Protein Alignment PyK and PKM

DIOPT Version :10

• Sequence 1: NP_524448.3
• Gene: PyK / 42620
• FlyBaseID: FBgn0267385
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: XP_047288618.1
• Gene: PKM / 5315
• HGNCID: 9021
• Length: 609
• Species: Homo sapiens
• Alignment Length: 532
• Identity: 341/532 - (64%)
• Similarity: 414/532 - (77%)
• Gaps: 9/532 - (1%)

  Fly    10 APQLKPN--------EVPQNMAAGADTQLEHMCRLQFDSPVPHVRLSGIVCTIGPASSSVEMLEK 66
            |...||:        :..|..||.|||.|||||||..|||....|.:||:|||||||.|||.|::
Human    77 AAMSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKE 141

  Fly    67 MMATGMNIARMNFSHGSHEYHAATVANVRQAVKNYSAKLGYEHPVAIALDTKGPEIRTGLIGGSG 131
            |:.:|||:||:|||||:|||||.|:.|||.|.:::::......|||:||||||||||||||.|||
Human   142 MIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSG 206

  Fly   132 TAEIELKKGEKIKLTTNKEFLEKGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDSL 196
            |||:|||||..:|:|.:..::||....|:::||:||..||:.|::::||||||||.|::.|.|.|
Human   207 TAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFL 271

  Fly   197 TCEVENGGSLGSRKGVNLPGVPVDLPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVL 261
            ..||||||||||:|||||||..||||||||||..||.|||||:|||:||||||.|:.:.|:||||
Human   272 VTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVL 336

  Fly   262 GEKGKNIKIISKIENQQGMHNLDEIIEAGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKP 326
            |||||||||||||||.:|:...|||:||.||||||||||||||||||||||||.||.|||:||||
Human   337 GEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKP 401

  Fly   327 VICATQMLESMVKKPRPTRAEISDVANAVLDGADCVMLSGETAKGEYPLECVLTMAKTCKEAEAA 391
            |||||||||||:|||||||||.|||||||||||||:|||||||||:||||.|.......:|||||
Human   402 VICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAA 466

  Fly   392 LWHQNLFNDLVRGAG-TIDASHAAAIAAVEAATKAKASAIVVITTSGKSAFQVSKYRPRCPIIAV 455
            ::|..||.:|.|.|. |.|.:.|.|:.||||:.|..:.||:|:|.||:||.||::||||.|||||
Human   467 IYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAV 531

  Fly   456 TRFAQTARQAHLYRGLVPLIYKEPGLGDWLKDVDVRVQFGLQVGKKNGFIKTGDSVVVVTGWKQG 520
            ||..|||||||||||:.|::.|:|....|.:|||:||.|.:.|||..||.|.||.|:|:|||:.|
Human   532 TRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPG 596

  Fly   521 SGFTNTIRIVTV 532
            ||||||:|:|.|
Human   597 SGFTNTMRVVPV 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PyK	NP_524448.3	Pyruvate_Kinase	46..532	CDD:238178	321/486 (66%)
PKM	XP_047288618.1	Pyruvate_Kinase	120..608	CDD:238178	321/487 (66%)