DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PyK and AT3G25960

DIOPT Version :9

Sequence 1:	NP_524448.3	Gene:	PyK / 42620	FlyBaseID:	FBgn0267385	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_189225.1	Gene:	AT3G25960 / 822193	AraportID:	AT3G25960	Length:	497	Species:	Arabidopsis thaliana

Alignment Length:	502	Identity:	224/502 - (44%)
Similarity:	310/502 - (61%)	Gaps:	42/502 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 IVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAVKNYSAKLGYEHPVAIA 114
            ||||:||||.||||:||::..|||:||.|||||||.||..|:.|:|.|:.|....      .|:.
plant    20 IVCTLGPASRSVEMIEKLLKAGMNVARFNFSHGSHSYHQETLDNLRTAMDNTGIL------CAVM 78

  Fly   115 LDTKGPEIRTGLIGGSGTAEIELKKGEKIKLTTNKEFLEKGSLEIVYVDYENIVNVVKPGNRVFV 179
            ||||.|.||||.:  .....|:||:|::|  |.:.::..:|....:.:.|:.:...:|||:.:..
plant    79 LDTKSPVIRTGFL--KEGKPIQLKQGQEI--TISIDYKIQGDSNTISMSYKKLAEDLKPGDVILC 139

  Fly   180 DDGLISLIVREVGK--DSLTCEVENGGSLGSRKGVNLPGVPVDLPAVSEKDKSDLL-FGVEQEVD 241
            .||.|||.|....|  ..:.|..||...||.||.|||||:.||||.::||||.|:: :||..::|
plant   140 SDGTISLNVLSCDKYLGLVRCRCENSALLGERKNVNLPGIVVDLPTLTEKDKEDIMQWGVPNKID 204

  Fly   242 MIFASFIRNAAALTEIRKVLGEKGKNIKIISKIENQQGMHNLDEIIEAGDGIMVARGDLGIEIPA 306
            :|..||:|..:.|.::||:|||..|:|.::||:|||:|:.|.|:|:|..|..||||||||:|||.
plant   205 IIALSFVRKGSDLIQVRKLLGEHSKSIMLMSKVENQEGVMNFDKILENSDAFMVARGDLGMEIPI 269

  Fly   307 EKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISDVANAVLDGADCVMLSGETAKG 371
            ||:|||||.||.:.|..||||:.||||||||...|||||||.:|||||||||.||||||||||.|
plant   270 EKMFLAQKTMINKANAHGKPVVTATQMLESMTVSPRPTRAEATDVANAVLDGTDCVMLSGETAAG 334

  Fly   372 EYPLECVLTMAKTCKEAEAALWHQNLFNDLVRGAGTIDAS--HAAAIAAVEAATKAKASAIVVIT 434
            .:|...||||::.|||||..: ..::.:....|..::..|  .:.|.:||..|....||||||:|
plant   335 AHPETAVLTMSRICKEAEDFI-DYDILHKKTLGMVSLPLSPIESLAASAVSTARSVFASAIVVLT 398

  Fly   435 TSGKSAFQVSKYRPRCPIIAV---------TRFAQTARQAHLYRGLVPLIYKEPGLGDWLKD-VD 489
            ..|.:|..|:||||..||::|         ...|..||:..:|||::|::      |...:| .:
plant   399 RGGYTAELVAKYRPSVPILSVIMPEIAECSDSVAHVARRGLIYRGIIPVV------GCSARDSTE 457

  Fly   490 VRVQFGLQVGKKNGFIKTGDSVVV---VTGWKQGSGFTNTIRIVTVE 533
            ..::..:...|..|..|||||:|.   :.|       ::.:|||:||
plant   458 EMIRLAIGFAKTKGICKTGDSIVALHKIDG-------SSIVRIVSVE 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PyK	NP_524448.3	Pyruvate_Kinase	46..532	CDD:238178	222/499 (44%)
PyK	NP_524448.3	pyruv_kin	46..529	CDD:273424	219/496 (44%)
AT3G25960	NP_189225.1	PLN02461	1..497	CDD:215255	222/500 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	354	1.000	Domainoid score	I209
eggNOG	1	0.900	-	-		E1_COG0469
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	410	1.000	Inparanoid score	I455
OMA	1	1.010	-	-		QHG53565
OrthoDB	1	1.010	-	-		D933620at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm1077
orthoMCL	1	0.900	-	-		OOG6_100258
Panther	1	1.100	-	-	O	PTHR11817
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X374
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.840