DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lqfR and clint1a

DIOPT Version :9

Sequence 1:	NP_732736.2	Gene:	lqfR / 42632	FlyBaseID:	FBgn0261279	Length:	1415	Species:	Drosophila melanogaster
Sequence 2:	NP_001003412.1	Gene:	clint1a / 323870	ZFINID:	ZDB-GENE-030131-2590	Length:	633	Species:	Danio rerio

Alignment Length:	557	Identity:	225/557 - (40%)
Similarity:	294/557 - (52%)	Gaps:	118/557 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ISMWKVRELADKVTNVVMNYTETEGKVREATNDDPWGPTGPLMQELAYSTFSYETFPEVMSMLWK 70
            ::|||||||.||.|||||||||||.|||||||||||||:|.||.|:|..||.||.|||||:|||.
Zfish     2 LNMWKVRELVDKATNVVMNYTETESKVREATNDDPWGPSGQLMGEIARCTFMYEQFPEVMNMLWT 66

  Fly    71 RMLQDNKTNWRRTYKSLLLLNYLVRNGSERVVTSSREHIYDLRSLENYTFTDEGGKDQGINVRHK 135
            |||:|||.||||.|||||||.||:||||||||||:|||:|||||:|:|...||.|||||:|||.|
Zfish    67 RMLKDNKKNWRRVYKSLLLLAYLIRNGSERVVTSAREHLYDLRSIESYHCVDENGKDQGVNVRQK 131

  Fly   136 VRELIDFIQDDDRLREERKKAKKNKDKYIGMSSDAM-GMRSGGYSGYSGGSGGGGGGSGGYNDGD 199
            |:|||:|:||||||||||||||||:|||||:|||:| |.|      ||         ...::..:
Zfish   132 VKELIEFVQDDDRLREERKKAKKNRDKYIGVSSDSMSGFR------YS---------EDRFDSRE 181

  Fly   200 YRSSRGDNWYSDKSA-----------DKDRYEDDDT---HYDGEREGSD---SDSPSPRRNYRYN 247
            .||...|:|..:|.|           ||.....|||   ....:||.|.   |::...||..| |
Zfish   182 PRSKWDDDWEKNKGAFPFSEKLGEISDKIGSTIDDTINMFRKKDREDSPDRFSEADEERRGTR-N 245

  Fly   248 DRASPAEVASEAKPSSLNMNIRSKTVSSPVSKQPTSTASAKPALSQKKIDLGAAANFGKPAPGGA 312
            .::..:|...:.:      .:.:|:|.  :.:...:||:.|..:..|.|||||||::    .|..
Zfish   246 GQSGKSEFKDDEE------TVTTKSVQ--IVQATETTATRKKGVPSKTIDLGAAAHY----TGDK 298

  Fly   313 AGIHSPTHRDTPTSVDLMGGASPSPSTSKANNNTQSNNNDLLDDLFKTCSPPPGQEKTLNSAAVI 377
            :..:|.|::.|.||      |...||:.             |.||| :..|.|.|
Zfish   299 SSNNSNTNQTTTTS------AVSQPSSG-------------LVDLF-SADPAPAQ---------- 333

  Fly   378 VDDDDDFNPRASDASQQEFGDFASAFGQPSAGSTISEPPSTGLVPAAN-DEFADFAAFQGSTTST 441
                    |.:...|....|.||. |..|:|.:::  |.||....:.| .:|.|:.||..:..:.
Zfish   334 --------PASKGLSSDLIGGFAD-FSSPAAAASL--PSSTAPASSGNGGDFGDWNAFPAAQQAV 387

  Fly   442 SALDGNLLKTATPANDS-FDLFNS-------APTSTAAATTATDLLAG--LGDLSIHQSM--PMA 494
            .|        |.|.|.: .|||:.       ||.|||.::...||:..  ..:.|..||:  .|.
Zfish   388 PA--------AQPVNPAGIDLFSGFQTAPAPAPVSTAPSSDLFDLMGSSQTTNFSTSQSLNFSMT 444

  Fly   495 VEEQL----ASSNDSMSSASPQPPSEAMRLAFSKAQK 527
            ..:.:    :.|..|.:...|..|.:.|      |||
Zfish   445 TSQTIGMPTSKSQPSQTMGVPLMPQQPM------AQK 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lqfR	NP_732736.2	ENTH_epsin	27..150	CDD:239627	93/122 (76%)
		DUF4045	<226..459	CDD:289995	58/237 (24%)
		Telomere_reg-2	1072..1184	CDD:287202
clint1a	NP_001003412.1	ENTH_epsin	23..146	CDD:239627	93/122 (76%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574746
Domainoid	1	1.000	210	1.000	Domainoid score	I2763
eggNOG	1	0.900	-	-		E1_KOG2057
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H133740
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005493
OrthoInspector	1	1.000	-	-		otm25397
orthoMCL	1	0.900	-	-		OOG6_103183
Panther	1	1.100	-	-	LDO	PTHR12276
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.740