DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PyK and PYK2

DIOPT Version :9

Sequence 1:	NP_524448.3	Gene:	PyK / 42620	FlyBaseID:	FBgn0267385	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_014992.3	Gene:	PYK2 / 854529	SGDID:	S000005874	Length:	506	Species:	Saccharomyces cerevisiae

Alignment Length:	511	Identity:	241/511 - (47%)
Similarity:	341/511 - (66%)	Gaps:	16/511 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 DTQLEHMCRLQFDSPVPHVRLSGIVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATV 91
            :::|:.:..|:..:| ..:|.:.|:.||||.::|.|.:..:...|:||.|:||||||:|:|.:.:
Yeast     3 ESRLQRLANLKIGTP-QQLRRTSIIGTIGPKTNSCEAITALRKAGLNIIRLNFSHGSYEFHQSVI 66

  Fly    92 ANVRQAVKNYSAKLGYEHPVAIALDTKGPEIRTGLIGGSGTAEIELKKGEKIKLTTNKEFLEKGS 156
            .|..::.:.:..:     |:||||||||||||||..  ....::.:....::..||:..|....:
Yeast    67 ENAVKSEQQFPGR-----PLAIALDTKGPEIRTGRT--LNDQDLYIPVDHQMIFTTDASFANTSN 124

  Fly   157 LEIVYVDYENIVNVVKPGNRVFVDDGLISL-IVREVGKDSLTCEVENGGSLGSRKGVNLPGVPVD 220
            .:|:|:||.|:..|:.||..::||||::|. :::.:.:.:|..:..|.|.:.|.||||||...||
Yeast   125 DKIMYIDYANLTKVIVPGRFIYVDDGILSFKVLQIIDESNLRVQAVNSGYIASHKGVNLPNTDVD 189

  Fly   221 LPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEKGKNIKIISKIENQQGMHNLDE 285
            ||.:|.||..||.|||...:.::||||||.:..:..|||.||.:|::||||||||||||:.|.||
Yeast   190 LPPLSAKDMKDLQFGVRNGIHIVFASFIRTSEDVLSIRKALGSEGQDIKIISKIENQQGLDNFDE 254

  Fly   286 IIEAGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISD 350
            |:|..||:|:|||||||||.|.:|...||.:||:||.||||||||||||:||...|||||||:||
Yeast   255 ILEVTDGVMIARGDLGIEILAPEVLAIQKKLIAKCNLAGKPVICATQMLDSMTHNPRPTRAEVSD 319

  Fly   351 VANAVLDGADCVMLSGETAKGEYPLECVLTMAKTCKEAEAALWHQNLFNDL----VRGAGTIDAS 411
            |.|||||||||||||||||||:||:..|..||.|...||:.:.|..|::||    .:...|.:..
Yeast   320 VGNAVLDGADCVMLSGETAKGDYPVNAVNIMAATALIAESTIAHLALYDDLRDATPKPTSTTETV 384

  Fly   412 HAAAIAAVEAATKAKASAIVVITTSGKSAFQVSKYRPRCPIIAVTRFAQTARQAHLYRGLVPLIY 476
            .|||.||:   .:....||||::|:|.:|..:|||||.||||.|||.|:|||.||||||:.|.:|
Yeast   385 AAAATAAI---LEQDGKAIVVLSTTGNTARLLSKYRPSCPIILVTRHARTARIAHLYRGVFPFLY 446

  Fly   477 KEPGLGDWLKDVDVRVQFGLQVGKKNGFIKTGDSVVVVTGWKQGSGFTNTIRIVTV 532
            :...|.||.:||..|::||:::.:..|.:..||:||.:.|:|.|.|.:||:||.||
Yeast   447 EPKRLDDWGEDVHRRLKFGVEMARSFGMVDNGDTVVSIQGFKGGVGHSNTLRISTV 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PyK	NP_524448.3	Pyruvate_Kinase	46..532	CDD:238178	236/490 (48%)
PyK	NP_524448.3	pyruv_kin	46..529	CDD:273424	234/487 (48%)
PYK2	NP_014992.3	Pyruvate_Kinase	20..502	CDD:238178	236/491 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343740
Domainoid	1	1.000	363	1.000	Domainoid score	I126
eggNOG	1	0.900	-	-		E1_COG0469
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	471	1.000	Inparanoid score	I230
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53565
OrthoFinder	1	1.000	-	-		FOG0000841
OrthoInspector	1	1.000	-	-		mtm9214
orthoMCL	1	0.900	-	-		OOG6_100258
Panther	1	1.100	-	-	O	PTHR11817
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2173
SonicParanoid	1	1.000	-	-		X374
TreeFam	1	0.960	-	-
	14	13.790