Protein Alignment PyK and pykA

DIOPT Version :10

• Sequence 1: NP_524448.3
• Gene: PyK / 42620
• FlyBaseID: FBgn0267385
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: NP_416368.1
• Gene: pykA / 946527
• ECOCYCID: EG10803
• Length: 480
• Species: Escherichia coli
• Alignment Length: 508
• Identity: 191/508 - (37%)
• Similarity: 272/508 - (53%)
• Gaps: 51/508 - (10%)

  Fly    45 VRLSGIVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAVKNYSAKLGYEH 109
            :|.:.||.|:|||:.....|||::|.|.|:.||||||||.|.|......||:    .:|||| .|
E. coli     5 LRRTKIVTTLGPATDRDNNLEKVIAAGANVVRMNFSHGSPEDHKMRADKVRE----IAAKLG-RH 64

  Fly   110 PVAIALDTKGPEIRTGLIGGSGTAEIELKKGEKIKLTTNKEFLEK--GSLEIVYVDYENIVNVVK 172
             |||..|.:||:||   :......::.|..|:|..|..|   |.|  |..|.|.:||:.:...|.
E. coli    65 -VAILGDLQGPKIR---VSTFKEGKVFLNIGDKFLLDAN---LGKGEGDKEKVGIDYKGLPADVV 122

  Fly   173 PGNRVFVDDGLISLIVREVGKDSLTCEVENGGSLGSRKGVNLPGVPVDLPAVSEKDKSDLLFGVE 237
            ||:.:.:|||.:.|.|.||....:..||..||.|.:.||:|..|..:...|::||||:|:.....
E. coli   123 PGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGINKLGGGLSAEALTEKDKADIKTAAL 187

  Fly   238 QEVDMIFASFIRNAAALTEIRKVLGEKGKNIKIISKIENQQGMHN---LDEIIEAGDGIMVARGD 299
            ..||.:..||.|....|...|::..:.|.:.||::|:|..:.:.:   :|:||.|.|.:||||||
E. coli   188 IGVDYLAVSFPRCGEDLNYARRLARDAGCDAKIVAKVERAEAVCSQDAMDDIILASDVVMVARGD 252

  Fly   300 LGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISDVANAVLDGADCVML 364
            ||:||...::...|||:|.|..:..:.||.||||:|||:..|.|||||:.|||||||||.|.|||
E. coli   253 LGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVML 317

  Fly   365 SGETAKGEYPLECVLTMAKTCKEAEAALWHQNLFNDLVRGAGTIDAS------------HAAAIA 417
            |.|||.|:||.|.|..||:.|..||.              ..:|:.|            .|.|::
E. coli   318 SAETAAGQYPSETVAAMARVCLGAEK--------------IPSINVSKHRLDVQFDNVEEAIAMS 368

  Fly   418 AVEAATKAK-ASAIVVITTSGKSAFQVSKYRPRCPIIAVTRFAQTARQAHLYRGLVPLIYKEPGL 481
            |:.||...| .:||:.:|.||::|...|:.....||.|::|..:|.....||||:.|:.:
E. coli   369 AMYAANHLKGVTAIITMTESGRTALMTSRISSGLPIFAMSRHERTLNLTALYRGVTPVHF----- 428

  Fly   482 GDWLKDVDVRVQFGLQVGKKNGFIKTGDSVVVVTGWKQGS-GFTNTIRIVTVE 533
             |...|........:.:.:..|::.:||.|:|..|....: |.|||.||:|||
E. coli   429 -DSANDGVAAASEAVNLLRDKGYLMSGDLVIVTQGDVMSTVGSTNTTRILTVE 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PyK	NP_524448.3	Pyruvate_Kinase	46..532	CDD:238178	188/504 (37%)
pykA	NP_416368.1	PRK05826	3..469	CDD:235619	182/495 (37%)