DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lqfR and ent1

DIOPT Version :9

Sequence 1:	NP_732736.2	Gene:	lqfR / 42632	FlyBaseID:	FBgn0261279	Length:	1415	Species:	Drosophila melanogaster
Sequence 2:	NP_588237.1	Gene:	ent1 / 2539390	PomBaseID:	SPCC162.07	Length:	706	Species:	Schizosaccharomyces pombe

Alignment Length:	708	Identity:	165/708 - (23%)
Similarity:	258/708 - (36%)	Gaps:	160/708 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 NVVMNYTETEGKVREATNDDPWGPTGPLMQELAYSTFSYETFPEVMSMLWKRMLQDNKTNWRRTY 84
            |....||:|:.|||.||.:|.|||:|..|.|:|..|:......|||.:: .|.|.|...|||..:
pombe    14 NFSKGYTDTQIKVRNATTNDSWGPSGTAMAEIAELTYDQNEMLEVMDII-DRRLNDKGKNWRHVF 77

  Fly    85 KSLLLLNYLVRNGSERVVTSSREHIYDLRSLENYTFTDEGGKDQGINVRHKVRELIDFIQDDDRL 149
            |||.||.|.:.||||.||..::::||.:.:|..:.:.|:.|.|||.|||.|.:|:...::|:..|
pombe    78 KSLSLLEYCLHNGSENVVRWAKDNIYIITTLREFVYVDDNGHDQGQNVRTKAKEITSLLEDEHAL 142

  Fly   150 REERKKAKKNKDKYIGMSSDAMGMRSGGYSGYSGGSGGGGGGSGGYNDGDYRSSRGDNWYSDKSA 214
            :|.|..::: :|:      |....||..:.                :|.|.|:...::..|...:
pombe   143 KEARGDSRE-RDR------DRDRTRSSRFD----------------DDDDDRAPYEESRLSRAPS 184

  Fly   215 DKDRYEDDDTHYDGEREGSDSDSPSPRRNYRYNDRASPA---EVASEAKPSSLNMNIRSKTVSSP 276
            ...||:|||..:...|. |.|..|...|:.|.:.|.||:   ..|.|..|....:...||..:..
pombe   185 RASRYDDDDRDHRSRRR-SRSRRPGRSRSRRRSRRPSPSAEHNSAEENDPELQRVIEESKRQAEE 248

  Fly   277 VSKQPTSTASAKPALSQKKIDLGAAANFGKPA------------PGGAAGIHSPTHRDTPTSVDL 329
            .:|: .:.|:...|..||.|.|....:..:..            .|.....:.|        ||.
pombe   249 DAKR-RNMANDSEAELQKAIQLSKEEDEARQRHQREREQQEQAFMGNQQNAYQP--------VDF 304

  Fly   330 MGGASPSPSTSKANNNTQSNNNDLLDDLFKTCSPPPGQEKTLNSAAV-------IVDDDDDF-NP 386
            .|            |..|......|.      ..|.|..:..|:..|       :......| .|
pombe   305 FG------------NPVQPQPTGFLQ------QQPTGFIRPQNTGFVQPQYTGFVQPQHTGFVQP 351

  Fly   387 RASDASQQEFGDF----ASAFGQPSAGSTISEPPSTGLVPAANDEFAD-------------FAAF 434
            :|:...|.:...|    |:.|.||.|...: :|.:||.:......|..             |...
pombe   352 QATGFMQPQRTGFVQPQATGFVQPQATGFV-QPQATGFMQPQRTGFVQPQATGFMQPQRTGFVQP 415

  Fly   435 QGSTTSTSALDGNLLKTAT------------PANDSFDLFNSAPTSTAAATTATDLLAGLGDLSI 487
            |.:........|.:...||            |..:.|  ||..||               |.:..
pombe   416 QATGFMQPQRTGFVQPQATGFIQPQRTGFVQPQQNGF--FNPQPT---------------GYMQP 463

  Fly   488 HQSMPMAVEEQLASSNDSMSSASPQPPSEAMRLAFSKAQKQLRDLMQVQSASAVAQVAAILGELH 552
            .::..|  :.|....:....|.:|.|..:..|..|.:...                 |.::...|
pombe   464 QRTGMM--QPQRTGFSQPFESNNPFPVMQPQRTGFGQTPN-----------------APMMAPNH 509

  Fly   553 NSNALPGFTTPEQLVGLDRQTCDWTCLAHGEYAALLNQLTELFSQDWPEPSQDVEVV-----NIF 612
            .     |:..| |..||.|||..:|...:.....|.:|.|.:..|...:.:..:|..     |.|
pombe   510 T-----GYVHP-QPTGLQRQTTGYTGNNNPYSRPLQSQSTGILQQQQQQSAPRLEPTKTGSNNPF 568

  Fly   613 KLDHSFDYVSVA-----FESLQTRLDKFPSTISSLLE--NMVKDESLISIALLHISRQ 663
            ....:....|.|     .:.::|..|:| |.|:..:.  |.:..:|..:|.|..:..|
pombe   569 AQFSNLPSQSTAPATKPMKPVRTGDDRF-SNIAQAISTGNPMGTDSFGNIGLTRVPTQ 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lqfR	NP_732736.2	ENTH_epsin	27..150	CDD:239627	50/122 (41%)
		DUF4045	<226..459	CDD:289995	53/284 (19%)
		Telomere_reg-2	1072..1184	CDD:287202
ent1	NP_588237.1	ENTH_epsin	21..143	CDD:239627	50/122 (41%)
		DUF1151	<230..289	CDD:284125	11/59 (19%)
		MAP7	<234..>289	CDD:283355	9/55 (16%)
		DUF1720	309..380	CDD:285440	16/76 (21%)
		DUF1720	349..428	CDD:285440	15/79 (19%)
		DUF1720	389..476	CDD:285440	15/105 (14%)
		DUF1720	438..527	CDD:285440	24/130 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2102
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940