DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PyK and Pklr

DIOPT Version :9

Sequence 1:	NP_524448.3	Gene:	PyK / 42620	FlyBaseID:	FBgn0267385	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	XP_006232655.1	Gene:	Pklr / 24651	RGDID:	3336	Length:	574	Species:	Rattus norvegicus

Alignment Length:	512	Identity:	300/512 - (58%)
Similarity:	388/512 - (75%)	Gaps:	3/512 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AAGADTQLEHMCRLQFDSPVPHVRLSGIVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYH 87
            ||.|||.|||:|.|..||.....|.:.|:.||||||.||:.|::|:..||||||:||||||||||
  Rat    63 AAMADTFLEHLCLLDIDSQPVAARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYH 127

  Fly    88 AATVANVRQAVKNY-SAKLGYEHPVAIALDTKGPEIRTGLIGGSGTAEIELKKGEKIKLTTNKEF 151
            |.::||:|:|.::: ::.|.| .||||||||||||||||::.|...:|:|:.||.::.:|.:.:|
  Rat   128 AESIANIREATESFATSPLSY-RPVAIALDTKGPEIRTGVLQGGPESEVEIVKGSQVLVTVDPKF 191

  Fly   152 LEKGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDSLTCEVENGGSLGSRKGVNLPG 216
            ..:|..:.|:|||.||..||..|.|:::|||||||:|:::|.:.|..|||:||.||||||||||.
  Rat   192 QTRGDAKTVWVDYHNITRVVAVGGRIYIDDGLISLVVQKIGPEGLVTEVEHGGILGSRKGVNLPN 256

  Fly   217 VPVDLPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEKGKNIKIISKIENQQGMH 281
            ..||||.:||:|..||.|||:..||:|||||:|.|:.:..:|..||.:|:||||||||||.:|:.
  Rat   257 TEVDLPGLSEQDLLDLRFGVQHNVDIIFASFVRKASDVLAVRDALGPEGQNIKIISKIENHEGVK 321

  Fly   282 NLDEIIEAGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRA 346
            ..|||:|..||||||||||||||||||||||||.||.|||.|||||:|||||||||:.|.|||||
  Rat   322 KFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRA 386

  Fly   347 EISDVANAVLDGADCVMLSGETAKGEYPLECVLTMAKTCKEAEAALWHQNLFNDLVRGAG-TIDA 410
            |.|||||||||||||:|||||||||.:|:|.|:......:|||||::|:.||.:|.|.|. :.|.
  Rat   387 ETSDVANAVLDGADCIMLSGETAKGSFPVEAVMMQHAIAREAEAAVYHRQLFEELRRAAPLSRDP 451

  Fly   411 SHAAAIAAVEAATKAKASAIVVITTSGKSAFQVSKYRPRCPIIAVTRFAQTARQAHLYRGLVPLI 475
            :...||.||||:.|..|:||:|:|.:|:||..:|:||||..:|||||.||.|||.||.||:.||:
  Rat   452 TEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSQYRPRAAVIAVTRSAQAARQVHLSRGVFPLL 516

  Fly   476 YKEPGLGDWLKDVDVRVQFGLQVGKKNGFIKTGDSVVVVTGWKQGSGFTNTIRIVTV 532
            |:||....|..|||.|||||::.||..||::.||.|:|||||:.|||:||.:|:::|
  Rat   517 YREPPEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSV 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PyK	NP_524448.3	Pyruvate_Kinase	46..532	CDD:238178	287/487 (59%)
PyK	NP_524448.3	pyruv_kin	46..529	CDD:273424	286/484 (59%)
Pklr	XP_006232655.1	Pyruvate_Kinase	85..573	CDD:238178	287/488 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340673
Domainoid	1	1.000	492	1.000	Domainoid score	I352
eggNOG	1	0.900	-	-		E1_COG0469
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	664	1.000	Inparanoid score	I722
OMA	1	1.010	-	-		QHG53565
OrthoDB	1	1.010	-	-		D219692at33208
OrthoFinder	1	1.000	-	-		FOG0000841
OrthoInspector	1	1.000	-	-		otm45163
orthoMCL	1	0.900	-	-		OOG6_100258
Panther	1	1.100	-	-	O	PTHR11817
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X374
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770