DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PyK and CG7069

DIOPT Version :9

Sequence 1:	NP_524448.3	Gene:	PyK / 42620	FlyBaseID:	FBgn0267385	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_651030.1	Gene:	CG7069 / 42621	FlyBaseID:	FBgn0038952	Length:	744	Species:	Drosophila melanogaster

Alignment Length:	468	Identity:	264/468 - (56%)
Similarity:	330/468 - (70%)	Gaps:	14/468 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 MNIARMNFSHGSHEYHAATVANVRQAVKNYSAKLGYEHPVAIALDTKGPEIRTG-LIGGSGTAEI 135
            |.:.||||||||||||..|:...|:|:..|..:.|....:|||||||||||||| |.||:..|||
  Fly     1 MRVVRMNFSHGSHEYHCQTIQAARKAIAMYVEQTGLPRTLAIALDTKGPEIRTGKLAGGNDRAEI 65

  Fly   136 ELKKGEKIKLTTNKEFLEKGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDSLTCEV 200
            |||.|:|:.|:|.||..:|.:.:.:||||:.:..:||||||||||||||:|||:|...|.:.|:|
  Fly    66 ELKTGDKVTLSTKKEMADKSNKDNIYVDYQRLPQLVKPGNRVFVDDGLIALIVKESKGDEVICQV 130

  Fly   201 ENGGSLGSRKGVNLPGVPVDLPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEKG 265
            ||||.|||.||:||||||||||:|:||||.||.||.||:||||||||||:|.||.|||:|||..|
  Fly   131 ENGGKLGSHKGINLPGVPVDLPSVTEKDKQDLKFGAEQKVDMIFASFIRDANALKEIRQVLGPAG 195

  Fly   266 KNIKIISKIENQQGMHNLDEIIEAGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICA 330
            ..|||||||||.||:.|:|:||...|||||||||:|||||.|.|.||||:::|:|||.|||||||
  Fly   196 ACIKIISKIENHQGLVNIDDIIRESDGIMVARGDMGIEIPTEDVPLAQKSIVAKCNKVGKPVICA 260

  Fly   331 TQMLESMVKKPRPTRAEISDVANAVLDGADCVMLSGETAKGEYPLECVLTMAKTCKEAEAALWHQ 395
            |||:|||..||||||||.||||||:.||.|.||||||||||:||:|||..||:.|.:.||.||::
  Fly   261 TQMMESMTNKPRPTRAEASDVANAIFDGCDAVMLSGETAKGKYPVECVQCMARICAKVEAVLWYE 325

  Fly   396 NLFNDLVRGAGTIDASHAAAI--AAVEAATKAKASAIVVITTSGKSAFQVSKYRPRCPIIAVTRF 458
            :|.|.|.|...|..|.|.:|:  |..||||..:|.||||.:.....|..||..||.|||:.:|..
  Fly   326 SLQNSLKREIRTSAADHISAVTTAIAEAATVGQARAIVVASPCSMVAQMVSHMRPPCPIVMLTGN 390

  Fly   459 AQTARQAHLYRGLVPLIYKEPGLGDWLKDVDVR--VQFGLQVGKKNGFIKTGD--SVVVVTGWKQ 519
            ...|.|:.|:||:.||:.:|..:|.:    :.|  :|.||::..|...::.|.  |||:|...
  Fly   391 ESEAAQSLLFRGIYPLLVEEMVIGSF----NFRRIMQSGLKLMGKMDILEPGQKGSVVLVNAM-- 449

  Fly   520 GSGFTNTIRIVTV 532
             |....|.|:.|:
  Fly   450 -SAEKITFRLFTI 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PyK	NP_524448.3	Pyruvate_Kinase	46..532	CDD:238178	263/466 (56%)
PyK	NP_524448.3	pyruv_kin	46..529	CDD:273424	262/463 (57%)
CG7069	NP_651030.1	PRK05826	1..446	CDD:235619	259/448 (58%)
CG7069	NP_651030.1	Pyruvate_Kinase	1..410	CDD:304951	248/408 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448740
Domainoid	1	1.000	354	1.000	Domainoid score	I209
eggNOG	1	0.900	-	-		E1_COG0469
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	410	1.000	Inparanoid score	I455
Isobase	1	0.950	-	0	Normalized mean entropy	S492
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D219692at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm51388
orthoMCL	1	0.900	-	-		OOG6_100258
Panther	1	1.100	-	-	P	PTHR11817
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X374
	11	10.750