Protein Alignment PyK and Pklr

DIOPT Version :9

• Sequence 1: NP_524448.3
• Gene: PyK / 42620
• FlyBaseID: FBgn0267385
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: XP_006501198.1
• Gene: Pklr / 18770
• MGIID: 97604
• Length: 598
• Species: Mus musculus
• Alignment Length: 512
• Identity: 300/512 - (58%)
• Similarity: 386/512 - (75%)
• Gaps: 3/512 - (0%)

  Fly    23 AAGADTQLEHMCRLQFDSPVPHVRLSGIVCTIGPASSSVEMLEKMMATGMNIARMNFSHGSHEYH 87
            ||.|||.|||:|.|..||.....|.:.|:.||||||.||:.|::|:..||||||:||||||||||
Mouse    87 AAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYH 151

  Fly    88 AATVANVRQAVKNY-SAKLGYEHPVAIALDTKGPEIRTGLIGGSGTAEIELKKGEKIKLTTNKEF 151
            |.::||:|:|.::: ::.|.| .||||||||||||||||::.|...:|:|:.||.::.:|.:.:|
Mouse   152 AESIANIREAAESFATSPLSY-RPVAIALDTKGPEIRTGVLQGGPESEVEIVKGSQVLVTVDPKF 215

  Fly   152 LEKGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDSLTCEVENGGSLGSRKGVNLPG 216
            ..:|..:.|:|||.||..||..|.|:::|||||||:||::|.:.|..|||:||.||:|||||||.
Mouse   216 RTRGDAKTVWVDYHNITQVVAVGGRIYIDDGLISLVVRKIGPEGLVTEVEHGGFLGNRKGVNLPN 280

  Fly   217 VPVDLPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEKGKNIKIISKIENQQGMH 281
            ..||||.:||:|..||.||||..||:|||||:|.|:.:..:|..||.:|:.|||||||||.:|:.
Mouse   281 AEVDLPGLSEQDLLDLRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRGIKIISKIENHEGVK 345

  Fly   282 NLDEIIEAGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKPRPTRA 346
            ..|||:|..||||||||||||||||||||||||.||.|||.|||||:|||||||||:.|.|||||
Mouse   346 KFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRA 410

  Fly   347 EISDVANAVLDGADCVMLSGETAKGEYPLECVLTMAKTCKEAEAALWHQNLFNDLVRGAG-TIDA 410
            |.|||||||||||||:|||||||||.:|:|.|.......:|||||::|:.||.:|.|.|. :.|.
Mouse   411 ETSDVANAVLDGADCIMLSGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDP 475

  Fly   411 SHAAAIAAVEAATKAKASAIVVITTSGKSAFQVSKYRPRCPIIAVTRFAQTARQAHLYRGLVPLI 475
            :...||.||||:.|..|:||:|:|.:|:||..:|:||||..:|||||.||.|||.||.||:.||:
Mouse   476 TEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLSRGVFPLL 540

  Fly   476 YKEPGLGDWLKDVDVRVQFGLQVGKKNGFIKTGDSVVVVTGWKQGSGFTNTIRIVTV 532
            |:||....|..|||.|||||::.||..||::.||.|:|||||:.|||:||.:|::|:
Mouse   541 YREPPEAVWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLTI 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PyK	NP_524448.3	Pyruvate_Kinase	46..532	CDD:238178	287/487 (59%)
		pyruv_kin	46..529	CDD:273424	286/484 (59%)
Pklr	XP_006501198.1	Pyruvate_Kinase	109..597	CDD:238178	287/488 (59%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836950
Domainoid	1	1.000	495	1.000	Domainoid score	I362
eggNOG	1	0.900	-	-		E1_COG0469
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	669	1.000	Inparanoid score	I742
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53565
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000841
OrthoInspector	1	1.000	-	-		otm43097
orthoMCL	1	0.900	-	-		OOG6_100258
Panther	1	1.100	-	-	O	PTHR11817
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2173
SonicParanoid	1	1.000	-	-		X374
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.790