DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PyK and CG7362

DIOPT Version :9

Sequence 1:	NP_524448.3	Gene:	PyK / 42620	FlyBaseID:	FBgn0267385	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_650388.2	Gene:	CG7362 / 41787	FlyBaseID:	FBgn0038258	Length:	793	Species:	Drosophila melanogaster

Alignment Length:	514	Identity:	199/514 - (38%)
Similarity:	276/514 - (53%)	Gaps:	109/514 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 TQLEHMCRLQFDSPVPHVRLSGIVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYHAATVA 92
            :||::..||||.:|...:.|:.|:|||||:||..|:|..::..||.:.|::||.|:|:.|...:.
  Fly    15 SQLDYQSRLQFQAPALRLPLTSIICTIGPSSSQPEVLLNLIHAGMKVVRLDFSDGTHDCHCQAIQ 79

  Fly    93 NVRQAVKNYSAKLGYEHPVAIALDTKGPEIRTGLIGGSGTAEIELKKGEKIKLTTNKEFLEKGSL 157
            ..|:|:..|:.:.|....:|||||||||.|
  Fly    80 AARKAIAMYAEETGLPRSLAIALDTKGPVI----------------------------------- 109

  Fly   158 EIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDSLTCEVENGGSLGSRKGVNLPGVPVDLP 222
                                                                   |..||..||.
  Fly   110 -------------------------------------------------------NPQGVAADLN 119

  Fly   223 AVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVLG--EKGKNIKIISKIENQQGMHNLDE 285
            |::|:||.||.||.:|:||||||||||:|.||.|||:.||  ...::||||||||:||.:.|:||
  Fly   120 AITEQDKLDLKFGADQKVDMIFASFIRDAKALKEIRQALGACPSSEHIKIISKIESQQALANIDE 184

  Fly   286 IIEAGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRAEISD 350
            ||...||||||.|::|.||..|.|.||||:::|:|||.|||||||.||:.||:.||||||||.||
  Fly   185 IIRESDGIMVALGNMGNEIALEAVPLAQKSIVAKCNKVGKPVICANQMMNSMITKPRPTRAESSD 249

  Fly   351 VANAVLDGADCVMLSGETAKGEYPLECVLTMAKTCKEAEAALWHQNLFNDLVRGAGTIDASHAAA 415
            ||||:|||.|.::||.|||||:||::||..||:.|.:.|:.||::::.|:|........|.|.:|
  Fly   250 VANAILDGCDALVLSDETAKGKYPVQCVQCMARICAKVESVLWYESIQNNLKSEVRINAADHISA 314

  Fly   416 I--AAVEAATKAKASAIVVITTSGKSAFQVSKYRPRCPIIAVTRFAQTARQAHLYRGLVPLIYKE 478
            :  |..||||.::|.||||.:.....:..||:.||.|||:.:|.....|.|:.|:||:.||:.||
  Fly   315 VSTAIAEAATVSQAQAIVVASPCSIVSQMVSQMRPPCPIVLLTGCPHEAAQSLLFRGVYPLLVKE 379

  Fly   479 PGLGDWLKDVDVR----VQFGLQVGKKNGFIKTGD--SVVVVTGWKQGSGFTNTIRIVT 531
            ...|      .|.    :|.||::..|...:|.|.  ::|:|...   |....|.|:.|
  Fly   380 MVYG------SVNYCRIMQSGLKILAKLDILKAGQRGTLVLVNAM---SADKLTFRLFT 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PyK	NP_524448.3	Pyruvate_Kinase	46..532	CDD:238178	192/496 (39%)
PyK	NP_524448.3	pyruv_kin	46..529	CDD:273424	190/492 (39%)
CG7362	NP_650388.2	Pyruvate_Kinase	35..407	CDD:304951	184/467 (39%)
CG7362	NP_650388.2	pyruv_kin	35..391	CDD:273424	179/451 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45448741
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0469
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S492
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D219692at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100258
Panther	1	1.100	-	-	P	PTHR11817
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.700