DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PyK and AT3G04050

DIOPT Version :9

Sequence 1:	NP_524448.3	Gene:	PyK / 42620	FlyBaseID:	FBgn0267385	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_187055.1	Gene:	AT3G04050 / 819560	AraportID:	AT3G04050	Length:	510	Species:	Arabidopsis thaliana

Alignment Length:	510	Identity:	227/510 - (44%)
Similarity:	316/510 - (61%)	Gaps:	45/510 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 IVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVANVRQAVKNYSAKLGYEHPVAIA 114
            ||||:||||.||||:||::..|||:||.|||||||.||..|:.|:|.|::|...      |.|:.
plant    20 IVCTLGPASRSVEMVEKLLKAGMNVARFNFSHGSHSYHQETLDNLRTAMENTCI------PCAVM 78

  Fly   115 LDTKGPEIRTGLIGGSGTAEIELKKGEKIKLTTNKEFLEKGSLEIVYVDYENIVNVVKPGNRVFV 179
            |||||||||||.:  .....:||.:|::|.::|  ::..:|....:.:.|:.:...:|.|:.:..
plant    79 LDTKGPEIRTGFL--KEGKPVELIQGQEITIST--DYTMEGDSNTISMSYKKLAEDLKSGDVILC 139

  Fly   180 DDGLISLIVREVGKD--SLTCEVENGGSLGSRKGVNLPGVPVDLPAVSEKDKSDLL-FGVEQEVD 241
            .||.|||.|....|:  .:....||...||.||.|||||:.||||.::|||:.|:| :||..::|
plant   140 SDGTISLTVLSCDKNLGLVRARCENSAVLGERKNVNLPGIVVDLPTLTEKDQEDILQWGVPNKID 204

  Fly   242 MIFASFIRNAAALTEIRKVLGEKGKNIKIISKIENQQGMHNLDEIIEAGDGIMVARGDLGIEIPA 306
            :|..||:|..:.|.|:||:|||..|:|.::||:|||:|:.|.|:|:|..|..||||||||:|||.
plant   205 IIALSFVRKGSDLVEVRKLLGENAKSIMLMSKVENQEGVMNFDKILEYSDAFMVARGDLGMEIPI 269

  Fly   307 EKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISDVANAVLDGADCVMLSGETAKG 371
            ||:|||||.||.:.|..|||::.||||||||.|.|||||||.:|||||||||.||||||||||.|
plant   270 EKMFLAQKMMIQKANALGKPIVTATQMLESMTKSPRPTRAEATDVANAVLDGTDCVMLSGETAAG 334

  Fly   372 EYPLECVLTMAKTCKEAEAALWHQNL---FNDLVRGAGTIDASHAAAIAAVEAATKAKASAIVVI 433
            .:|...||||::.|||||..:.:..:   ..|:|  :..:....:.|.:||..|....|:||||:
plant   335 AHPETAVLTMSRICKEAEDFIDYDTMHKKIQDIV--SLPLSPIESLAASAVSTARSLCAAAIVVL 397

  Fly   434 TTSGKSAFQVSKYRPRCPIIAV-----TR-----------FAQTARQAHLYRGLVPLIYKEPGLG 482
            |..|.:...|:||||..||::|     ||           .|..||:..:|||:||::.......
plant   398 TKGGYTVELVAKYRPSVPILSVIVPEITRTDDFEWSCSESAAHVARRGLIYRGIVPVMATGASAR 462

  Fly   483 DWLKD-VDVRVQFGLQVGKKNGFIKTGDSVVV---VTGWKQGSGFTNTIRIVTVE 533
            ...|| .:..:||.::..||.|..|||||:|.   :.|       ::.::|:.||
plant   463 SSNKDSTEETIQFAIEFAKKKGICKTGDSIVALHKIDG-------SSVVKILNVE 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PyK	NP_524448.3	Pyruvate_Kinase	46..532	CDD:238178	225/507 (44%)
PyK	NP_524448.3	pyruv_kin	46..529	CDD:273424	224/504 (44%)
AT3G04050	NP_187055.1	PLN02461	1..510	CDD:215255	225/508 (44%)
AT3G04050	NP_187055.1	Pyruvate_Kinase	17..496	CDD:304951	223/487 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	354	1.000	Domainoid score	I209
eggNOG	1	0.900	-	-		E1_COG0469
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	410	1.000	Inparanoid score	I455
OMA	1	1.010	-	-		QHG53565
OrthoDB	1	1.010	-	-		D933620at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm1077
orthoMCL	1	0.900	-	-		OOG6_100258
Panther	1	1.100	-	-	O	PTHR11817
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X374
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.840