DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PyK and LOC100364062

DIOPT Version :9

Sequence 1:	NP_524448.3	Gene:	PyK / 42620	FlyBaseID:	FBgn0267385	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	XP_003752000.1	Gene:	LOC100364062 / 100364062	RGDID:	2321795	Length:	532	Species:	Rattus norvegicus

Alignment Length:	517	Identity:	337/517 - (65%)
Similarity:	407/517 - (78%)	Gaps:	1/517 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 EVPQNMAAGADTQLEHMCRLQFDSPVPHVRLSGIVCTIGPASSSVEMLEKMMATGMNIARMNFSH 81
            :..|..||.|||.|||||||..||.....|.:||:|||||||.|||||::|:.:|||:||:||||
  Rat    14 QTQQLHAAMADTFLEHMCRLDIDSAPITARNTGIICTIGPASRSVEMLKEMIKSGMNVARLNFSH 78

  Fly    82 GSHEYHAATVANVRQAVKNYSAKLGYEHPVAIALDTKGPEIRTGLIGGSGTAEIELKKGEKIKLT 146
            |:|||||.|:.|||.|.:::::......|||:||||||||||||||.||||||:|||||..:|:|
  Rat    79 GTHEYHAETIKNVRAATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKIT 143

  Fly   147 TNKEFLEKGSLEIVYVDYENIVNVVKPGNRVFVDDGLISLIVREVGKDSLTCEVENGGSLGSRKG 211
            .:..::||....|:::||:||..||:.|::::||||||||.|:|.|.|.|..||||||||||:||
  Rat   144 LDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKEKGADYLVTEVENGGSLGSKKG 208

  Fly   212 VNLPGVPVDLPAVSEKDKSDLLFGVEQEVDMIFASFIRNAAALTEIRKVLGEKGKNIKIISKIEN 276
            |||||..||||||||||..||.|||||:|||:||||||.||.:.|:|||||||||||||||||||
  Rat   209 VNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAADVHEVRKVLGEKGKNIKIISKIEN 273

  Fly   277 QQGMHNLDEIIEAGDGIMVARGDLGIEIPAEKVFLAQKAMIARCNKAGKPVICATQMLESMVKKP 341
            .:|:...|||:||.||||||||||||||||||||||||.||.|||:||||||||.||||||:|||
  Rat   274 HEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICANQMLESMIKKP 338

  Fly   342 RPTRAEISDVANAVLDGADCVMLSGETAKGEYPLECVLTMAKTCKEAEAALWHQNLFNDLVRGAG 406
            ||||||.|||||||||||||:||||.||||:||||.|.......:|||||::|..||.:|.|.|.
  Rat   339 RPTRAEGSDVANAVLDGADCIMLSGVTAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAP 403

  Fly   407 -TIDASHAAAIAAVEAATKAKASAIVVITTSGKSAFQVSKYRPRCPIIAVTRFAQTARQAHLYRG 470
             |.|.:.|||:.||||:.|..:.||:|:|.||:||.||::|.||.|||||||..|||||||||||
  Rat   404 ITSDPTEAAAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYLPRAPIIAVTRNPQTARQAHLYRG 468

  Fly   471 LVPLIYKEPGLGDWLKDVDVRVQFGLQVGKKNGFIKTGDSVVVVTGWKQGSGFTNTIRIVTV 532
            :.|::.|:..|..|.:|||:||...:.|||..||.|.||.|:|:|||:.|||||||:|:|.|
  Rat   469 IFPVLCKDAVLDAWAEDVDLRVNLAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPV 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PyK	NP_524448.3	Pyruvate_Kinase	46..532	CDD:238178	321/486 (66%)
PyK	NP_524448.3	pyruv_kin	46..529	CDD:273424	319/483 (66%)
LOC100364062	XP_003752000.1	Pyruvate_Kinase	42..530	CDD:238178	321/487 (66%)
LOC100364062	XP_003752000.1	pyruv_kin	43..527	CDD:273424	319/483 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D219692at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010