DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PyK and pyk1

DIOPT Version :9

Sequence 1:	NP_524448.3	Gene:	PyK / 42620	FlyBaseID:	FBgn0267385	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_594346.1	Gene:	pyk1 / 2543557	PomBaseID:	SPAC4H3.10c	Length:	509	Species:	Schizosaccharomyces pombe

Alignment Length:	523	Identity:	269/523 - (51%)
Similarity:	359/523 - (68%)	Gaps:	29/523 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 PQNMAAGADTQLEHMCRLQFDSPVPHV-RLSGIVCTIGPASSSVEMLEKMMATGMNIARMNFSHG 82
            |:...||.:::|:          :|.| |.:.|:|||||.|::||.|.|:...||||.|||||||
pombe     8 PKQWVAGLNSELD----------IPAVNRRTSIICTIGPKSNNVETLCKLRDAGMNIVRMNFSHG 62

  Fly    83 SHEYHAATVANVRQAVKNYSAKLGYEHPVAIALDTKGPEIRTGL-IGGSGTAEIELKKGEKIKLT 146
            |:|||.:.:.|.|:|     :......|:||||||||||||||| :||:   :..:..|.::..|
pombe    63 SYEYHQSVIDNARKA-----SATNPLFPLAIALDTKGPEIRTGLTVGGT---DYPISSGHEMIFT 119

  Fly   147 TNKEFLEKGSLEIVYVDYENIVNVVKPGNRVFVDDGLISL-IVREVGKDSLTCEVENGGSLGSRK 210
            |:..:.||.:.:::|:||:||..|::||..::||||::|. ::.:|...:|...|.|.|.:.|:|
pombe   120 TDDAYAEKCNDKVMYIDYKNITKVIQPGRIIYVDDGILSFTVIEKVDDKNLKVRVNNNGKISSKK 184

  Fly   211 GVNLPGVPVDLPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEKGKNIKIISKIE 275
            |||||...|||||:|||||:||.|||:..||||||||||.|..:..||:||||:|||||||.|||
pombe   185 GVNLPKTDVDLPALSEKDKADLRFGVKNGVDMIFASFIRRAEDVIHIREVLGEEGKNIKIICKIE 249

  Fly   276 NQQGMHNLDEIIEAGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKK 340
            ||||::|.|.|::..||||||||||||||||.:||:|||.|||:||.|||||.|||||||||...
pombe   250 NQQGVNNFDSILDVTDGIMVARGDLGIEIPASQVFVAQKMMIAKCNIAGKPVACATQMLESMTYN 314

  Fly   341 PRPTRAEISDVANAVLDGADCVMLSGETAKGEYPLECVLTMAKTCKEAEAALWHQNLFNDLVRGA 405
            |||||||:|||.||||||||.|||||||.||.||:|.|..||:|.:.|||::.:.:|:.::.
pombe   315 PRPTRAEVSDVGNAVLDGADLVMLSGETTKGSYPVEAVTYMAETARVAEASIPYGSLYQEMF--- 376

  Fly   406 GTID-----ASHAAAIAAVEAATKAKASAIVVITTSGKSAFQVSKYRPRCPIIAVTRFAQTARQA 465
            |.:.     |:...|:||:.|:.::.|.||||::|||.:|...|||||..||:.|||..|.|||:
pombe   377 GLVRRPLECATETTAVAAIGASIESDAKAIVVLSTSGNTARLCSKYRPSIPIVMVTRCPQRARQS 441

  Fly   466 HLYRGLVPLIYKEPGLGDWLKDVDVRVQFGLQVGKKNGFIKTGDSVVVVTGWKQGSGFTNTIRIV 530
            ||.||:.|:||::..|.||.||||.||.:|.|...|...:|.||.::|:.|...|.|.|:..|:.
pombe   442 HLNRGVYPVIYEKEPLSDWQKDVDARVAYGCQQAYKMNILKKGDKIIVLQGAVGGKGHTSIFRLT 506

  Fly   531 TVE 533
            ..|
pombe   507 VAE 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PyK	NP_524448.3	Pyruvate_Kinase	46..532	CDD:238178	262/492 (53%)
PyK	NP_524448.3	pyruv_kin	46..529	CDD:273424	261/489 (53%)
pyk1	NP_594346.1	Pyruvate_Kinase	25..508	CDD:238178	262/493 (53%)
pyk1	NP_594346.1	pyruv_kin	26..505	CDD:273424	261/489 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	393	1.000	Domainoid score	I117
eggNOG	1	0.900	-	-		E1_COG0469
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37650
Inparanoid	1	1.050	500	1.000	Inparanoid score	I243
OMA	1	1.010	-	-		QHG53565
OrthoFinder	1	1.000	-	-		FOG0000841
OrthoInspector	1	1.000	-	-		oto101014
orthoMCL	1	0.900	-	-		OOG6_100258
Panther	1	1.100	-	-	LDO	PTHR11817
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2173
SonicParanoid	1	1.000	-	-		X374
TreeFam	1	0.960	-	-
	14	13.860