DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13850 and Tbrg4

DIOPT Version :9

Sequence 1:	NP_001262834.1	Gene:	CG13850 / 42630	FlyBaseID:	FBgn0038961	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001012154.1	Gene:	Tbrg4 / 360977	RGDID:	1309737	Length:	629	Species:	Rattus norvegicus

Alignment Length:	434	Identity:	110/434 - (25%)
Similarity:	189/434 - (43%)	Gaps:	70/434 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 ISGFRTDDLNTVLGVAG----------DDEAAKLIASISLPQMVKVMSTLAQRKRRSTPLLRSLA 227
            ||..||  |.:::.:||          :|:..:|:......::.||:.|||.:.|||.||||:::
  Rat   216 ISDSRT--LVSMMTMAGHLSESLMNRLEDKCLELVEQFGPDELRKVLMTLAAQSRRSVPLLRAIS 278

  Fly   228 FNISSASESLDLKQAGDVLFAMSTLNFQDSVLGAKVCAD----VQSALPKNVEKSAVVGSIITSL 288
            :::......:......|:.:|...|:|..:.:..::.||    :.|..|..|.:.|      .|.
  Rat   279 YHLVQKPFPMTKGMLLDLAYAYGKLSFHQTQVAQRLAADLLPFIPSMTPGEVARCA------KSF 337

  Fly   289 GILRYRDLDILESLTQWLLKNSEICRPQDLSAYFLTSALLNFKSAQLEEVSKKLVKSIVREDF-- 351
            ..|::.:|.:.|:.||.||.::     ||:|...|.|.||.|.........:....::|.|..
  Rat   338 AFLKWLNLPLFEAFTQHLLNSA-----QDVSLSHLCSVLLAFARLNFHPEQEDQFFNLVHEKLDS 397

  Fly   352 ----TKQSEWLSFVWSLTMLGLVEHGHLASVLSADFLETLKKDKAGVTATSKMRLLNLNSYAQLI 412
                .:.:..:..||:|.:|..|:...|.:||.........:.|:....::..:|:::||.|.|.
  Rat   398 VLGSLEPALQVDLVWALCVLQQVQVAELQTVLHPGLHTRFLESKSPKDQSTFQKLVHINSTALLE 462

  Fly   413 ATDYKGPLLPTDSPVYQVPMAHPKAKQVLVNGMLDALKSLLPASNHLQTAVDTKMGFLIDALCHF 477
            ..:||||.||. |.|...|....|....|...:.||||:||..::.....|.|:.|:::||....
  Rat   463 YPEYKGPFLPA-SAVAPSPSPSNKKMTPLQKELQDALKALLGNNDTGSLEVATQYGWVLDAEVLL 526

  Fly   478 DANKNPLPL--------------DKENPNAIRVALMVIDFHDICHGTHRSGSGVTNLTFDLLEK- 527
            ||..:.|||              ....|.|.|:|.:..:|.:.           .:.:.|||.:
  Rat   527 DAEGHFLPLRDFVAPHLAQPVGNQPLPPGAKRIAFLRWEFPNF-----------NSRSKDLLGRF 580

  Fly   528 ---------SGYHVIPVPYNEFSTSDKLLKRVQYLESKF-KAIA 561
                     :|:.|:.|||.|:.......::..||:.|. ||:|
  Rat   581 VLARRHVLAAGFLVVDVPYYEWLDLKSEWQKTAYLKDKMRKAVA 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13850	NP_001262834.1	FAST_1	319..385	CDD:284217	16/71 (23%)
		FAST_2	402..484	CDD:285557	29/81 (36%)
		RAP	498..556	CDD:214932	12/67 (18%)
Tbrg4	NP_001012154.1	FAST_1	368..436	CDD:399608	14/67 (21%)
		FAST_2	450..533	CDD:400599	29/83 (35%)
		RAP	561..618	CDD:214932	12/67 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	44	1.000	Domainoid score	I12015
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	106	1.000	Inparanoid score	I4842
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1209476at2759
OrthoFinder	1	1.000	-	-		FOG0008087
OrthoInspector	1	1.000	-	-		otm46080
orthoMCL	1	0.900	-	-		OOG6_110156
Panther	1	1.100	-	-	LDO	PTHR21228
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.970