DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7069 and PYK2

DIOPT Version :9

Sequence 1:	NP_651030.1	Gene:	CG7069 / 42621	FlyBaseID:	FBgn0038952	Length:	744	Species:	Drosophila melanogaster
Sequence 2:	NP_014992.3	Gene:	PYK2 / 854529	SGDID:	S000005874	Length:	506	Species:	Saccharomyces cerevisiae

Alignment Length:	482	Identity:	197/482 - (40%)
Similarity:	286/482 - (59%)	Gaps:	41/482 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRVVRMNFSHGSHEYHCQTIQAARKAIAMYVEQTGLPRTLAIALDTKGPEIRTGKLAGGNDRAEI 65
            :.::|:||||||:|:|...|:.|.|:     ||....|.|||||||||||||||:..  ||: ::
Yeast    47 LNIIRLNFSHGSYEFHQSVIENAVKS-----EQQFPGRPLAIALDTKGPEIRTGRTL--NDQ-DL 103

  Fly    66 ELKTGDKVTLSTKKEMADKSNKDNIYVDYQRLPQLVKPGNRVFVDDGLIAL----IVKESKGDEV 126
            .:....::..:|....|:.||...:|:||..|.:::.||..::||||:::.    |:.||   .:
Yeast   104 YIPVDHQMIFTTDASFANTSNDKIMYIDYANLTKVIVPGRFIYVDDGILSFKVLQIIDES---NL 165

  Fly   127 ICQVENGGKLGSHKGINLPGVPVDLPSVTEKDKQDLKFGAEQKVDMIFASFIRDANALKEIRQVL 191
            ..|..|.|.:.||||:|||...||||.::.||.:||:||....:.::||||||.:..:..||:.|
Yeast   166 RVQAVNSGYIASHKGVNLPNTDVDLPPLSAKDMKDLQFGVRNGIHIVFASFIRTSEDVLSIRKAL 230

  Fly   192 GPAGACIKIISKIENHQGLVNIDDIIRESDGIMVARGDMGIEIPTEDVPLAQKSIVAKCNKVGKP 256
            |..|..|||||||||.|||.|.|:|:..:||:|:||||:||||...:|...||.::||||..|||
Yeast   231 GSEGQDIKIISKIENQQGLDNFDEILEVTDGVMIARGDLGIEILAPEVLAIQKKLIAKCNLAGKP 295

  Fly   257 VICATQMMESMTNKPRPTRAEASDVANAIFDGCDAVMLSGETAKGKYPVECVQCMARICAKVEAV 321
            |||||||::|||:.|||||||.|||.||:.||.|.||||||||||.|||..|..||......|:.
Yeast   296 VICATQMLDSMTHNPRPTRAEVSDVGNAVLDGADCVMLSGETAKGDYPVNAVNIMAATALIAEST 360

  Fly   322 LWYESLQNSLKREIRTSAADHISAVTTAIAEAATVG----QARAIVVASPCSMVAQMVSHMRPPC 382
            :.:.:|.:.|:     .|....::.|..:|.|||..    ..:||||.|.....|:::|..||.|
Yeast   361 IAHLALYDDLR-----DATPKPTSTTETVAAAATAAILEQDGKAIVVLSTTGNTARLLSKYRPSC 420

  Fly   383 PIVMLTGNESEAAQSLLFRGIYPLLVEEMVIGSF--NFRRIMQSGLKLMGKMDILEPGQ------ 439
            ||:::|.:...|..:.|:||::|.|.|...:..:  :..|.::.|:::.....:::.|.
Yeast   421 PIILVTRHARTARIAHLYRGVFPFLYEPKRLDDWGEDVHRRLKFGVEMARSFGMVDNGDTVVSIQ 485

  Fly   440 --KGSVVLVNAMSAEKITFRLFTIRQQ 464
              ||.|...|       |.|:.|:.|:
Yeast   486 GFKGGVGHSN-------TLRISTVGQE 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7069	NP_651030.1	PRK05826	1..446	CDD:235619	192/462 (42%)
CG7069	NP_651030.1	Pyruvate_Kinase	1..410	CDD:304951	185/416 (44%)
PYK2	NP_014992.3	Pyruvate_Kinase	20..502	CDD:238178	195/477 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343744
Domainoid	1	1.000	363	1.000	Domainoid score	I126
eggNOG	1	0.900	-	-		E1_COG0469
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9216
orthoMCL	1	0.900	-	-		OOG6_100258
Panther	1	1.100	-	-	O	PTHR11817
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X374
TreeFam	1	0.960	-	-
	9	8.700