DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lqfR and ENT1

DIOPT Version :9

Sequence 1:	NP_732736.2	Gene:	lqfR / 42632	FlyBaseID:	FBgn0261279	Length:	1415	Species:	Drosophila melanogaster
Sequence 2:	NP_010120.1	Gene:	ENT1 / 851392	SGDID:	S000002320	Length:	454	Species:	Saccharomyces cerevisiae

Alignment Length:	498	Identity:	112/498 - (22%)
Similarity:	188/498 - (37%)	Gaps:	80/498 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 RELADKVTNVVMNYTETEGKVREATNDDPWGPTGPLMQELAYSTFSYETFPEVMSMLWKRMLQDN 76
            ::......|:|..|:.|:..||.||::|....:...:.|||..::....|.|:|.||.|| |.|.
Yeast     3 KQFVRSAKNLVKGYSSTQVLVRNATSNDNHQVSKDSLIELAEKSYDSADFFEIMDMLDKR-LNDK 66

  Fly    77 KTNWRRTYKSLLLLNYLVRNGSERVVTSSREHIYDLRSLENYTFTDEGGKDQGINVRHKVRELID 141
            ...||...|:|.:::||:|.|||..|...||::|.:::|:.:...|:.|.|||..||.|.:||..
Yeast    67 GKYWRHIAKALTVIDYLIRFGSENCVLWCRENLYIIKTLKEFRHEDDEGIDQGQIVRVKAKELTA 131

  Fly   142 FIQDDDRLREERKKAKKNKDKYIGMSSDAMGMRSGGYSGYSGGSGGGGGGSGGYNDGDYRSSRGD 206
            .:.||:||.|||....|.:::                    .|....|.|....||.|.:.:...
Yeast   132 LLSDDERLNEERNMNIKGRNR--------------------KGRRRRGTGRSDENDDDLQRAISA 176

  Fly   207 NWYSDKSADKDRYEDDDTHYDGEREGSDSDSPSPRRNYRYNDRASPAEVASEAKPSSLNMNIRSK 271
            :..:.:..::.|.:|:|  |:...:.|..:....|..       ....:..:.....|...:...
Yeast   177 SRLTAEEDERRRKQDED--YETALQLSKEEEELKRLQ-------DLQRMQQQQGQQQLQQPMYYD 232

  Fly   272 TVSSPVSKQPTSTASAKPALSQKKIDLGAAAN----FGKP-APGGAAGIHSPTHRDTPTSVDLMG 331
            ...:|::.:..:....:....|::..|.....    ||.| .|...|.............:..|.
Yeast   233 IFGNPITPEEYAQFQLQQQQQQQQQQLQQQPMYYDVFGNPITPEELAQFQQQQQLQEQQYLASMQ 297

  Fly   332 GASPSPSTSKANNNTQSNNNDLLDDLFKTCSP----------PPGQEKTLNSAAVIVDDDDDFNP 386
            ....:.|.:....:.||:::...:.|....||          |..|.:|.|.:  :.|.....|.
Yeast   298 QQQQAMSNNPFAKSEQSSSSPKRNQLVAASSPQQLQQQKQQEPLIQNRTGNQS--MTDKYSKLNE 360

  Fly   387 -RASDASQQEFGDFASAFGQPSAGSTISEPPSTGLVPAANDEFADFAAFQGSTTSTSALDGNLLK 450
             .|:......||:...|                 .:||.:.:...|...||:        |....
Yeast   361 LLATGTGIDTFGNVGEA-----------------RIPAQHTKTGTFINSQGT--------GYRQV 400

  Fly   451 TATPANDSFDLFNSAPT---STAAATTATDLLAGLGDLSIHQS 490
            :..|.::.|  .||..|   ||:...|.|..  |.|:.|..||
Yeast   401 SDDPNHNPF--LNSQYTGLPSTSVVPTQTGY--GFGNQSQQQS 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lqfR	NP_732736.2	ENTH_epsin	27..150	CDD:239627	46/122 (38%)
		DUF4045	<226..459	CDD:289995	36/248 (15%)
		Telomere_reg-2	1072..1184	CDD:287202
ENT1	NP_010120.1	ENTH_Ent1_Ent2	15..146	CDD:340788	51/131 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2102
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940