DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7069 and Pkm

DIOPT Version :9

Sequence 1:	NP_651030.1	Gene:	CG7069 / 42621	FlyBaseID:	FBgn0038952	Length:	744	Species:	Drosophila melanogaster
Sequence 2:	XP_011240976.2	Gene:	Pkm / 18746	MGIID:	97591	Length:	604	Species:	Mus musculus

Alignment Length:	457	Identity:	220/457 - (48%)
Similarity:	303/457 - (66%)	Gaps:	25/457 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRVVRMNFSHGSHEYHCQTIQAARKAIAMYVEQTGLPRTLAIALDTKGPEIRTGKLAGGNDRAEI 65
            |.|.|:|||||:||||.:||:..|:|...:.....|.|.:|:|||||||||||| |..|:..||:
Mouse   142 MNVARLNFSHGTHEYHAETIKNVREATESFASDPILYRPVAVALDTKGPEIRTG-LIKGSGTAEV 205

  Fly    66 ELKTGDKVTLSTKKEMADKSNKDNIYVDYQRLPQLVKPGNRVFVDDGLIALIVKESKGDEVICQV 130
            |||.|..:.::......:|.:::.:::||:.:.::|:.|::::||||||:|.|||...|.::.:|
Mouse   206 ELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADFLVTEV 270

  Fly   131 ENGGKLGSHKGINLPGVPVDLPSVTEKDKQDLKFGAEQKVDMIFASFIRDANALKEIRQVLGPAG 195
            ||||.|||.||:||||..||||:|:|||.||||||.||.|||:||||||.|..:.|:|:|||..|
Mouse   271 ENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKG 335

  Fly   196 ACIKIISKIENHQGLVNIDDIIRESDGIMVARGDMGIEIPTEDVPLAQKSIVAKCNKVGKPVICA 260
            ..||||||||||:|:...|:|:..||||||||||:|||||.|.|.||||.::.:||:.|||||||
Mouse   336 KNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICA 400

  Fly   261 TQMMESMTNKPRPTRAEASDVANAIFDGCDAVMLSGETAKGKYPVECVQCMARICAKVEAVLWYE 325
            |||:|||..||||||||.||||||:.||.|.:|||||||||.||:|.|:....|..:.||.:::.
Mouse   401 TQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHL 465

  Fly   326 SLQNSLKREIRTSAADHISAVTTAIAEAATVGQAR--------AIVVASPCSMVAQMVSHMRPPC 382
            .|...|:|         ::.:|:...|||.||...        ||:|.:.....|..|:..||..
Mouse   466 QLFEELRR---------LAPITSDPTEAAAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRA 521

  Fly   383 PIVMLTGNESEAAQSLLFRGIYPLLVEEMVIGSFNFRRIMQSGLKLMGKMDILEPG---QKGSVV 444
            ||:.:|.|...|.|:.|:|||:|:|.::.|:.::    .....|::...||:.:..   :||.||
Mouse   522 PIIAVTRNPQTARQAHLYRGIFPVLCKDAVLNAW----AEDVDLRVNLAMDVGKARGFFKKGDVV 582

  Fly   445 LV 446
            :|
Mouse   583 IV 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7069	NP_651030.1	PRK05826	1..446	CDD:235619	219/455 (48%)
CG7069	NP_651030.1	Pyruvate_Kinase	1..410	CDD:304951	211/416 (51%)
Pkm	XP_011240976.2	Pyruvate_Kinase	115..603	CDD:238178	220/457 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0469
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D219692at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100258
Panther	1	1.100	-	-	O	PTHR11817
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X374
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.780