DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13850 and FASTKD1

DIOPT Version :9

Sequence 1:	NP_001262834.1	Gene:	CG13850 / 42630	FlyBaseID:	FBgn0038961	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001308975.1	Gene:	FASTKD1 / 79675	HGNCID:	26150	Length:	847	Species:	Homo sapiens

Alignment Length:	745	Identity:	146/745 - (19%)
Similarity:	235/745 - (31%)	Gaps:	275/745 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 EARAPAVEEAAKKPRGHMVAAAFESLRNDDPKDESKSQASSKIDERIINAKTVNGLLTITENN-- 107
            ||..|.||.        :|..|:..|...|.|..|:. :|...|:.:..:..:..:..|...|
Human   130 EAHDPLVEA--------LVTEAWRRLERFDIKLLSEF-SSCLADQHLYFSPLMGKIADIVHRNLE 185

  Fly   108 --NGFSRKHAL--RIVSILAE-------------WSTLNRVKISEFENDTRFLRICRMLGRTVPK 155
              ...|....|  .|.|:::.             :.|::..:::..::..:|||..|.  |..|.
Human   186 TTQDLSSLSVLMVNISSLISRHFQQQLVNKTELLFDTIDSSEVNVAKSIAKFLRNVRY--RYQPL 248

  Fly   156 NNNANNKDLGDNGTAKRISGFRTDDLNTVLGV-------------AGDDEAAKLIASISLP-QMV 206
            ....||..|.:      :.....|.::.:|.|             ....:..::|...:.| ..|
Human   249 LERCNNVFLSN------VDHLDLDSISKILSVYKFLQFNSFEFIIMAKKKLTEMIPLCNHPASFV 307

  Fly   207 KVMSTLA-------QRKRRSTPLLRSLAFNISSASESLDLKQAGDVLFAMSTLNFQDSVLGAKVC 264
            |:...|.       :::.:||.||         .||.|..:||..||.||..:..::|.|..:
Human   308 KLFVALGPIAGPEEKKQLKSTMLL---------MSEDLTGEQALAVLGAMGDMESRNSCLIKR-- 361

  Fly   265 ADVQSALPKNVE--KSAVVGSIITSLGILRYRDLDILESLTQWL---LKNSEICRPQDLSAYFLT 324
              |.|.|.|:::  |...:..|...|..|.::..:....|.:.|   ||||.|  |.::|.  |.
Human   362 --VTSVLHKHLDGYKPLELLKITQELTFLHFQRKEFFAKLRELLLSYLKNSFI--PTEVSV--LV 420

  Fly   325 SALLNFKSAQLEEVSKKLVKSIVRE-DFTKQSEWLSFV--W--------------SLTMLGLVEH 372
            .|:....|..|:||....:::::.: |....|.:.:.|  |              .|.:|..::|
Human   421 RAISLLPSPHLDEVGISRIEAVLPQCDLNNLSSFATSVLRWIQHDHMYLDNMTAKQLKLLQKLDH 485

  Fly   373 ---------------------------------------------------GHLASVLSA-DFLE 385
                                                               |.:||.:|: |:|.
Human   486 YGRQRLQHSNSLDLLRKELKSLKGNTFPESLLEEMIATLQHFMDDINYINVGEIASFISSTDYLS 550

  Fly   386 TLKKDKAGVTATSKMR---------------LLN----------------LNSYAQL-------- 411
            ||..|:....|..::.               :||                ||||..:
Human   551 TLLLDRIASVAVQQIEKIHPFTIPAIIRPFSVLNYDPPQRDEFLGTCVQHLNSYLGILDPFILVF 615

  Fly   412 ----IATDYKGP----------------------LLPTDS------------------PVYQVPM 432
                :||....|                      |.|:.|                  |.:|:|.
Human   616 LGFSLATLEYFPEDLLKAIFNIKFLARLDSQLEILSPSRSARVQFHLMELNRSVCLECPEFQIPW 680

  Fly   433 AHPKAKQVL---VNGM-------LDALKSLLPASNHLQTAVDTKMGFLIDALCHFDANKNPLPLD 487
            .|.:..|..   :.||       ...|..:|...|.::.:|.|.....:|..|..|..|.|||..
Human   681 FHDRFCQQYNKGIGGMDGTQQQIFKMLAEVLGGINCVKASVLTPYYHKVDFECILDKRKKPLPYG 745

  Fly   488 KEN-----------------------PNAIRVALMVIDFHDICHG-THRSGSGVTNLTFDLLEKS 528
            ..|                       |.|.|:||..:|...:|.. .|..|........  ||..
Human   746 SHNIALGQLPEMPWESNIEIVGSRLPPGAERIALEFLDSKALCRNIPHMKGKSAMKKRH--LEIL 808

  Fly   529 GYHVIPVPYNEF-----STSDKLLKRVQYL 553
            ||.||.:...|:     ||.|   .|:.||
Human   809 GYRVIQISQFEWNSMALSTKD---ARMDYL 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13850	NP_001262834.1	FAST_1	319..385	CDD:284217	19/134 (14%)
		FAST_2	402..484	CDD:285557	28/159 (18%)
		RAP	498..556	CDD:214932	18/62 (29%)
FASTKD1	NP_001308975.1	FAST_1	575..642	CDD:284217	9/66 (14%)
		FAST_2	662..742	CDD:285557	16/79 (20%)
		RAP	779..838	CDD:214932	18/62 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21228
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010