Protein Alignment CG18596 and AgaP_AGAP005864

DIOPT Version :9

• Sequence 1: NP_651031.1
• Gene: CG18596 / 42622
• FlyBaseID: FBgn0038953
• Length: 1136
• Species: Drosophila melanogaster
• Sequence 2: XP_315892.4
• Gene: AgaP_AGAP005864 / 1276532
• VectorBaseID: AGAP005864
• Length: 1386
• Species: Anopheles gambiae
• Alignment Length: 1509
• Identity: 285/1509 - (18%)
• Similarity: 512/1509 - (33%)
• Gaps: 523/1509 - (34%)

  Fly     9 TTATTTH----AVVQAVETYIQNQNLLGEIAELDDMLYDLVS----------MHKDNELALKRVL 59
            ||.|..|    .:.|:.:.::||.:.|.: ..|:.::|.|:.          :|..|   |:.:|
Mosquito    13 TTDTEAHEQLIQLAQSEQIFLQNVHNLHK-PSLEALVYALLMKQRGKLPASLLHGVN---LQTIL 73

  Fly    60 QCI---HNLLQTNSKYNVRFGPKVFHKLVSVVIADSREDSASRRQLVANLLVCVQLHIRKFPRIE 121
            ..:   |:.||.:|                    ||...:.|...|.|.|...:|:.||:.....
Mosquito    74 SLVDGNHDRLQGDS--------------------DSLRWTLSALALTALLESDLQIVIRELTTFV 118

  Fly   122 AKFVLQQLWSLSQSNERQPHAAQILVHLFD----------------------DFVNNLGTE---- 160
            .:|            ||:.||..:...:..                      |.|..|.::
Mosquito   119 DRF------------ERELHATPVYYDVLQTFLILAQELPELVAICNRANGADMVRRLQSDSRVM 171

  Fly   161 ------CAQELLVLTRNLLQSDVRDDRRSAY------FLMHKLQEI---------DEVLAALQ-- 202
                  |.|.::.|..:|::..:.:.|..|:      ||:.:|.|.         .::|:|||
Mosquito   172 RTKALACLQTMMELNPDLVEQWLSETRSPAHPIERKVFLLRELLEALLRCTGDRKADILSALQLD 236

  Fly   203 ----------------------------------------------------CSEVQWSAYVGIM 215
                                                                |.:. |.:.|.::
Mosquito   237 HLWLVVFEALVSRDAVCRMEAVAILRHAIGYAMHCEMSFTGQYFAWWPEWEKCCDA-WQSIVAVL 300

  Fly   216 ENLEEQQSHLVLPTLSTLLPRMGLMSNNLSEDWLDWLRILCIRLLGDNNILVLRWTLKYFLSHFS 280
            |.|:|.:..:.:..:..||..:         .| :|..:|...||...|..|:.....|||.:
Mosquito   301 ERLDEFKLAVPMEQIEKLLVLL---------HW-EWKTVLFRLLLDHTNGQVVMHVHDYFLKY-- 353

  Fly   281 LEQISRFN-----LLTQFLAATNRTQL-YNPEVP----DCLTKQQITDFSAQFPAEILLEALVCV 335
                .:||     :..:.|...||..| ....||    |.|:|.    :..|...:.||:.:..:
Mosquito   354 ----RKFNATEAEMEKRLLDGLNRAPLAAGGSVPKGVIDKLSKY----YDTQKAYDYLLQTIPEL 410

  Fly   336 PWHAVPLIHWLQAWELKQLPVVSKELLFKLGAR----------VRSL----------QNPVLRGE 380
            .|:.| ..|.:.:        |..:..|||.|:          :|||          :|..||..
Mosquito   411 SWNPV-AFHCIVS--------VVHQRTFKLAAQCKRRQETAATIRSLTSCAKVCHDIKNLPLRFA 466

  Fly   381 A-------INY---------VIFSLSATIDSLS-----------LGDYLLFMESLYN-------- 410
            |       :|.         |:.::.|.:..|:           ..|..||::.|.|
Mosquito   467 AFVLLVHCVNQLAEPTTDAAVLLAVVAEMQKLTPMFAITQEHFRSPDGSLFLDRLTNDALEPHWG 531

  Fly   411 ---TIDRYQSHSQLAQKIRN----CSNLEKHIASFNIR-CCELVSQM-DYKHDVFVA----FLEK 462
               ..|.:.....|.|:.:|    |..|..|:...||. ||:|:..| :..:.||.:    |...
Mosquito   532 RVSPADTFLIEQVLVQRAKNSLYACLELSSHMLESNISVCCKLLGHMPESVNSVFNSICNNFQSA 596

  Fly   463 LRTVPKSKHGWWRLLP----------IFLH-----RELDHPE----------------------- 489
            :.::.:::....| :|          |.|.     |:.|:|.
Mosquito   597 VDSIRQAQEAGER-IPQQAFAVREQLIALQEAVDKRKFDYPPNLSGMMSLMKELQAFVDERLQSF 660

  Fly   490 QYLDFYRSVYDLDTS---------------FLESGVSLEQMQQHLLNRLDCQ-------TREEKS 532
            .|.|..|::..:..:               |.:| ||:    |.|.|.||.:       |.:..:
Mosquito   661 DYADHARAIETIQLTHLIAWHEDCCKVASLFFQS-VSV----QELKNSLDRRGVGEAPTTDQVYA 720

  Fly   533 FVLE------HSVDLFVQI--NLPTWSKLEVL-----------------------------NLNP 560
            .|:|      ..|..|::|  ....||.|.:|                             |.|.
Mosquito   721 MVVEIHLNYRQHVQNFIEIYKTEEHWSGLHILFDIDNVDVLTLAVELLYADCKKMEDVRYRNSNR 785

  Fly   561 LELLDRGTEETFATLSNILSTHDEQLADQNVLPAFISRLGKLKVRETQAILKYAVQNLSSE--EY 623
            :.::||..|:       ||:.|..:       ..|::.:.|        .:|..:..|.:|  ||
Mosquito   786 VNMIDRCYEK-------ILTHHQSE-------DHFLTLMSK--------FVKMLLDPLCAENMEY 828

  Fly   624 EKCVVDVLEKNTFL---------------LGTMDC-----EEYIKAPTSFVIKRMLQ----GETT 664
            :...:.....| :|               |..::|     ||:.:.....::|.:.|    |:..
Mosquito   829 DDVYIPDFVLN-YLSMFFEQGSSTTQELPLVVLECLVRFPEEFFRYFHWLIVKILAQGMIFGKGP 892

  Fly   665 TGDARIERAFEQISDTGAMDRVQFIQYAKNSTGLDISFICDDLLRMNNELSRKKPRYFANCK--- 726
            ..|||:::.::.   .|.|.||....:........:....:.:.::...|.    :||...|
Mosquito   893 MRDARLKKRYQA---DGRMVRVMCSLFLHRFNHFKVGAFNNLVTKVEENLM----QYFTESKLVM 950

  Fly   727 --EHRMKMRIGKALLDLSDRW--------------KWSDNLWEAVLCPSDQPNISFMYEYLVSKM 775
              .||.:      :..|...|              ...|.|.:|:|..::...|..:.|.:|
Mosquito   951 HHVHRFE------IYPLQKLWAAQALCIAVSIAGCSKPDVLLKALLYEANPTCIQRLLELIV--- 1006

  Fly   776 LPSIDLLLEQLKLLATLK-----PSQQISLVSVVHIYCLTRWESIQHEQLVEVFAVLLPLTMGAN 835
               :|..:..|.:..:||     |:...|:..::.:.| .|.:::.::.:.    :|:|.||..:
Mosquito  1007 ---VDSEISTLAIANSLKDGKVTPAGIESICGILWLRC-CRDKTLNNQSIY----LLMPWTMAES 1063

  Fly   836 FQTRLLAQLVLHRICSECEDRSIQMPIADALKKSIK--VTL---SEKLTEFQCEARLLLPELGKQ 895
            |...|.||:.:.::.:.         .|.|.|...|  .|:   |.:.|..:.....:|.::..|
Mosquito  1064 FTIGLWAQITISKLLAR---------FARADKPQFKQMYTMFKQSHQQTNIKPHVTRILRDVRFQ 1119

  Fly   896 CPTSVSDCIL----MMTNAPFDENISFISCSYDFRMK-------------LKRALETFKRKQSVL 943
            ..   |:|:|    :..|.|....:.....:....:|             |.:|:...|..:.|:
Mosquito  1120 LD---SNCLLTFENVFHNIPKAAGVPAEDVAGTALLKACVQLLDGLGEKFLGKAMRVQKLPREVV 1181

  Fly   944 ----IPELATSLAALNGNVQRKMNPVGDIYPESDFVV--------SNKARDDHE-LIVVASLIDK 995
                :|...|.........:..:.|:..:.|..|.::        |.:.|:..: |.||||.:..
Mosquito  1182 ETNRVPYQPTDWTGYFVPPEHAIVPLKRLDPRQDLMLELPYRLYNSQQKREASKGLYVVASNVTN 1246

  Fly   996 LPNLGGLARTCEVLGVNTLILGLKSQAEKSDFTNLSMTAEKTLNILEVNPESLAGFLLEKQMEGY 1060
            :|:|..|||..:..|:..|.:......:...|...|.:.|:...:.|:...::..:|.:.|.:||
Mosquito  1247 VPDLADLARMGKRFGIKQLFINSLQDLDSKQFKMRSASVEQWQTVRELKAHNVYSYLWDLQDKGY 1311

  Fly  1061 KIVGAE--QTAHSTNFVDFKFPKKSILLLGHEKHGIPANLIGFLDYA---VEIPQYGLVRSLNVH 1120
            .:|..:  :|..||.....:.|||.:|:|         ||:....:|   |.||..|..|.|.|.
Mosquito  1312 TLVNVKHTETPQSTPLHQLQLPKKCVLVL---------NLLERFPHAVLNVYIPPIGAKRLLTVP 1367

  Fly  1121 VAGSLFIWEYCKQH 1134
            ...:|.:|||.|||
Mosquito  1368 ETAALLMWEYAKQH 1381

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18596	NP_651031.1	SpoU_methylase	986..1128	CDD:278985	40/146 (27%)
AgaP_AGAP005864	XP_315892.4	SpoU_methylase	1236..1375	CDD:304396	40/147 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0566
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	247	1.000	Inparanoid score	I5621
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002756
OrthoInspector	1	1.000	-	-		otm50907
Panther	1	1.100	-	-	O	PTHR12029
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4127
TreeFam	1	0.960	-	-
	8	8.010