DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PyK and CDC19

DIOPT Version :9

Sequence 1:	NP_524448.3	Gene:	PyK / 42620	FlyBaseID:	FBgn0267385	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_009362.1	Gene:	CDC19 / 851193	SGDID:	S000000036	Length:	500	Species:	Saccharomyces cerevisiae

Alignment Length:	517	Identity:	252/517 - (48%)
Similarity:	346/517 - (66%)	Gaps:	32/517 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NMAAGADTQLEHMCRLQFDSPVPHVRLSGIVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHE 85
            |:.||:|                 :|.:.|:.||||.:::.|.|..:...|:||.||||||||:|
Yeast    11 NVVAGSD-----------------LRRTSIIGTIGPKTNNPETLVALRKAGLNIVRMNFSHGSYE 58

  Fly    86 YHAATVANVRQAVKNYSAKLGYEHPVAIALDTKGPEIRTGLIGGSGTAEIELKKGEKIKLTTNKE 150
            ||.:.:.|.|::.:.|..:     |:||||||||||||||..  :...:..:....::..||:.:
Yeast    59 YHKSVIDNARKSEELYPGR-----PLAIALDTKGPEIRTGTT--TNDVDYPIPPNHEMIFTTDDK 116

  Fly   151 FLEKGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKD-SLTCEVENGGSLGSRKGVNL 214
            :.:....:|:||||:||..|:..|..::||||::|..|.||..| :|..:..|.|.:.|.|||||
Yeast   117 YAKACDDKIMYVDYKNITKVISAGRIIYVDDGVLSFQVLEVVDDKTLKVKALNAGKICSHKGVNL 181

  Fly   215 PGVPVDLPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEKGKNIKIISKIENQQG 279
            ||..|||||:|||||.||.|||:..|.|:||||||.|..:..||:||||:||::|||.|||||||
Yeast   182 PGTDVDLPALSEKDKEDLRFGVKNGVHMVFASFIRTANDVLTIREVLGEQGKDVKIIVKIENQQG 246

  Fly   280 MHNLDEIIEAGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPT 344
            ::|.|||::..||:|||||||||||||.:|...||.:||:.|.|||||||||||||||...||||
Yeast   247 VNNFDEILKVTDGVMVARGDLGIEIPAPEVLAVQKKLIAKSNLAGKPVICATQMLESMTYNPRPT 311

  Fly   345 RAEISDVANAVLDGADCVMLSGETAKGEYPLECVLTMAKTCKEAEAALWHQNLFNDL----VRGA 405
            |||:|||.||:||||||||||||||||.||:..|.|||:|...||.|:.:...::|:    .:..
Yeast   312 RAEVSDVGNAILDGADCVMLSGETAKGNYPINAVTTMAETAVIAEQAIAYLPNYDDMRNCTPKPT 376

  Fly   406 GTIDASHAAAIAAVEAATKAKASAIVVITTSGKSAFQVSKYRPRCPIIAVTRFAQTARQAHLYRG 470
            .|.:...|:|:|||   .:.||.||:|::|||.:...||||||.||||.|||..:.||.:|||||
Yeast   377 STTETVAASAVAAV---FEQKAKAIIVLSTSGTTPRLVSKYRPNCPIILVTRCPRAARFSHLYRG 438

  Fly   471 LVPLIYKEPGLGDWLKDVDVRVQFGLQVGKKNGFIKTGDSVVVVTGWKQGSGFTNTIRIVTV 532
            :.|.::::..:.||..||:.|:.||::..|:.|.:|.||:.|.:.|:|.|:|.:||:::.||
Yeast   439 VFPFVFEKEPVSDWTDDVEARINFGIEKAKEFGILKKGDTYVSIQGFKAGAGHSNTLQVSTV 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PyK	NP_524448.3	Pyruvate_Kinase	46..532	CDD:238178	246/490 (50%)
PyK	NP_524448.3	pyruv_kin	46..529	CDD:273424	246/487 (51%)
CDC19	NP_009362.1	Pyruvate_Kinase	18..500	CDD:238178	246/491 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343739
Domainoid	1	1.000	363	1.000	Domainoid score	I126
eggNOG	1	0.900	-	-		E1_COG0469
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37650
Inparanoid	1	1.050	471	1.000	Inparanoid score	I230
Isobase	1	0.950	-	0	Normalized mean entropy	S492
OMA	1	1.010	-	-		QHG53565
OrthoFinder	1	1.000	-	-		FOG0000841
OrthoInspector	1	1.000	-	-		mtm9214
orthoMCL	1	0.900	-	-		OOG6_100258
Panther	1	1.100	-	-	LDO	PTHR11817
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2173
SonicParanoid	1	1.000	-	-		X374
TreeFam	1	0.960	-	-
	16	15.740