DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PyK and AT5G08570

DIOPT Version :9

Sequence 1:	NP_524448.3	Gene:	PyK / 42620	FlyBaseID:	FBgn0267385	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001318514.1	Gene:	AT5G08570 / 830758	AraportID:	AT5G08570	Length:	510	Species:	Arabidopsis thaliana

Alignment Length:	512	Identity:	229/512 - (44%)
Similarity:	314/512 - (61%)	Gaps:	34/512 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 DSPVPHVRLSGIVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAVKNYSA 103
            |..:|..:   ||||:||||.:|.|:||::..|||:||.||||||||||..|:.|:|.|:.|...
plant    16 DGRIPKTK---IVCTLGPASRTVSMIEKLLKAGMNVARFNFSHGSHEYHQETLDNLRSAMHNTGI 77

  Fly   104 KLGYEHPVAIALDTKGPEIRTGLIGGSGTAEIELKKGEKIKLTTNKEFLEKGSLEIVYVDYENIV 168
            .      .|:.|||||||||||.:....  .|:||:|::|.:||:.:.  :|....:.:.|:.:.
plant    78 L------AAVMLDTKGPEIRTGFLKDGN--PIQLKEGQEITITTDYDI--QGDESTISMSYKKLP 132

  Fly   169 NVVKPGNRVFVDDGLISLIVREVGKDSLT--CEVENGGSLGSRKGVNLPGVPVDLPAVSEKDKSD 231
            ..|||||.:...||.|||.|.....:|.|  |..||...||.||.||||||.||||.:::||..|
plant   133 LDVKPGNTILCADGSISLAVLSCDPESGTVRCRCENSAMLGERKNVNLPGVVVDLPTLTDKDIED 197

  Fly   232 LL-FGVEQEVDMIFASFIRNAAALTEIRKVLGEKGKNIKIISKIENQQGMHNLDEIIEAGDGIMV 295
            :| :||...:|||..||:|..:.|..:|||||...|:|.::||:|||:|:.|.|||:...|..||
plant   198 ILGWGVPNSIDMIALSFVRKGSDLVNVRKVLGSHAKSIMLMSKVENQEGVINFDEILRETDAFMV 262

  Fly   296 ARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISDVANAVLDGAD 360
            ||||||:|||.||:|||||.||.:||.|||||:.||||||||:|.|||||||.:|||||||||.|
plant   263 ARGDLGMEIPIEKIFLAQKLMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTD 327

  Fly   361 CVMLSGETAKGEYPLECVLTMAKTCKEAEAALWHQNLFNDLVRGAG-TIDASHAAAIAAVEAATK 424
            |||||||:|.|.||...|..|||.|.|||::|.:..:|.:::|... .:....:.|.:||..|.|
plant   328 CVMLSGESAAGAYPEIAVKVMAKICIEAESSLDYNTIFKEMIRATPLPMSPLESLASSAVRTANK 392

  Fly   425 AKASAIVVITTSGKSAFQVSKYRPRCPIIAVTRFAQT-------------ARQAHLYRGLVPLIY 476
            |:|..|:|:|..|.:|..|:||||..||::|.....|             ||.:.:||||:|::.
plant   393 ARAKLIIVLTRGGSTANLVAKYRPAVPILSVVVPVMTTDSFDWSCSDESPARHSLIYRGLIPMLA 457

  Fly   477 KEPGLGDWLKDVDVRVQFGLQVGKKNGFIKTGDSVVVVTGWKQGSGFTNTIRIVTVE 533
            :........:..:|.::..|:...:.|....||::|.:    ...|..:.|:|..|:
plant   458 EGSAKATDSEATEVIIEAALKSATQRGLCNRGDAIVAL----HRIGAASVIKICVVK 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PyK	NP_524448.3	Pyruvate_Kinase	46..532	CDD:238178	226/502 (45%)
PyK	NP_524448.3	pyruv_kin	46..529	CDD:273424	225/499 (45%)
AT5G08570	NP_001318514.1	PLN02461	1..510	CDD:215255	228/510 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	354	1.000	Domainoid score	I209
eggNOG	1	0.900	-	-		E1_COG0469
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37650
Inparanoid	1	1.050	410	1.000	Inparanoid score	I455
OMA	1	1.010	-	-		QHG53565
OrthoDB	1	1.010	-	-		D933620at2759
OrthoFinder	1	1.000	-	-		FOG0000841
OrthoInspector	1	1.000	-	-		mtm1077
orthoMCL	1	0.900	-	-		OOG6_100258
Panther	1	1.100	-	-	O	PTHR11817
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X374
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840