DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lqfR and epn3a

DIOPT Version :9

Sequence 1:	NP_732736.2	Gene:	lqfR / 42632	FlyBaseID:	FBgn0261279	Length:	1415	Species:	Drosophila melanogaster
Sequence 2:	XP_009298027.1	Gene:	epn3a / 794862	ZFINID:	ZDB-GENE-131121-324	Length:	645	Species:	Danio rerio

Alignment Length:	768	Identity:	193/768 - (25%)
Similarity:	296/768 - (38%)	Gaps:	196/768 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LADKVTNVVMNYTETEGKVREATNDDPWGPTGPLMQELAYSTFSYETFPEVMSMLWKRMLQDNKT 78
            |..:|.|:|.|||:.|.||||||::|||||...||.|::..||:...|.|||.::||| |.|:..
Zfish     6 LRRQVKNIVNNYTDAEIKVREATSNDPWGPPSSLMMEISDLTFNVVAFTEVMGIIWKR-LNDHGK 69

  Fly    79 NWRRTYKSLLLLNYLVRNGSERVVTSSREHIYDLRSLENYTFTDEGGKDQGINVRHKVRELIDFI 143
            |||..||:|.||.||::.|||||....:|:||.:::|.::.:.|..|:|||::||.|.::|:..:
Zfish    70 NWRHVYKALNLLEYLIKTGSERVAQQCKENIYAIQTLRDFQYIDRDGQDQGMSVREKSKQLVALL 134

  Fly   144 QDDDRLREERKKAKKNKDKYIGMSSDAMGMRS--GGYSGYSGGSGGGGGGSGGYNDGDYRSSRGD 206
            :||:||::||.:|.|.:::..| |:.|||..|  ..|.|                       |..
Zfish   135 RDDERLKQERSQAHKTRERVTG-STSAMGYGSLPPPYPG-----------------------RHP 175

  Fly   207 NWYSDKSADKDRY---EDDDTHYDGEREGSDSDSPSPRRNYRYNDRASPAEVASEAKPSSLNMNI 268
            :..|.::...|.:   .|....::     |.|.||....:.   :||.|.....|.....|.:.:
Zfish   176 SQPSMQAVHVDEFARPRDSPASFN-----SSSSSPHLAPDL---ERARPQTSGEEELQLQLALAM 232

  Fly   269 ---RSKTVSSPVSKQPTSTASAKPALS-QKKIDLGAAANFGKPAPGGAAGIHSPTHRDTPTSVDL 329
               .|:.....|..|||      ||:. .::..|..|.:..|          ..||:.||
Zfish   233 SREESEKTHESVLPQPT------PAVDIDEQTQLQIAMSLSK----------EETHKPTP----- 276

  Fly   330 MGGASPSPST-----------------SKANNNTQSNNNDLLDDLFKTCSPPPGQEKTLNSAAVI 377
            :....|.|:.                 ||..:..:..:....:.|.:.......:|......:.:
Zfish   277 LPPPPPPPAAAVMEMDEEAQLQLALTLSKEEHQQEERSRRGDESLLQKALEESKREMEAKGGSAM 341

  Fly   378 VDDDDDFN-----PRASDASQQEFGDFASAFGQPSAGSTISEP-----PSTGL--------VPAA 424
            :|..|.|.     |.|:.|.....|..|.|    .||...|:|     ||:.:        .|.|
Zfish   342 LDLADIFTSAPELPSAASAWDSSGGQGALA----QAGPLRSDPWDSLEPSSSIRRHGSSWNAPPA 402

  Fly   425 NDEFADFAAFQGSTTSTSALDGNLLKTATPANDSFDLFNSAPTSTAAATTATDLLAGLGDLSIHQ 489
            :.|::...|.:..|:.         ....|.|      .|:|.||.....:....||:...|
Zfish   403 SSEYSQPWAHRQQTSD---------PWDAPQN------ASSPVSTNHTWISPAHGAGVDPFS--- 449

  Fly   490 SMPMAVEEQLASSNDSMSSASPQPPSEAMRLAFSKAQKQLRDLMQVQSASAVAQVAAILGELHNS 554
              |..|:.:     .|:......||.     |.|.:...|.|             .|:.|...|.
Zfish   450 --PPVVDRR-----GSIGPLKTSPPR-----AGSPSDDDLFD-------------EAMDGGQANV 489

  Fly   555 NALPGFTTPEQL------VGLDR---QTCDWTCLAHGEYAALLNQLTELFSQDWPEPSQDVEVVN 610
            |   |..:||..      .||.:   :||.......|...|.|..|..|..   |.|:.  :..|
Zfish   490 N---GHGSPEPFNLSSLGEGLPKPAPRTCSTPEAFLGPSGASLVNLDSLIP---PNPTS--KNFN 546

  Fly   611 IFKLDHSFDYVSVAFESLQTRL---DKFPSTISSLLENMVKDESLISIALLHISRQRASLMQRFA 672
            .|.........|..|::...||   ...||:.|....::..:.||...:    |:|.:||...|.
Zfish   547 PFLSGVPAPTTSNPFQNEAPRLTLNQMRPSSTSPAPSSLPFNASLAMAS----SQQPSSLPNTFT 607

  Fly   673 RTIKVMPERKVEELDAQVKAFFQLLISLPAQVANRLGRRLPETFAPVSYQKLL 725
            ::.:|||                 ||..|          ||:...|:|.:.:|
Zfish   608 QSAQVMP-----------------LIPGP----------LPQPLLPLSSKTML 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lqfR	NP_732736.2	ENTH_epsin	27..150	CDD:239627	57/122 (47%)
		DUF4045	<226..459	CDD:289995	51/271 (19%)
		Telomere_reg-2	1072..1184	CDD:287202
epn3a	XP_009298027.1	ENTH_epsin	19..141	CDD:239627	57/122 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2102
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940