DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13850 and FASTK

DIOPT Version :9

Sequence 1:	NP_001262834.1	Gene:	CG13850 / 42630	FlyBaseID:	FBgn0038961	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_006703.1	Gene:	FASTK / 10922	HGNCID:	24676	Length:	549	Species:	Homo sapiens

Alignment Length:	344	Identity:	68/344 - (19%)
Similarity:	120/344 - (34%)	Gaps:	93/344 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   291 LRYRDLDILESLTQWLLKNSEICRPQDLSAYF-----------------LTSALLNFKSAQLEEV 338
            |||....::.||.:        .||::|:.:.                 |..|:.:|...|..::
Human   216 LRYPRQHLISSLAE--------ARPEELTPHVMVLLAQHLARHRLREPQLLEAIAHFLVVQETQL 272

  Fly   339 SKKLVKSIV------------------------REDFTKQSEWLSFVWSLTMLGLVEHGHLASVL 379
            |.|:|:.:|                        ||........::.:.||..|..:....|..|.
Human   273 SSKVVQKLVLPFGRLNYLPLEQQFMPCLERILAREAGVAPLATVNILMSLCQLRCLPFRALHFVF 337

  Fly   380 SADFLETLKKDKAGVTATSKMRLLNLNSYAQLIATDYKGPLLP--TDSPVYQVPMAHPKA----- 437
            |..|:..:......:.....:.|  |::..:|....|:||.||  ...|::..|:...:|
Human   338 SPGFINYISGTPHALIVRRYLSL--LDTAVELELPGYRGPRLPRRQQVPIFPQPLITDRARCKYS 400

  Fly   438 -KQVLVNGMLDALKSLLPASNHLQTAVDTKMGFLIDALCHFDANKNPLPLDKENP---------- 491
             |.::..|    |:.||....:.|. :....|:..|.|....::...||:..::|
Human   401 HKDIVAEG----LRQLLGEEKYRQD-LTVPPGYCTDFLLCASSSGAVLPVRTQDPFLPYPPRSCP 460

  Fly   492 ------------NAIRVALMVIDFHDICHGTHRSGS---GVTNLTFDLLEKSGYHVIPVPYNEFS 541
                        .|.||.|::.:....|    |.|.   |...|....|...||.::|:|:.|..
Human   461 QGQAASSATTRDPAQRVVLVLRERWHFC----RDGRVLLGSRALRERHLGLMGYQLLPLPFEELE 521

  Fly   542 TSDKLLKRVQYLESKFKAI 560
            :...|.:...||..|.:|:
Human   522 SQRGLPQLKSYLRQKLQAL 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13850	NP_001262834.1	FAST_1	319..385	CDD:284217	17/106 (16%)
		FAST_2	402..484	CDD:285557	20/89 (22%)
		RAP	498..556	CDD:214932	15/60 (25%)
FASTK	NP_006703.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		FAST_1	278..343	CDD:310980	10/64 (16%)
		FAST_2	358..443	CDD:312018	20/91 (22%)
		RAP	484..536	CDD:214932	14/55 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28M88
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21228
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910