DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lqfR and clk-2

DIOPT Version :9

Sequence 1:	NP_732736.2	Gene:	lqfR / 42632	FlyBaseID:	FBgn0261279	Length:	1415	Species:	Drosophila melanogaster
Sequence 2:	NP_001370399.1	Gene:	clk-2 / 176065	WormBaseID:	WBGene00000537	Length:	877	Species:	Caenorhabditis elegans

Alignment Length:	842	Identity:	179/842 - (21%)
Similarity:	312/842 - (37%)	Gaps:	144/842 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   617 SFDYVSVAFESLQTRLD--------KFPSTISSLLENMVKDESLISIALLHISRQRASLMQRFAR 673
            |.|..:..|..:.|.||        ...|.|.|.|:  ||:..:.::          .|.:.||.
Worm    81 STDINTTTFRDVITMLDWLKYVVEKSLTSAICSSLK--VKETDVSAV----------QLYREFAS 133

  Fly   674 TIKVMPERKVEELDAQ------------VKAFFQLLISLPAQVANRLGRRLPETFAPVSYQKLLL 726
            ....:|| ||....|:            ||..|::.:....|.|..|......|.||.:......
Worm   134 ACSNIPE-KVSNCCAKALSGEHVKYINTVKWIFKMNLVQGIQKAMLLAHDDIVTAAPFTSFYGSG 197

  Fly   727 RQWLKSLHFVLQCDDNREYFDLEPYSWLLSQAINLIYDVSTLESLLRVLKDYAVAPRGRKVVHTI 791
            ..::|::..::....|   .|:.....||.|.|..|..::..:|            :.|:::..|
Worm   198 GPYMKTVAEIISSGRN---IDITNKDGLLVQMIEWIGSLNNFDS------------QWRRMMFLI 247

  Fly   792 LKE-----LDPAACLKTAQSALSAGLNLYVLIGAATLETPHWKHCLLQKLPLQRTPVDNKQLITL 851
            .:|     :.....|.|....:|....:......||..|...|..::.|||.||. :..|.:..|
Worm   248 FQEPTYQGIQVHESLLTTLFLISKSDQILKRCIEATDLTGTLKRVVMVKLPFQRV-LKRKTIEIL 311

  Fly   852 ASYLNAVAPAQLQVLLNQLLGIWSKRISLQKLG--SQEHLAISKLLVLAAKC-LCGNLVMDLNIQ 913
            .:::..........||...:.|||. ::..|..  |||...:..:|.|.... .|.::
Worm   312 INFVYRTKEQFAIQLLETSVKIWSD-LNYAKSAPESQERHIVRMILYLVHLFRTCSSI------- 368

  Fly   914 RQLHDGLSNHLQSPDALQRHVGMKTVEL---IFNFIAL------------------PDAKEDDRL 957
                |..|..|.|.|.:...:.|..:.:   ||...||                  |:..|:::
Worm   369 ----DWESLFLNSMDGVHCRMSMLPMYVQSGIFVNQALCKQATKHRSKTHGSDEQPPETLEENK- 428

  Fly   958 RFEYDSFKDTFHWHIFEEFDELGQFESPSKTKLDEKPCEDQLKQLELHLSDFMSTTEQKEPHKPN 1022
               :.|.:....|  |||...:.:....|.|..|    .:::::....::...|..|.:|.:...
Worm   429 ---FVSSEVGKIW--FEEMTSILEHGFNSSTVKD----SERVRETANEITKDDSGEEFEETNAQR 484

  Fly  1023 IEIQANPAPENQNVNMQLDSDDDE-----PLDEDDDELKPYDMSNDTTTTIDQRPKFVIDLLHLL 1082
            ::...:.|......|::|||||||     .::|.:...|..::..:....:.. |.::.|...:|
Worm   485 LQNNKDSAAITSKNNLRLDSDDDEDFPDYQVNESEKIFKNLEIGEEPKNKVTP-PAYIADAFEML 548

  Fly  1083 REKVENYQVFEGALGTAEQLIRGQLAKHDTQLALDLLQLFLVMEMQFYYEQFERTQFKCCVAICV 1147
            .|| |.|:|||.|......||..:.... .|:|..|....|.::..|...:|:.|..:..|| |:
Worm   549 LEK-EKYEVFEAAFFNITNLINRRPIGF-PQIAEKLFIRILHLQNNFGTPKFKETVDEIAVA-CI 610

  Fly  1148 AHPGPCAEYLCRQFHTDNSFYSASVRIL-----ILQVLAATAKELSGDENMQNEMEIVDVIPPAA 1207
            .........:.|........:|...|:|     ....:.|..|:|. :..|..::.|........
Worm   611 TQRPEIVPSVVRLIIAPGQGFSIKQRLLHYIHNAADGMGALDKKLE-ECVMAQQLRIGGPTLSII 674

  Fly  1208 KHPR-KFEFQQEEESPAARLAAA-QRIIRDRLRAKTKRYFS---KPKAGDQMEKANPFHPVAGTF 1267
            .|.. ..::..|:|.|...|... :|::..|:.|.|:|..:   .|:||    ..|.....|...
Worm   675 LHRTINTDYDDEDEDPHRLLVPEWRRMVDARIAANTRRIGTTREPPRAG----VVNRLAQAAKYM 735

  Fly  1268 FFSLV---RGQRTRQMLYVKYENISHDIDTQLLVNLLNTMSVLVMCSQNCPLLPAMTREIFDLCA 1329
            |:.|:   ||:....:          ..|:.||.:|:...|::.:....||.:..|:.|:.....
Worm   736 FYPLLVLPRGENASLL----------GKDSDLLASLIMVASMVYVRCGVCPQIHRMSSELISYAT 790

  Fly  1330 FVRFNAEARVRAATLQLIGIALVTT--PAHVLAQHFAESLNELQRWLNDFIRSPLVGGETSE 1389
            ..||:..|::|.|.  :|....|||  |..::.:.|  .:..|..|. |:..|.||...:|:
Worm   791 PHRFSENAKLRTAC--IIAHLNVTTLLPGDLMDELF--DVPALIGWF-DWANSVLVNASSSQ 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lqfR	NP_732736.2	ENTH_epsin	27..150	CDD:239627
		DUF4045	<226..459	CDD:289995
		Telomere_reg-2	1072..1184	CDD:287202	28/116 (24%)
clk-2	NP_001370399.1	Telomere_reg-2	538..645	CDD:401998	27/109 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4346
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.860