DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7069 and pyk1

DIOPT Version :9

Sequence 1:	NP_651030.1	Gene:	CG7069 / 42621	FlyBaseID:	FBgn0038952	Length:	744	Species:	Drosophila melanogaster
Sequence 2:	NP_594346.1	Gene:	pyk1 / 2543557	PomBaseID:	SPAC4H3.10c	Length:	509	Species:	Schizosaccharomyces pombe

Alignment Length:	465	Identity:	222/465 - (47%)
Similarity:	288/465 - (61%)	Gaps:	18/465 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRVVRMNFSHGSHEYHCQTIQAARKAIAMYVEQTGLPRTLAIALDTKGPEIRTGKLAGGNDRAEI 65
            |.:|||||||||:|||...|..||||.|     |.....|||||||||||||||...||.|   .
pombe    52 MNIVRMNFSHGSYEYHQSVIDNARKASA-----TNPLFPLAIALDTKGPEIRTGLTVGGTD---Y 108

  Fly    66 ELKTGDKVTLSTKKEMADKSNKDNIYVDYQRLPQLVKPGNRVFVDDGLIALIVKESKGDEVI-CQ 129
            .:.:|.::..:|....|:|.|...:|:||:.:.::::||..::||||:::..|.|...|:.: .:
pombe   109 PISSGHEMIFTTDDAYAEKCNDKVMYIDYKNITKVIQPGRIIYVDDGILSFTVIEKVDDKNLKVR 173

  Fly   130 VENGGKLGSHKGINLPGVPVDLPSVTEKDKQDLKFGAEQKVDMIFASFIRDANALKEIRQVLGPA 194
            |.|.||:.|.||:|||...||||:::||||.||:||.:..||||||||||.|..:..||:|||..
pombe   174 VNNNGKISSKKGVNLPKTDVDLPALSEKDKADLRFGVKNGVDMIFASFIRRAEDVIHIREVLGEE 238

  Fly   195 GACIKIISKIENHQGLVNIDDIIRESDGIMVARGDMGIEIPTEDVPLAQKSIVAKCNKVGKPVIC 259
            |..||||.||||.||:.|.|.|:..:|||||||||:|||||...|.:|||.::||||..||||.|
pombe   239 GKNIKIICKIENQQGVNNFDSILDVTDGIMVARGDLGIEIPASQVFVAQKMMIAKCNIAGKPVAC 303

  Fly   260 ATQMMESMTNKPRPTRAEASDVANAIFDGCDAVMLSGETAKGKYPVECVQCMARICAKVEAVLWY 324
            ||||:||||..|||||||.|||.||:.||.|.|||||||.||.||||.|..||......||.:.|
pombe   304 ATQMLESMTYNPRPTRAEVSDVGNAVLDGADLVMLSGETTKGSYPVEAVTYMAETARVAEASIPY 368

  Fly   325 ESLQNSLKREIRTSAADHISAVTTAIAE--AATVGQARAIVVASPCSMVAQMVSHMRPPCPIVML 387
            .||...:...:|...  ..:..|||:|.  |:....|:||||.|.....|::.|..||..||||:
pombe   369 GSLYQEMFGLVRRPL--ECATETTAVAAIGASIESDAKAIVVLSTSGNTARLCSKYRPSIPIVMV 431

  Fly   388 TGNESEAAQSLLFRGIYPLLVEEMVIGSF--NFRRIMQSGLKLMGKMDILEPGQKGSVVLVNAMS 450
            |.....|.||.|.||:||::.|:..:..:  :....:..|.:...||:||:.|.| .:||..|:.
pombe   432 TRCPQRARQSHLNRGVYPVIYEKEPLSDWQKDVDARVAYGCQQAYKMNILKKGDK-IIVLQGAVG 495

  Fly   451 AEKIT--FRL 458
            .:..|  |||
pombe   496 GKGHTSIFRL 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7069	NP_651030.1	PRK05826	1..446	CDD:235619	216/449 (48%)
CG7069	NP_651030.1	Pyruvate_Kinase	1..410	CDD:304951	207/411 (50%)
pyk1	NP_594346.1	Pyruvate_Kinase	25..508	CDD:238178	222/465 (48%)
pyk1	NP_594346.1	pyruv_kin	26..505	CDD:273424	220/463 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	393	1.000	Domainoid score	I117
eggNOG	1	0.900	-	-		E1_COG0469
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100258
Panther	1	1.100	-	-	O	PTHR11817
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X374
TreeFam	1	0.960	-	-
	7	6.770