DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13850 and FASTKD5

DIOPT Version :9

Sequence 1:	NP_001262834.1	Gene:	CG13850 / 42630	FlyBaseID:	FBgn0038961	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_068598.1	Gene:	FASTKD5 / 60493	HGNCID:	25790	Length:	764	Species:	Homo sapiens

Alignment Length:	739	Identity:	138/739 - (18%)
Similarity:	241/739 - (32%)	Gaps:	283/739 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 AAKKPRGHMVAAAFESLR-----NDDPKDESKSQASSK-------------IDERII-------- 92
            :|||.:.  :.:.|.|.|     :..|..|....:|||             :||..:
Human    52 SAKKVKN--ICSTFSSRRILTTSSAHPGLEFSKTSSSKASTLQLGSPRATGVDEEDVEVFDSFEN 114

  Fly    93 ----------------NAKTVNGLLTITE----------NNNGFSRKHALRIVSILAEWSTLNRV 131
                            ||...:.||:::|          |.|..   .|..||..|.:.|:|...
Human   115 MRVFLQLRPEYRVHSYNASETSQLLSVSEGELILHKVRVNQNNL---QAQVIVDYLCKLSSLPAE 176

  Fly   132 KISEFENDTRFLRICRMLGRTVPKNNNANNKDLGDNGTAKRISGFRTDDLNTV------LGVAGD 190
            :.......|.|..:|::                    :.|:|..|.|.||..|      ||:...
Human   177 QHPVLLGSTSFALLCQL--------------------SVKKIQLFDTQDLINVLKAFVILGIPHS 221

  Fly   191 D-------------------EAAKLIA--------------------------SISLPQMVKVMS 210
            .                   :...|:|                          .:||.|:|.::.
Human   222 HSMLDVYETKCCHQVWEMNMDQLLLVADLWRYLGRKVPRFLNIFSSYLNLHWKDLSLSQLVHLIY 286

  Fly   211 TLAQRKRRSTPLLRSLAFNISSASESLDLKQAGDVL--FAMSTLNFQDSV---LGAKVCADVQSA 270
            .:.:.::.|..|::.|...|....:.::|::.|.:.  |..|:.|..:.|   :|...||::|..
Human   287 VIGENRQVSQDLMQKLESLILKYIDLINLEEVGTICLGFFKSSTNLSEFVMRKIGDLACANIQHL 351

  Fly   271 LPK---NVEK------------SAVVGSI----ITSLGI------------LRYRDLDILESLTQ 304
            ..:   |:.|            ...:|.|    |.|||:            ||:.:..::.::..
Human   352 SSRSLVNIVKMFRFTHVDHINFMKQIGEIAPQRIPSLGVQGVMHLTLYCSALRFLNEGVMNAVAA 416

  Fly   305 WLLKNSEICRPQDLSAYFLTSALLNFKSAQLEEVSKKLVKSIVRE--DFTKQSEWLSFVWSLTML 367
            .|......||.:|::....:...||:|....||....|:..|.|:  :|.:..|.|    ...:|
Human   417 SLPPRVAHCRSKDVAKILWSFGTLNYKPPNAEEFYSSLISEIHRKMPEFNQYPEHL----PTCLL 477

  Fly   368 GL--VEHGHLASV---LSADFLETLKKDKAGVTATSKMRLL----NLNSYAQLIATDYKGPLLPT 423
            ||  :|:..:..:   ||..|:...::       .:|..||    .|:....:...||:|..|.|
Human   478 GLAFLEYFPVELIDFALSPGFVRLAQE-------RTKFDLLKELYTLDGTVGIECPDYRGNRLST 535

  Fly   424 -----------------------------------DSPVY---QVPMAHPKAKQVLVNGMLDA-L 449
                                               ..|.|   .:.:.|.::..:.|  .||. |
Human   536 HLQQEGSELLWYLAEKDMNSKPEFLETVFLLETMLGGPQYVKHHMILPHTRSSDLEV--QLDVNL 598

  Fly   450 KSL------LPASN-------HLQTAV-DTKMGFLI--DALCHF----DANKNPLPLDKENPNAI 494
            |.|      .||.|       |:..:: |..|..|:  .|..||    ::.....|::.||..|:
Human   599 KPLPFNREATPAENVAKLRLEHVGVSLTDDLMNKLLKGKARGHFQGKTESEPGQQPMELENKAAV 663

  Fly   495 --------------------------------RVALMVIDFHDICHGTHRSGSGVTNLTFDLLEK 527
                                            ::|:...:.:..|:|: |...|:.|:....|.:
Human   664 PLGGFLCNVADKSGAMEMAGLCPAACMQTPRMKLAVQFTNRNQYCYGS-RDLLGLHNMKRRQLAR 727

  Fly   528 SGYHVIPVPYNEFSTSDKLLKRVQ 551
            .||.|:.:.|.|:.   .||||.:
Human   728 LGYRVVELSYWEWL---PLLKRTR 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13850	NP_001262834.1	FAST_1	319..385	CDD:284217	18/72 (25%)
		FAST_2	402..484	CDD:285557	27/144 (19%)
		RAP	498..556	CDD:214932	15/54 (28%)
FASTKD5	NP_068598.1	FAST_1	431..499	CDD:310980	17/71 (24%)
		FAST_2	514..601	CDD:312018	14/88 (16%)
		RAP	699..758	CDD:214932	15/54 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21228
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010