_epsin	27..150	CDD:239627
		DUF4045	<226..459	CDD:289995
		Telomere_reg-2	1072..1184	CDD:287202	34/112 (30%)
TELO2	XP_011521075.1	Telomere_reg-2	512..620	CDD:287202	34/112 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	60	1.000	Domainoid score	I10612
eggNOG	1	0.900	-	-		E1_KOG4346
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177926at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.780