DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PyK and pklr

DIOPT Version :9

Sequence 1:	NP_524448.3	Gene:	PyK / 42620	FlyBaseID:	FBgn0267385	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_958446.1	Gene:	pklr / 114551	ZFINID:	ZDB-GENE-010907-1	Length:	538	Species:	Danio rerio

Alignment Length:	530	Identity:	296/530 - (55%)
Similarity:	384/530 - (72%)	Gaps:	4/530 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 YDEAPQLKPNEVPQNM--AAGADTQLEHMCRLQFDSPVPHVRLSGIVCTIGPASSSVEMLEKMMA 69
            |.|...|..:.:.:..  |:.|||.|||:|.|..|......|.:.|:|||||||.|:..|::|:.
Zfish     8 YSEVMALPDSFIQKQQLDASMADTFLEHLCLLDIDQEPITARNTSIICTIGPASRSITKLQEMVK 72

  Fly    70 TGMNIARMNFSHGSHEYHAATVANVRQAVKNYSAKLGYEHPVAIALDTKGPEIRTGLIGGSGTAE 134
            .||||||:|||||:|:|||.|:.|||:||:..::...|..|||||||||||||||||:.|...||
Zfish    73 AGMNIARLNFSHGTHQYHAETIRNVREAVETLTSDPLYYRPVAIALDTKGPEIRTGLVKGRADAE 137

  Fly   135 IELKKGEKIKLTTNKEFLEKGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDSLTCE 199
            :.|::|..:::.|.:...|:....::::||.::..|:|..:|:::||||::|.|.|:|...|...
Zfish   138 VTLERGALVRVVTAECEREQTDGSVIWMDYPSLTRVLKKDSRIYIDDGLLALRVLEIGDSWLQAR 202

  Fly   200 VENGGSLGSRKGVNLPGVP-VDLPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGE 263
            |||||.|||.|||||||.. :|||||||:|:|||.|||||:||||||||||.|..:..:|..||.
Zfish   203 VENGGVLGSSKGVNLPGAELLDLPAVSERDRSDLQFGVEQQVDMIFASFIRCAEDVRAVRDALGP 267

  Fly   264 KGKNIKIISKIENQQGMHNLDEIIEAGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVI 328
            :|.:||||||:|::||:.|.:::::..||:|||||||||||||||||:|||.||.|||.||||||
Zfish   268 QGHDIKIISKVESRQGVRNFEQVLQESDGVMVARGDLGIEIPAEKVFIAQKMMIGRCNSAGKPVI 332

  Fly   329 CATQMLESMVKKPRPTRAEISDVANAVLDGADCVMLSGETAKGEYPLECVLTMAKTCKEAEAALW 393
            ||||||||||...||||||.|||||||||||||||||||||||.:|:|.|..|...|:|||||::
Zfish   333 CATQMLESMVHHARPTRAESSDVANAVLDGADCVMLSGETAKGHFPVEAVAMMHSICREAEAAIF 397

  Fly   394 HQNLFNDLVRGAG-TIDASHAAAIAAVEAATKAKASAIVVITTSGKSAFQVSKYRPRCPIIAVTR 457
            ||.||.:|.|... :.|.:...||.|||::.|..|.||:::||||:||..:|:||||||||||||
Zfish   398 HQQLFEELRRLTPLSSDPTEVTAIGAVESSYKCCAGAIIILTTSGRSAQLLSRYRPRCPIIAVTR 462

  Fly   458 FAQTARQAHLYRGLVPLIYKEPGLGDWLKDVDVRVQFGLQVGKKNGFIKTGDSVVVVTGWKQGSG 522
            .||.|||:.|.||:.|.:::.|....|..|||.||.|.:.:||..||.::||.|:|||||..|||
Zfish   463 NAQVARQSQLLRGVFPALFRAPPAEVWADDVDNRVTFAMDIGKARGFFRSGDMVIVVTGWSPGSG 527

  Fly   523 FTNTIRIVTV 532
            .||.:|.|||
Zfish   528 HTNIMRAVTV 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PyK	NP_524448.3	Pyruvate_Kinase	46..532	CDD:238178	281/487 (58%)
PyK	NP_524448.3	pyruv_kin	46..529	CDD:273424	279/484 (58%)
pklr	NP_958446.1	Pyruvate_Kinase	48..537	CDD:238178	281/488 (58%)
pklr	NP_958446.1	pyruv_kin	49..533	CDD:273424	279/483 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580480
Domainoid	1	1.000	147	1.000	Domainoid score	I4454
eggNOG	1	0.900	-	-		E1_COG0469
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	657	1.000	Inparanoid score	I752
OMA	1	1.010	-	-		QHG53565
OrthoDB	1	1.010	-	-		D219692at33208
OrthoFinder	1	1.000	-	-		FOG0000841
OrthoInspector	1	1.000	-	-		otm25874
orthoMCL	1	0.900	-	-		OOG6_100258
Panther	1	1.100	-	-	O	PTHR11817
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X374
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770