DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lqfR and telo2

DIOPT Version :9

Sequence 1:	NP_732736.2	Gene:	lqfR / 42632	FlyBaseID:	FBgn0261279	Length:	1415	Species:	Drosophila melanogaster
Sequence 2:	NP_001071209.1	Gene:	telo2 / 777634	ZFINID:	ZDB-GENE-061103-523	Length:	822	Species:	Danio rerio

Alignment Length:	877	Identity:	215/877 - (24%)
Similarity:	354/877 - (40%)	Gaps:	166/877 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   578 CLAHGEYAAL-----LNQLTELFSQDWPEPSQDVEVVNIFKLDHSFDYVSVAFESLQTRLDKFPS 637
            ||..||:..:     |..|....|..|...|.|.:...:.||.........|.::|.|.||
Zfish    40 CLDDGEFTRIHHTHALQVLVSAQSSHWFSRSHDEDEEEMKKLWGEIIIRGPAEQTLLTLLD---- 100

  Fly   638 TISSLLENMVKD------ESLISIALLHI---SRQRA----SLMQRFARTIKVMPERKVEELDAQ 689
            ||||..|:...|      |..:|.|.|.:   ||..|    |...:...|:
Zfish   101 TISSTGESEALDRCVSALEMFLSAARLQVLLWSRCEAGGASSDSPQLTETV-------------- 151

  Fly   690 VKAFFQLLISLPAQVANRLGRRLPETFAPVSYQKLLLRQWLKSLHFVLQCDDNREYFDLEPYSWL 754
                ...|.:||:..:|.|....|:.|.|..|..||....|.:|.  ..|...|...|..  ...
Zfish   152 ----IGHLAALPSITSNHLHTNTPDIFLPQQYYPLLAASILDTLE--KTCHALRAGRDCS--LGF 208

  Fly   755 LSQAINLI----YDVSTLES----LLRVLKDYAVAPRGRKVVHTILKELDPAACLKTAQS----A 807
            :||.:..:    |.....|:    |..|.::.|:..|   |...:|:.: |..|.::..:    :
Zfish   209 VSQVLGKVCIQGYSSQMFETLGPRLSSVTREDALYQR---VTQKLLENV-PERCTESVITGLIRS 269

  Fly   808 LSAGLNLYVLIGAATLETPHWKHCLLQKLPLQRTPVDNKQLITLASYLNAVAPAQ---LQVLLNQ 869
            ||....:..|:|...|.....:..|..||.||:.....:.|.::..|| ||..::   |:.:|..
Zfish   270 LSGAAAVSRLMGNLVLTNKKAQFVLTHKLILQQYQHPTRLLKSVLGYL-AVDSSRRPLLKQVLRS 333

  Fly   870 LLGIWSKRISLQKLGSQEHLAISKLLVLAAKCLCGNLVMDLNIQ--RQ-----LHDGLSNHLQSP 927
            :..:|....:::....::.|.:||.|:     ||..|:.|..||  ||     :..|:...|.|.
Zfish   334 VCQVWCNSSAVKHTCVEQQLYVSKALL-----LCVALLDDSEIQELRQEMLQCMLGGVQCRLDSN 393

  Fly   928 DALQRHVGMKTVELIFNFIALPDAKEDDRLRFEYDSFKDTFHWHIFEEFDELGQFESPSKTKLDE 992
            ....|.:||...|.:.:.:..|.:    :|:|:|.:            .:|:|:.:|
Zfish   394 VERIRRMGMVVGECLSHRLDTPGS----QLKFQYGA------------DEEIGELKS-------- 434

  Fly   993 KPCEDQLKQLELHLSDFMSTTEQKEPHKPNIEIQANPAPE------NQNVNMQLDSDDDEPLDED 1051
                         |.:.::..:.:| .:|:......|.|:      :|:|.....:..:..||.|
Zfish   435 -------------LMESLAVNDDEE-EQPDASHSLQPEPKVEASVLSQSVASDPGNGSESELDSD 485

  Fly  1052 DDELKPYDMSNDTTTTIDQRPKFVIDLLHLLREKVENYQVFEGALGTAEQLIRGQLAKHDTQLAL 1116
            || |.|||||.|........|.:|.|.|..|... ::.:.||.:|..||.|:|..| |...::::
Zfish   486 DD-LTPYDMSADQEKKKSAPPCYVRDCLEGLMSS-DDAERFELSLQVAETLLRKNL-KATQEVSV 547

  Fly  1117 DLLQLFLVMEMQFYYEQFERTQFKCCVAICVAHPGPCAEYLCRQFHTDNSFYSASVRILILQVLA 1181
            ...::.|.:|.::....|...:....||:.|....|..:|...:|:..|  ||...|:.||:|||
Zfish   548 QFSKVLLHLEDRYNTALFLSLRQNAMVALTVTDIKPVVDYWTTEFYALN--YSLRQRLDILEVLA 610

  Fly  1182 ATAKELSGDENMQNE---MEIVDVIPPAAKHPRKFEFQQEEESPAARLAAAQRIIRDRLRAKTKR 1243
            ..|:|||  |.:.|:   .|.:..:.|..:......::|              |:..|:::||:|
Zfish   611 LAAQELS--EPLTNKHTGAEPITAVTPLGQSDDITHWRQ--------------IVDKRIQSKTRR 659

  Fly  1244 YFSKPKAGDQMEKA--NPFHPVAGTFFFSLVRGQRTRQMLYVKYENISHDI---DTQLLVNLLNT 1303
            .   .|...|..||  |.:.||||.|||.|:|.....|..:        |:   |..:|..||:|
Zfish   660 I---SKGVTQPVKAVPNRYAPVAGFFFFPLLRSYDRPQTTF--------DLLGGDHLVLGRLLHT 713

  Fly  1304 MSVLVMCSQNCPLLPAMTREIFDLCAFVRFNAEARVRAATLQLIGIALVTTPAHVLAQHFAESLN 1368
            :.:|:..:.|.|::..|.|.:.|....|||:.:..||...:..:....::.|:..|.....:.|.
Zfish   714 LGLLMHLAVNAPVVSQMGRALLDFVWAVRFHTDQMVRRGVMFAVCAVFLSMPSENLLTELGDDLM 778

  Fly  1369 ELQRWLNDFIRSPLVGGETSEECRELA-QSIL 1399
            |.:.||.|...|     :...:||.|| ||::
Zfish   779 ETRAWLADVAES-----DCDSDCRSLAVQSLM 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lqfR	NP_732736.2	ENTH_epsin	27..150	CDD:239627
		DUF4045	<226..459	CDD:289995
		Telomere_reg-2	1072..1184	CDD:287202	32/111 (29%)
telo2	NP_001071209.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	442..504		18/63 (29%)
telo2	NP_001071209.1	Telomere_reg-2	505..613	CDD:287202	32/111 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I10291
eggNOG	1	0.900	-	-		E1_KOG4346
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I4593
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177926at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.870