DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PyK and AT5G63680

DIOPT Version :9

Sequence 1:	NP_524448.3	Gene:	PyK / 42620	FlyBaseID:	FBgn0267385	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001331216.1	Gene:	AT5G63680 / 836488	AraportID:	AT5G63680	Length:	510	Species:	Arabidopsis thaliana

Alignment Length:	515	Identity:	233/515 - (45%)
Similarity:	317/515 - (61%)	Gaps:	40/515 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 DSPVPHVRLSGIVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAVKNYSA 103
            |...|..:   ||||:||||.||.|:||::..|||:||.||||||||||..|:.|:|.|::|...
plant    16 DGRTPKTK---IVCTLGPASRSVTMIEKLLKAGMNVARFNFSHGSHEYHQETLDNLRTAMQNTGI 77

  Fly   104 KLGYEHPVAIALDTKGPEIRTGLIGGSGTAEIELKKGEKIKLTTNKEFLEKGSLEIVYVDYENIV 168
            .      .|:.|||||||||||.:....  .|:||:|::|.:||:.:.  ||..:.:.:.|:.:.
plant    78 L------AAVMLDTKGPEIRTGFLKDGN--PIQLKEGQEITITTDYDI--KGDEKTISMSYKKLP 132

  Fly   169 NVVKPGNRVFVDDGLISLIVREVGKDSLT--CEVENGGSLGSRKGVNLPGVPVDLPAVSEKDKSD 231
            ..|||||.:...||.|||.|.....::.|  |..||...||.||.||||||.||||.:::||..|
plant   133 VDVKPGNTILCADGSISLAVVSCDPNAGTVICRCENTAMLGERKNVNLPGVVVDLPTLTDKDVED 197

  Fly   232 LL-FGVEQEVDMIFASFIRNAAALTEIRKVLGEKGKNIKIISKIENQQGMHNLDEIIEAGDGIMV 295
            :| :||...:|||..||:|..:.|..:|||||...|:|.::||:|||:|:.|.|||:...|..||
plant   198 ILKWGVPNNIDMIALSFVRKGSDLVNVRKVLGSHSKSIMLMSKVENQEGVLNFDEILRETDAFMV 262

  Fly   296 ARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISDVANAVLDGAD 360
            ||||||:|||.||:|||||.||.:||.|||||:.||||||||:|.|||||||.:|||||||||.|
plant   263 ARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTD 327

  Fly   361 CVMLSGETAKGEYPLECVLTMAKTCKEAEAALWHQNLFNDLVRGA----GTIDASHAAAIAAVEA 421
            |||||||:|.|.||...|.||||.|.|||::|.:..:|.:::|..    .|::   :.|.:||..
plant   328 CVMLSGESAAGAYPEIAVKTMAKICIEAESSLDYNTIFKEMIRATPLPMSTLE---SLASSAVRT 389

  Fly   422 ATKAKASAIVVITTSGKSAFQVSKYRPRCPIIAVTRFAQT-------------ARQAHLYRGLVP 473
            |.||||..|:|:|..|.:|..|:||||..||::|.....|             ||.:.:||||:|
plant   390 ANKAKAKLIIVLTRGGTTAKLVAKYRPAVPILSVVVPVFTSDTFNWSCSDESPARHSLIYRGLIP 454

  Fly   474 LIYKEPGLGDWLKDVDVRVQFGLQVGKKNGFIKTGDSVVVVTGWKQGSGFTNTIRIVTVE 533
            ::.:........:..:..::..|:...:.|....||:||.:    ...|..:.|:|..|:
plant   455 VLGEGSAKATDSESTEEIIESALKSATEKGLCNHGDAVVAL----HRIGAASVIKICVVK 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PyK	NP_524448.3	Pyruvate_Kinase	46..532	CDD:238178	230/505 (46%)
PyK	NP_524448.3	pyruv_kin	46..529	CDD:273424	229/502 (46%)
AT5G63680	NP_001331216.1	PLN02461	1..510	CDD:215255	232/513 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	354	1.000	Domainoid score	I209
eggNOG	1	0.900	-	-		E1_COG0469
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37650
Inparanoid	1	1.050	410	1.000	Inparanoid score	I455
OMA	1	1.010	-	-		QHG53565
OrthoDB	1	1.010	-	-		D933620at2759
OrthoFinder	1	1.000	-	-		FOG0000841
OrthoInspector	1	1.000	-	-		mtm1077
orthoMCL	1	0.900	-	-		OOG6_100258
Panther	1	1.100	-	-	O	PTHR11817
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X374
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840