DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lqfR and epn2

DIOPT Version :9

Sequence 1:	NP_732736.2	Gene:	lqfR / 42632	FlyBaseID:	FBgn0261279	Length:	1415	Species:	Drosophila melanogaster
Sequence 2:	NP_001006853.1	Gene:	epn2 / 448609	XenbaseID:	XB-GENE-22060525	Length:	579	Species:	Xenopus tropicalis

Alignment Length:	585	Identity:	171/585 - (29%)
Similarity:	272/585 - (46%)	Gaps:	95/585 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 KVTNVVMNYTETEGKVREATNDDPWGPTGPLMQELAYSTFSYETFPEVMSMLWKRMLQDNKTNWR 81
            ::.|:|.||:|.|.||||||::|||||:..||.|:|..|::...|.|:|||:||| |.|:..|||
Frog     9 QMKNIVNNYSEAEIKVREATSNDPWGPSSSLMTEIADLTYNVVAFSEIMSMIWKR-LNDHGKNWR 72

  Fly    82 RTYKSLLLLNYLVRNGSERVVTSSREHIYDLRSLENYTFTDEGGKDQGINVRHKVRELIDFIQDD 146
            ..||:|.||:||::.|||||....:|:|:.:::|:::.:.|..|||||||||.|.::|:..::||
Frog    73 HVYKALTLLDYLIKTGSERVSHQCKENIFAIQTLKDFQYMDRDGKDQGINVREKSKQLVCLLKDD 137

  Fly   147 DRLREERKKAKKNKDKYIGMSSDAMGMRSGGYSGYSGGSGGGGGGSGGYNDGDYRSSRGDNWYSD 211
            :||:.||.:|.|.|::   |:..|.|:.|.....:..|| .....|..|::.||..|.|
Frog   138 ERLKGERAQALKTKER---MAQVATGVSSNNQITFGRGS-SQPNLSTSYSEQDYGKSGG------ 192

  Fly   212 KSADKDRYEDDDTHYDGE---REGSDSDSPSPRRNYRYNDR-----ASPAEVASEAKPSSLNMNI 268
                      ....|.|.   |..|:.:...|:.:.....:     |...|||.:.:......::
Frog   193 ----------SPASYHGSTSPRVSSELEQARPQTSGEEELQLQLALAMSREVAEQEERIRRGDDL 247

  Fly   269 RSKTVSSPVSKQPTSTASAKPALSQKK-IDLGAAANFGKPAP----GGAAGIHSPTHRDTPTSVD 328
            |.: ::...|::.|..|..|.|..|.. :||..|...|.|||    ..||.:.:.:..| |.:|
Frog   248 RLQ-MALEESRKHTIKAPRKKAQQQTTLLDLLDALPSGAPAPQKPDTWAAAVATKSKSD-PWNV- 309

  Fly   329 LMGGASPSPSTSKANNNTQSNNNDLLDDLFKTCSP--PPGQEKTLNSAAVIVDDDDDFNPRAS-- 389
                |:.|||:|....:..|..        ||.:|  |.|.:...::.::..:.|....|:|:
Frog   310 ----AAVSPSSSDPWQSFGSGT--------KTAAPQDPWGGKAGPSTQSLSKNSDPWSTPKAAGI 362

  Fly   390 --------DASQQEFGDFASAFGQPSAGSTISEPPSTGLVPAANDEFADFAAFQGSTTSTSALDG 446
                    .|:.|...:.::|.|       ::..|.:.|...|.|:.::|.:.:  |:|..:.|.
Frog   363 ASSPTDPWGATPQVKANMSNAGG-------LAFDPFSNLNGTAKDDLSEFDSLR--TSSKVSADS 418

  Fly   447 N-LLKTATPANDSFDLFNSAPTS------TAAATTATDLL---AGLGDLSIHQSMP----MAVEE 497
            | .|.:......|.|||.|.|.:      |:...|....|   |.|.:|....|||    ..:..
Frog   419 NSTLPSLRSGTTSPDLFASKPDNVTSSKQTSVRKTPESFLGSNAALVNLETLVSMPPPAAPILNP 483

  Fly   498 QLASSNDSMSSASPQPPSEAMRLAFSKAQKQLRDLMQVQSASAVAQVAAILGELHNSNALPGFTT 562
            .|||...:.::..|..|       |...|.|...|.|::|:..:...|..|    :|...||.:|
Frog   484 FLASGAATTTTTPPVNP-------FQVNQPQALTLNQLRSSPMMGAGAEPL----SSVPPPGMST 537

Fly 563 562
Frog 538 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lqfR	NP_732736.2	ENTH_epsin	27..150	CDD:239627	61/122 (50%)
		DUF4045	<226..459	CDD:289995	56/258 (22%)
		Telomere_reg-2	1072..1184	CDD:287202
epn2	NP_001006853.1	ENTH_Epsin	19..141	CDD:340787	61/122 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2102
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940