DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13850 and fastk

DIOPT Version :9

Sequence 1:	NP_001262834.1	Gene:	CG13850 / 42630	FlyBaseID:	FBgn0038961	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001164290.1	Gene:	fastk / 564534	ZFINID:	ZDB-GENE-070912-680	Length:	914	Species:	Danio rerio

Alignment Length:	721	Identity:	133/721 - (18%)
Similarity:	228/721 - (31%)	Gaps:	289/721 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 FSSSVRAAGIPVAPTGAQSDAVEPEARAPAVE----------EAAKKPRGHMVAAAF-----ESL 70
            ||||::               :.|.::.|.:|          |..:.|:...:..::     .:|
Zfish   292 FSSSMK---------------LHPSSQHPLIESCLAGLEKNIERERHPQTLFLLLSYYRTKWRAL 341

  Fly    71 RNDDPKDESKSQASSKIDERIINAKTVNGLLTITENNNGFSRKHALRIVSILAEWSTLNRVKISE 135
            |..|         ::..::.::|.|    :|.:.        ||.|..||         .|:..|
Zfish   342 RAAD---------TASPEQLVVNRK----ILRLV--------KHTLASVS---------SVRDHE 376

  Fly   136 FENDTRFLRICRMLGRTVPKNNNANNKDLG---------DNGTAKRISGFRTDDLNTVLGVAGDD 191
            .......|..|.         ..|:||.|.         .|...|.:|...             :
Zfish   377 MALLDEMLSACA---------REASNKSLELIFSSHLFYQNRQEKFVSSLA-------------E 419

  Fly   192 EAAKLIASISLPQMVKVMSTLAQRKRRSTPLLRSLAFNISSASESLDLKQAGDVLFAMSTLNFQ- 255
            |..|.:.||:...|..:...:|:.:.|.|.||.::|..:....|.||.|....::|..|.::::
Zfish   420 ELPKKVDSITPYTMALIAKYIARHRLRETRLLDTIADFLVKKGEYLDSKVIQKLVFPFSRMSYRP 484

  Fly   256 ----------DSVLGAKVCADVQSALPKNVEKS------------------AVVGSIITS---LG 289
                      :.||..|..:...:.:  |:..|                  :.:.::|.|   |.
Zfish   485 ANEAQFFSKLEMVLELKALSSPLATV--NILMSLFQLGHFPGLVLHRVFSPSFISNVINSPYALI 547

  Fly   290 ILRYRDLDILESLTQWLLKNSEICRPQDLSAYFLTSALLNFKSA-QLEEVSKKL-VKSIVREDFT 352
            :.||  |.:|::..:...::....|.||      |..:|.|..| ..:||::|. .|.:|.|...
Zfish   548 VRRY--LSLLDAAVELEYRDYTGPRLQD------THKVLMFDHALTADEVNRKYSYKGLVAEALR 604

  Fly   353 KQSEWLSFVWSLTMLGLVEHGH-----LASVLSADFLETLKKDKAG--------------VTATS 398
            :            ::|  |||:     ||.....|||  |..|..|              ..:::
Zfish   605 Q------------LVG--EHGYKQDEVLAPGYYTDFL--LWVDSTGRVLPIRTGTPAASLAASST 653

  Fly   399 KMRLLNLNS-----YAQLIATDYK--GPLL--------------PTDSPVYQVPMAHPKAKQVLV 442
            ...:|||.|     ....:.||::  .|..              .|..|.:..|.|...:::|..
Zfish   654 PCVVLNLKSPDGSGSVSTLTTDFQKFSPFATSLEEEADKRAGEESTFLPAHMRPAAASGSQRVGP 718

  Fly   443 NGML-----------DALKSLLPASNHLQTAVD-----------TKMGFLI-------DALCHFD 478
            ||.:           |...:|  |..|...:.|           |:.|..:       |:|..|.
Zfish   719 NGTVPLEYNPYYSTSDYYSNL--AKEHSLESQDSSTLSSPSDCLTQTGPSVPGTVAPQDSLFQFS 781

  Fly   479 ANK------------NP--------------------------LPLDKENPN---------AIRV 496
            ..|            ||                          .||...||:         ..:|
Zfish   782 IGKILEDEGGAATGANPGPDCEIATFYEGVSYPEGGESDGVTASPLQLHNPDNPEADHRTTGEQV 846

  Fly   497 ALMVIDFHDICHGTHRSGSGVTNLTFDLLEKS-----------GYHVIPVPYNEFSTSDKLLKRV 550
            ..:::..:|..|..|.|         |:|..|           ||:::.:||.|....:.:.:..
Zfish   847 KRVIMSVNDKWHYCHNS---------DVLVGSRAMRDRHLRLMGYNILQLPYLELEKLNGIEEVK 902

  Fly   551 QYLESK 556
            |||..|
Zfish   903 QYLHKK 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13850	NP_001262834.1	FAST_1	319..385	CDD:284217	18/72 (25%)
		FAST_2	402..484	CDD:285557	27/169 (16%)
		RAP	498..556	CDD:214932	15/68 (22%)
fastk	NP_001164290.1	FAST_1	471..538	CDD:284217	7/68 (10%)
		FAST_2	552..637	CDD:285557	27/106 (25%)
		RAP	853..908	CDD:214932	15/63 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28M88
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21228
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910